Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O60664

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-434	P	release of an initiating methionine	MS	Gevaert et al., 2006
9	caspase-1	1-434	N		MS	Agard et al., 2010
68	trypsin 1	2-434	N		MS	Schilling & Overall, 2008
84	trypsin 1	2-434	N		MS	Schilling & Overall, 2008
98	trypsin 1	2-434	N		MS	Schilling & Overall, 2008
128	trypsin 1	2-434	N		MS	Schilling & Overall, 2008
140	trypsin 1	2-434	N		MS	Schilling & Overall, 2008
180	trypsin 1	2-434	N		MS	Schilling & Overall, 2008
195	trypsin 1	2-434	N		MS	Schilling & Overall, 2008
219	unknown peptidase	1-434	P		MS	Mahrus et al., 2008