Literature for peptidase C01.036: cathepsin K

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2026
1. Soundararajan,A., Jayasankar,K., Doud,E.H., Pasteurin,R.P., Surma,M. and Pattabiraman,P.P.
   Loss of Cathepsin K Impairs Collagen Biogenesis and Enhances Actin Polymerization in Trabecular Meshwork
   Invest Ophthalmol Vis Sci (2026) 67, 63-63. PubMed  Europe PubMed DOI  PMC  EPMC  K
2025
2. Ma,L., Lu,B., Si,Y., Dai,L., Tan,M., Liu,W., Sun,D., Shu,J., Chen,C., Xiang,Q., Jiang,D., Wei,X. and Wang,W.E.
   Cathepsin K as a key regulator of myocardial fibrosis in dilated cardiomyopathy and a promising therapeutic target
   J Biol Chem (2025) 301, 110421-110421. PubMed  Europe PubMed DOI  PMC  EPMC  K
3. Soundararajan,A., Jaysankar,K., Doud,E., Pasteurin,R.P., Surma,M. and Pattabiraman,P.P.
   Loss of Cathepsin K impairs collagen biogenesis and enhances actin polymerization in trabecular meshwork
   bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC  K
2023
4. Seo,S.U., Woo,S.M. and Kwon,T.K.
   Cathepsin K inhibition induces Raptor destabilization and mitochondrial dysfunction via Syk/SHP2/Src/OTUB1 axis-mediated signaling
   Cell Death Dis (2023) 14, 366-366. PubMed  Europe PubMed DOI  PMC  EPMC  K
2022
5. Seo,S.U., Woo,S.M., Lee,S.G., Kim,M.Y., Lee,H.S., Choi,Y.H., Kim,S.H., Chang,Y.C., Min,K.J. and Kwon,T.K.
   BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation
   Redox Biol (2022) 53, 102336-102336. PubMed  Europe PubMed DOI  PMC  EPMC  K
2020
6. Yue,X., Jiang,H., Xu,Y., Xia,M. and Cheng,X.W.
   Cathepsin K Deficiency Impaired Ischemia-Induced Neovascularization in Aged Mice
   Stem Cells Int (2020) 2020, 6938620-6938620. PubMed  Europe PubMed DOI  PMC  EPMC  K
2019
7. Lotinun,S., Ishihara,Y., Nagano,K., Kiviranta,R., Carpentier,V.T., Neff,L., Parkman,V., Ide,N., Hu,D., Dann,P., Brooks,D., Bouxsein,M.L., Wysolmerski,J., Gori,F. and Baron,R.
   Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression
   J Clin Invest (2019) 129, 3058-3071. PubMed  Europe PubMed DOI  K
2018
8. Guo,R., Hua,Y., Ren,J., Bornfeldt,K.E. and Nair,S.
   Cardiomyocyte-specific disruption of cathepsin K protects against doxorubicin-induced cardiotoxicity
   Cell Death Dis (2018) 9, 692-692. PubMed  Europe PubMed DOI  PMC  EPMC  K
9. Ogasawara,S., Cheng,X.W., Inoue,A., Hu,L., Piao,L., Yu,C., Goto,H., Xu,W., Zhao,G., Lei,Y., Yang,G., Kimura,K., Umegaki,H., Shi,G.P. and Kuzuya,M.
   Cathepsin K activity controls cardiotoxin-induced skeletal muscle repair in mice
   J Cachexia Sarcopenia Muscle (2018) 9, 160-175. PubMed  Europe PubMed DOI  K
10. Walia,B., Lingenheld,E., Duong,L., Sanjay,A. and Drissi,H.
    A novel role for cathepsin K in periosteal osteoclast precursors during fracture repair
    Ann N Y Acad Sci (2018) 1415, 57-68. PubMed  Europe PubMed DOI  K
2017
11. Guo,R., Hua,Y., Rogers,O., Brown,T.E., Ren,J. and Nair,S.
    Cathepsin K knockout protects against cardiac dysfunction in diabetic mice
    Sci Rep (2017) 7, 8703-8703. PubMed  Europe PubMed DOI  PMC  EPMC  K
12. Zhou,Y., Chen,H., Liu,L., Yu,X., Sukhova,G.K., Yang,M., Kyttaris,V.C., Stillman,I.E., Gelb,B., Libby,P., Tsokos,G.C. and Shi,G.P.
    Cathepsin K deficiency ameliorates systemic lupus erythematosus-like manifestations in Fas(lpr) mice
    J Immunol (2017) 198, 1846-1854. PubMed  Europe PubMed DOI  K
2016
13. Chen,W., Gao,B., Hao,L., Zhu,G., Jules,J., MacDougall,M.J., Wang,J., Han,X., Zhou,X. and Li,Y.P.
    The silencing of cathepsin K used in gene therapy for periodontal disease reveals the role of cathepsin K in chronic infection and inflammation
    J Periodontal Res (2016) 51, 647-660. PubMed  Europe PubMed DOI  K  T
2015
14. Hao,L., Zhu,G., Lu,Y., Wang,M., Jules,J., Zhou,X. and Chen,W.
    Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role
    FEBS Lett (2015) 589, 1331-1339. PubMed  Europe PubMed DOI  K
15. Hua,Y., Robinson,T.J., Cao,Y., Shi,G.P., Ren,J. and Nair,S.
    Cathepsin K knockout alleviates aging-induced cardiac dysfunction
    Aging Cell (2015) 14, 345-351. PubMed  Europe PubMed DOI  K
2014
16. Hu,L., Cheng,X.W., Song,H., Inoue,A., Jiang,H., Li,X., Shi,G.P., Kozawa,E., Okumura,K. and Kuzuya,M.
    Cathepsin K activity controls injury-related vascular repair in mice
    Hypertension (2014) 63, 607-615. PubMed  Europe PubMed DOI  K
17. Jacome-Galarza,C., Soung,d.Y., Adapala,N.S., Pickarski,M., Sanjay,A., Duong,l.T., Lorenzo,J.A. and Drissi,H.
    Altered hematopoietic stem cell and osteoclast precursor frequency in cathepsin K null mice
    J Cell Biochem (2014) 115, 1449-1457. PubMed  Europe PubMed DOI  K
2013
18. 
    Activating cathepsin K in osteoclasts stimulates bone formation through S1P
    Bonekey Rep (2013) 2, 362-362. PubMed  Europe PubMed DOI  PMC  EPMC  K
19. Gao,B., Chen,W., Hao,L., Zhu,G., Feng,S., Ci,H., Zhou,X., Stashenko,P. and Li,Y.P.
    Inhibiting periapical lesions through AAV-RNAi silencing of cathepsin K
    J Dent Res (2013) 92, 180-186. PubMed  Europe PubMed DOI  K
20. Herroon,M.K., Rajagurubandara,E., Rudy,D.L., Chalasani,A., Hardaway,A.L. and Podgorski,I.
    Macrophage cathepsin K promotes prostate tumor progression in bone
    Oncogene (2013) 32, 1580-1593. PubMed  Europe PubMed DOI  K
21. Hua,Y., Zhang,Y., Dolence,J., Shi,G.P., Ren,J. and Nair,S.
    Cathepsin K knockout mitigates high-fat diet-induced cardiac hypertrophy and contractile dysfunction
    Diabetes (2013) 62, 498-509. PubMed  Europe PubMed DOI  K
22. Hua,Y., Xu,X., Shi,G.P., Chicco,A.J., Ren,J. and Nair,S.
    Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy
    Hypertension (2013) 61, 1184-1192. PubMed  Europe PubMed DOI  K
23. Lotinun,S., Kiviranta,R., Matsubara,T., Alzate,J.A., Neff,L., Luth,A., Koskivirta,I., Kleuser,B., Vacher,J., Vuorio,E., Horne,W.C. and Baron,R.
    Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation
    J Clin Invest (2013) 123, 666-681. PubMed  Europe PubMed DOI  K
24. Miller,R.E., Lu,Y., Tortorella,M.D. and Malfait,A.M.
    Genetically engineered mouse models reveal the importance of proteases as osteoarthritis drug targets
    Curr Rheumatol Rep (2013) 15, 350-350. PubMed  Europe PubMed DOI  K
2012
25. Arampatzidou,M., Schutte,A., Hansson,G.C., Saftig,P. and Brix,K.
    Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon
    Biol Chem (2012) 393, 1391-1403. PubMed  Europe PubMed DOI  K
26. Dauth,S., Schmidt,M.M., Rehders,M., Dietz,F., Kelm,S., Dringen,R. and Brix,K.
    Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice
    Biol Chem (2012) 393, 959-970. PubMed  Europe PubMed DOI  K
27. Kozawa,E., Nishida,Y., Cheng,X.W., Urakawa,H., Arai,E., Futamura,N., Shi,G.P., Kuzuya,M., Hu,L., Sasaki,T. and Ishiguro,N.
    Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis
    Arthritis Rheum (2012) 64, 454-464. PubMed  Europe PubMed DOI  K
28. Winkeler,C.L., Kladney,R.D., Maggi,L.B., Jr. and Weber,J.D.
    Cathepsin K-cre causes unexpected germline deletion of genes in mice
    PLoS ONE (2012) 7, e42005-e42005. PubMed  Europe PubMed DOI  PMC  EPMC  K
29. Zhang,Y., Li,J., Zhu,J., Zhou,G., Zhang,W.J., Cao,Y. and Liu,W.
    Enhanced cartilage formation by inhibiting cathepsin K expression in chondrocytes expanded invitro
    Biomaterials (2012) 33, 7394-7404. PubMed  Europe PubMed DOI  K
2011
30. Dauth,S., Sirbulescu,R.F., Jordans,S., Rehders,M., Avena,L., Oswald,J., Lerchl,A., Saftig,P. and Brix,K.
    Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits
    BMC Neurosci (2011) 12, 74-74. PubMed  Europe PubMed DOI  K
31. Knaapi,J., Lukkarinen,H., Kiviranta,R., Vuorio,E. and Kaapa,P.
    Cathepsin K deficiency aggravates lung injury in hyperoxia-exposed newborn mice
    Exp Lung Res (2011) 37, 408-418. PubMed  Europe PubMed DOI  K
32. Zhang,D., Leung,N., Weber,E., Saftig,P. and Bromme,D.
    The effect of cathepsin K deficiency on airway development and TGF-beta1 degradation
    Respir Res (2011) 12, 72-72. PubMed  Europe PubMed DOI  K
2010
33. Bai,L., Beckers,L., Wijnands,E., Lutgens,S.P., Herias,M.V., Saftig,P., Daemen,M.J., Cleutjens,K., Lutgens,E., Biessen,E.A. and Heeneman,S.
    Cathepsin K gene disruption does not affect murine aneurysm formation
    Atherosclerosis (2010) 209, 96-103. PubMed  Europe PubMed DOI  K
2009
34. Pennypacker,B., Shea,M., Liu,Q., Masarachia,P., Saftig,P., Rodan,S., Rodan,G. and Kimmel,D.
    Bone density, strength, and formation in adult cathepsin K (-/-) mice
    Bone (2009) 44, 199-207. PubMed  Europe PubMed DOI  K
2008
35. Samokhin,A.O., Wong,A., Saftig,P. and Bromme,D.
    Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice
    Atherosclerosis (2008) 200, 58-68. PubMed  Europe PubMed DOI  K
36. Schurigt,U., Hummel,K.M., Petrow,P.K., Gajda,M., Stockigt,R., Middel,P., Zwerina,J., Janik,T., Bernhardt,R., Schuler,S., Scharnweber,D., Beckmann,F., Saftig,P., Kollias,G., Schett,G., Wiederanders,B. and Brauer,R.
    Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice
    Arthritis Rheum (2008) 58, 422-434. PubMed  Europe PubMed DOI  K
2007
37. Funicello,M., Novelli,M., Ragni,M., Vottari,T., Cocuzza,C., Soriano-Lopez,J., Chiellini,C., Boschi,F., Marzola,P., Masiello,P., Saftig,P., Santini,F., St-Jacques,R., Desmarais,S., Morin,N., Mancini,J., Percival,M.D., Pinchera,A. and Maffei,M.
    Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores
    PLoS ONE (2007) 2, e683-e683. PubMed  Europe PubMed DOI  PMC  EPMC  K
2006
38. Li,C.Y., Jepsen,K.J., Majeska,R.J., Zhang,J., Ni,R., Gelb,B.D. and Schaffler,M.B.
    Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass
    J Bone Miner Res (2006) 21, 865-875. PubMed  Europe PubMed DOI  K
39. [YEAR:19-12-2006]Lutgens,E., Lutgens,S.P., Faber,B.C., Heeneman,S., Gijbels,M.M., de Winther,M.P., Frederik,P., van der Made,I., Daugherty,A., Sijbers,A.M., Fisher,A., Long,C.J., Saftig,P., Black,D., Daemen,M.J. and Cleutjens,K.B.
    Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation
    Circulation (19-12-2006) 113, 98-107. PubMed  Europe PubMed DOI  K
40. [YEAR:14-9-2006]Lutgens,S.P., Kisters,N., Lutgens,E., van Haaften,R.I., Evelo,C.T., de Winther,M.P., Saftig,P., Daemen,M.J., Heeneman,S. and Cleutjens,K.B.
    Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic
    J Pathol (14-9-2006) 210, 334-343. PubMed  Europe PubMed DOI  K
2005
41. Morko,J., Kiviranta,R., Joronen,K., Saamanen,A.M., Vuorio,E. and Salminen-Mankonen,H.
    Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K
    Arthritis Rheum (2005) 52, 3713-3717. PubMed  Europe PubMed DOI  K
2000
42. Fujita,Y., Nakata,K., Yasui,N., Matsui,Y., Kataoka,E., Hiroshima,K., Shiba,R.I. and Ochi,T.
    Novel mutations of the cathepsin K gene in patients with pycnodysostosis and their characterization
    J Clin Endocrinol Metab (2000) 85, 425-431. PubMed  Europe PubMed DOI  K  M
43. Saftig,P., Hunziker,E., Everts,V., Jones,S., Boyde,A., Wehmeyer,O., Suter,A. and von Figura,K.
    Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice
    Adv Exp Med Biol (2000) 477, 293-303. PubMed  Europe PubMed DOI  K
1998
44. [YEAR:10-11-1998]Saftig,P., Hunziker,E., Wehmeyer,O., Jones,S., Boyde,A., Rommerskirch,W., Moritz,J.D., Schu,P. and von Figura,K.
    Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
    Proc Natl Acad Sci U S A (10-11-1998) 95, 13453-13458. PubMed  Europe PubMed DOI  PMC  EPMC  K
1997
45. Inui,T., Ishibashi,O., Inaoka,T., Origane,Y., Kumegawa,M., Kokubo,T. and Yamamura,T.
    Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption
    J Biol Chem (1997) 272, 8109-8112. PubMed  Europe PubMed DOI  K
1996
46. Johnson,M.R., Polymeropoulos,M.H., Vos,H.L., Ortiz de Luna,R.I. and Francomano,C.A.
    A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis
    Genome Res (1996) 6, 1050-1055. PubMed  Europe PubMed  K  M