$VAR1 = undef;

Summary for peptidase S26.009: signalase (animal) 18 kDa component

Names
MEROPS Name	signalase (animal) 18 kDa component
Other names	leader peptidase, Sec11 g.p. (Saccharomyces cerevisiae), signal peptidase complex 18 kDa component, SPC18

Domain architecture

MEROPS Classification
Classification	Clan SF >> Subclan (none) >> Family S26 >> Subfamily B >> S26.009
Holotype	signalase (animal) 18 kDa component (Canis lupus familiaris), Uniprot accession P67811 (peptidase unit: 44-179), MERNUM MER0000600
History	Identifier created: MEROPS 5.0 (17 April 2000)

Activity
Catalytic type	Serine
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.89
Enzymology	BRENDA database
Activity status	human: active (Liang et al., 2003) mouse: active (by similarity to dog) (Liang et al., 2003)
Pharmaceutical relevance	'The revelation of signal peptidase involved in HCV polyprotein processing presents a novel drug target to suppress HCV viral replication for the much needed HCV therapy' (Wu, 2001).
Pathways	KEGG	Protein export
Other databases	TREEFAM	http://www.treefam.org/family/TF313648