Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O75083

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-606	P		NT	<%Agarwal et al., 2012[]%>
7	trypsin 1	2-606	N		MS	Schilling & Overall, 2008
17	trypsin 1	2-606	N		MS	Schilling & Overall, 2008
43	trypsin 1	2-606	N		MS	Schilling & Overall, 2008
65	trypsin 1	2-606	N		MS	Schilling & Overall, 2008
134	cathepsin L	127-147	N		MS	Biniossek et al., 2011
356	meprin alpha subunit	2-606	N		MS	Becker-Pauly et al., 2011
356	meprin beta subunit	2-606	N		MS	Becker-Pauly et al., 2011
473	cathepsin B	471-484	N		MS	Biniossek et al., 2011