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Literature for family C2

Family

Summary Holotypes Alignment Tree Genomes Structure Literature H-seq M-seq Architecture

C2A

Summary Holotypes Alignment Tree Genomes Literature

(Topics flags: A Assay, T Target, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Coria,M.S. and Grigioni,G.M.
    Casein Zymography: A Rapid and Robust Methodology for Detecting Calpain Protease Activity in Meat Product
    Methods Mol Biol2918, 125-131. PubMed  Europe PubMed DOI  L
    2. 2024
  2. Zhang,X., Zheng,Y., Wang,Z., Zhang,G., Yang,L., Gan,J. and Jiang,X.
    Calpain: The regulatory point of cardiovascular and cerebrovascular diseases
    Biomed Pharmacother179, 117272-117272. PubMed  Europe PubMed DOI  V
    3. 2023
  3. Knaryan,V.H. and Sarukhanyan,F.P.
    [Ca2+-regulated enzymes calpain and calcineurin in neurodegenerative processes and prospects for neuroprotective pharmacotherapy]
    Zh Nevrol Psikhiatr Im S S Korsakova123, 32-40. PubMed  Europe PubMed DOI  V
  4. Kotova,I.M., Pestereva,N.S., Traktirov,D.S., Absalyamova,M.T. and Karpenko,M.N.
    Functions and distribution of calpain-calpastatin system components in brain during mammal ontogeny
    Biochim Biophys Acta Gen Subj1867, 130345-130345. PubMed  Europe PubMed DOI  V
  5. Liu,G.Y., Xie,W.L., Wang,Y.T., Chen,L., Xu,Z.Z., Lv,Y. and Wu,Q.P.
    Calpain: the regulatory point of myocardial ischemia-reperfusion injury
    Front Cardiovasc Med10, 1194402-1194402. PubMed  Europe PubMed DOI
  6. Metaxas,G.I., Spyropoulou,D., Mastronikoli,S., Tsiambas,E., Falidas,E., Marinopoulos,S., Manaios,L., Davris,D., Fotiades,P., Peschos,D. and Dimitrakakis,C.
    Calpain-mediated Mechanoptosis in Breast Adenocarcinoma
    Cancer Diagn Progn3, 297-301. PubMed  Europe PubMed DOI  V
    7. 2022
  7. Veselenyiova,D., Hutarova,L., Lukacova,A., Schneiderova,M., Vesteg,M. and Krajcovic,J.
    Calpains in cyanobacteria and the origin of calpains
    Sci Rep12, 13872-13872. PubMed  Europe PubMed DOI
    8. 2021
  8. Metwally,E., Zhao,G. and Zhang,Y.Q.
    The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration
    Trends Neurosci44, 741-752. PubMed  Europe PubMed DOI  V
    9. 2020
  9. Dokus,L.E., Yousef,M. and Banoczi,Z.
    Modulators of calpain activity: inhibitors and activators as potential drugs
    Expert Opin Drug Discov15, 471-486. PubMed  Europe PubMed DOI  I
  10. Donkor,I.O.
    An update on the therapeutic potential of calpain inhibitors: a patent review
    Expert Opin Ther Pat PubMed  Europe PubMed DOI
    11. 2019
  11. Fan,Y.X., Pan,X., Zhang,Y. and Shen,H.B.
    LabCaS for ranking potential calpain substrate cleavage sites from amino acid sequence
    Methods Mol Biol1915, 111-120. PubMed  Europe PubMed DOI  P
  12. McCartney,C.E. and Davies,P.L.
    Bacterial expression and purification of calpains
    Methods Mol Biol1915, 13-27. PubMed  Europe PubMed DOI  E
  13. McCartney,C.E. and Davies,P.L.
    FRET-based assays to determine calpain activity
    Methods Mol Biol1915, 39-55. PubMed  Europe PubMed DOI  A
    14. 2017
  14. Hastings,M.H., Gong,K., Freibauer,A., Courchesne,C., Fan,X. and Sossin,W.S.
    Novel calpain families and novel mechanisms for calpain regulation in Aplysia
    PLoS ONE12, e0186646-e0186646. PubMed  Europe PubMed DOI
  15. Wang,K.K.W.
    Calpain zymography: general methodology and protocol
    Methods Mol Biol1626, 279-285. PubMed  Europe PubMed DOI  L
    16. 2016
  16. Ono,Y., Saido,T.C. and Sorimachi,H.
    Calpain research for drug discovery: challenges and potential
    Nat Rev Drug Discov15, 854-876. PubMed  Europe PubMed DOI  I
    17. 2015
  17. Rawlings,N.D.
    Bacterial calpains and the evolution of the calpain (C2) family of peptidases
    Biol Direct10, 66-66. PubMed  Europe PubMed DOI
    18. 2014
  18. MacQueen,D.J. and Wilcox,A.H.
    Characterization of the definitive classical calpain family of vertebrates using phylogenetic, evolutionary and expression analyses
    Open Biol4, 130219-130219. PubMed  Europe PubMed DOI
    19. 2013
  19. Fan,Y.X., Zhang,Y. and Shen,H.B.
    LabCaS: labeling calpain substrate cleavage sites from amino acid sequence using conditional random fields
    Proteins81, 622-634. PubMed  Europe PubMed DOI
    20. 2012
  20. Ono,Y. and Sorimachi,H.
    Calpains: an elaborate proteolytic system
    Biochim Biophys Acta1824, 224-236. PubMed  Europe PubMed DOI
  21. Sorimachi,H. and Ono,Y.
    Regulation and physiological roles of the calpain system in muscular disorders
    Cardiovasc Res96, 11-22. PubMed  Europe PubMed DOI  V
  22. Wee,L.J.K. and Low,H.M.
    SVM-based prediction of the calpain degradome using Bayes feature extraction
    Proc Annu Int Conf IEEE Eng Med Biol Soc EMBS2012, 5534-5540. PubMed  Europe PubMed DOI  P
  23. Zhao,S., Liang,Z., Demko,V., Wilson,R., Johansen,W., Olsen,O.A. and Shalchian-Tabrizi,K.
    Massive expansion of the calpain gene family in unicellular eukaryotes
    BMC Evol Biol12, 193-193. PubMed  Europe PubMed DOI
    24. 2011
  24. Sorimachi,H., Hata,S. and Ono,Y.
    Impact of genetic insights into calpain biology
    J Biochem150, 23-37. PubMed  Europe PubMed DOI
  25. Sorimachi,H., Hata,S. and Ono,Y.
    Calpain chronicle - an enzyme family under multidisciplinary characterization
    Proc Jpn Acad Ser B Phys Biol Sci87, 287-327. PubMed  Europe PubMed DOI
    26. 2010
  26. duVerle,D., Takigawa,I., Ono,Y., Sorimachi,H. and Mamitsuka,H.
    CaMPDB: a resource for calpain and modulatory proteolysis
    Genome Inform22, 202-213. PubMed  Europe PubMed
  27. Kar,P., Samanta,K., Shaikh,S., Chowdhury,A., Chakraborti,T. and Chakraborti,S.
    Mitochondrial calpain system: an overview
    Arch Biochem Biophys495, 1-7. PubMed  Europe PubMed DOI
  28. Liu,W., Apagyi,K., McLeavy,L. and Ersfeld,K.
    Expression and cellular localisation of calpain-like proteins in Trypanosoma brucei
    Mol Biochem Parasitol169, 20-26. PubMed  Europe PubMed DOI
  29. Nemova,N.N., Lysenko,L.A. and Kantserova,N.P.
    Proteases of the calpain family: structure and functions
    Russ J Dev Biol41, 318-325. DOI  V
  30. Sorimachi,H., Hata,S. and Ono,Y.
    Expanding members and roles of the calpain superfamily and their genetically modified animals
    Exp Anim59, 549-566. PubMed  Europe PubMed DOI
    31. 2008
  31. Bondareva,L.A. and Nemova,N.N.
    Molecular evolution of intracellular Ca2+-dependent proteases
    Russ J Bioorganic Chem34, 266-273. DOI
  32. Bondareva,L.A. and Nemova,N.N.
    [Molecular evolution of intracellular Ca2+-dependent proteases]
    Bioorg Khim34, 295-302. PubMed  Europe PubMed
    33. 2007
  33. Croall,D.E. and Ersfeld,K.
    The calpains: modular designs and functional diversity
    Genome Biol8, 218-218. PubMed  Europe PubMed DOI  V
  34. Evans,J.S. and Turner,M.D.
    Emerging functions of the calpain superfamily of cysteine proteases in neuroendocrine secretory pathways
    J Neurochem103, 849-859. PubMed  Europe PubMed DOI  V
    35. 2006
  35. Benyamin,Y.
    The structural basis of calpain behavior
    FEBS J273, 3413-3414. PubMed  Europe PubMed DOI  V
  36. Carragher,N.O.
    Calpain inhibition: a therapeutic strategy targeting multiple disease states
    Curr Pharm Des12, 615-638. PubMed  Europe PubMed DOI  V  I
  37. Saez,M.E., Ramirez-Lorca,R., Moron,F.J. and Ruiz,A.
    The therapeutic potential of the calpain family: new aspects
    Drug Discov Today11, 917-923. PubMed  Europe PubMed DOI  T  U
    38. 2005
  38. Ersfeld,K., Barraclough,H. and Gull,K.
    Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites
    J Mol Evol61, 742-757. PubMed  Europe PubMed DOI
  39. Mehendale,H.M. and Limaye,P.B.
    Calpain: a death protein that mediates progression of liver injury
    Trends Pharmacol Sci26, 232-236. PubMed  Europe PubMed DOI  V
  40. Neffe,A.T. and Abell,A.D.
    Developments in the design and synthesis of calpain inhibitors
    Curr Opin Drug Discov Devel8, 684-700. PubMed  Europe PubMed  V
    41. 2004
  41. Liu,X., Van Vleet,T. and Schnellmann,R.G.
    The role of calpain in oncotic cell death
    Annu Rev Pharmacol Toxicol44, 349-370. PubMed  Europe PubMed DOI
  42. [YEAR:14-5-2004]Tompa,P., Buzder-Lantos,P., Tantos,A., Farkas,A., Szilagyi,A., Banoczi,Z., Hudecz,F. and Friedrich,P.
    On the sequential determinants of calpain cleavage
    J Biol Chem279, 20775-20785. PubMed  Europe PubMed DOI  P
    43. 2003
  43. Goll,D.E., Thompson,V.F., Li,H., Wei,W. and Cong,J.
    The calpain system
    Physiol Rev83, 731-801. PubMed  Europe PubMed DOI
  44. Weedon,M.N., Schwarz,P.E., Horikawa,Y., Iwasaki,N., Illig,T., Holle,R., Rathmann,W., Selisko,T., Schulze,J., Owen,K.R., Evans,J., del Bosque-Plata,L., Hitman,G., Walker,M., Levy,J.C., Sampson,M., Bell,G.I., McCarthy,M.I., Hattersley,A.T. and Frayling,T.M.
    Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility
    Am J Hum Genet73, 1208-1212. PubMed  Europe PubMed DOI  M
    45. 2002
  45. Glading,A., Lauffenburger,D.A. and Wells,A.
    Cutting to the chase: calpain proteases in cell motility
    Trends Cell Biol12, 46-54. PubMed  Europe PubMed DOI
    46. 2001
  46. Huang,Y. and Wang,K.K.
    The calpain family and human disease
    Trends Mol Med7, 355-362. PubMed  Europe PubMed DOI
  47. Sorimachi,H. and Suzuki,K.
    The structure of calpain
    J Biochem129, 653-664. PubMed  Europe PubMed
    48. 2000
  48. Zimmerman,U.J., Boring,L., Pak,J.H., Mukerjee,N. and Wang,K.K.
    The calpain small subunit gene is essential: Its inactivation results in embryonic lethality
    IUBMB Life50, 63-68. PubMed  Europe PubMed DOI
    49. 1999
  49. Jekely,G. and Friedrich,P.
    The evolution of the calpain family as reflected in paralogous chromosome regions
    J Mol Evol49, 272-281. PubMed  Europe PubMed DOI
    50. 1998
  50. [YEAR:17-4-1998]Ono,Y., Sorimachi,H. and Suzuki,K.
    Structure and physiology of calpain, an enigmatic protease
    Biochem Biophys Res Commun245, 289-294. PubMed  Europe PubMed DOI
    51. 1997
  51. [YEAR:15-12-1997]Sorimachi,H., Ishiura,S. and Suzuki,K.
    Structure and physiological function of calpains
    Biochem J328, 721-732. PubMed  Europe PubMed
    52. 1995
  52. Suzuki,K., Sorimachi,H., Yoshizawa,T., Kinbara,K. and Ishiura,S.
    Calpain: Novel family members, activation, and physiologic function
    Biol Chem Hoppe Seyler376, 523-529. PubMed  Europe PubMed
    53. 1994
  53. [YEAR:7-10-1994]Delaria,K., Fiorentino,L., Wallace,L., Tamburini,P., Brownell,E. and Muller,D.
    Inhibition of cathepsin L-like cysteine proteases by cytotoxic T-lymphocyte antigen-2 beta
    J Biol Chem269, 25172-25177. PubMed  Europe PubMed
    54. 1992
  54. Goll,D.E., Thompson,V.F., Taylor,R.G. and Zalewska,T.
    Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin?
    Bioessays14, 549-556. PubMed  Europe PubMed DOI
    55. 1978
  55. [YEAR:30-5-1978]Toyo-oka,T., Shimizu,T. and Masaki,T.
    Inhibition of proteolytic activity of calcium activated neutral protease by leupeptin and antipain
    Biochem Biophys Res Commun82, 484-491. PubMed  Europe PubMed  I

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