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human RNA polymerase III pre-initiation complex closed DNA 1
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8ity
Q-score: 0.291
Hou H, Jin Q, Ren Y, Chen Z, Wang Q, Xu Y
Cell Res (2023) 33 pp. 565-568 [ DOI: doi:10.1038/s41422-023-00819-x Pubmed: 37165065 ]
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
- Dna (82-mer) (143 kDa, DNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
- Dna (Complex)
- Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
- Rna polymerase iii pre-initiation complex closed complex 1 (Complex)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc4 (35 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
- Rna polymerase iii pre-initiation complex closed complex 1 (1 MDa, Complex from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc5 (80 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 4 (159 kDa, Protein from Homo sapiens)
- Transcription factor tfiiib component b'' homolog (294 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
- Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
- Dna (82-mer) (143 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)
- Transcription factor iiib 50 kda subunit (46 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
RNA polymerase III pre-initiation complex melting complex 1
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8iue
Q-score: 0.291
Hou H, Jin Q, Ren Y, Chen Z, Wang Q, Xu Y
Cell Res (2023) 33 pp. 565-568 [ DOI: doi:10.1038/s41422-023-00819-x Pubmed: 37165065 ]
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase (Complex)
- Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
- Human gene for u 6 rna (143 kDa, DNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
- Dna (Complex)
- Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc4 (35 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
- Rna polymerase iii pre-initiation complex melting complex 1 (1 MDa, Complex from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc5 (80 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna (74-mer) (143 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 4 (159 kDa, Protein from Homo sapiens)
- Transcription factor tfiiib component b'' homolog (294 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
- Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
- Transcription factor (Complex)
- Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)
- Transcription factor iiib 50 kda subunit (46 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
RNA polymerase III pre-initiation complex open complex 1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8iuh
Q-score: 0.341
Hou H, Jin Q, Ren Y, Chen Z, Wang Q, Xu Y
Cell Res (2023) 33 pp. 565-568 [ DOI: doi:10.1038/s41422-023-00819-x Pubmed: 37165065 ]
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Tfiiib (Complex)
- Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
- Dna (Complex)
- Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc4 (35 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
- Dna (81-mer) (143 kDa, DNA from Homo sapiens)
- Rna polymerase iii pre-initiation complex closed complex 1 (1 MDa, Complex from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc5 (80 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
- Dna (81-mer) (143 kDa, DNA from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 4 (159 kDa, Protein from Homo sapiens)
- Transcription factor tfiiib component b'' homolog (294 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
- Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii, snapc (Complex)
- Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)
- Transcription factor iiib 50 kda subunit (46 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7zx8
Q-score: 0.356
Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P
Nat Struct Mol Biol (2022) 29 pp. 1159-1169 [ DOI: doi:10.1038/s41594-022-00857-w Pubmed: 36424526 ]
- Rna polymerase ii subunit j (13 kDa, Protein from pig)
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Snapc (Complex from Homo sapiens)
- Rna polymerase ii subunit k (7 kDa, Protein from pig)
- Dna-directed rna polymerase ii subunit rpb7 (19 kDa, Protein from pig)
- Non-template strand (29 kDa, DNA from Homo sapiens)
- Transcription initiation factor iia subunit 2 (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Transcription initiation factor iib (34 kDa, Protein from Homo sapiens)
- Template strand (29 kDa, DNA from Homo sapiens)
- Rna polymerase ii (Complex from Homo sapiens)
- Dna-directed rna polymerase ii subunit f (14 kDa, Protein from pig)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase subunit beta (134 kDa, Protein from pig)
- Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from pig)
- Snrna-activating protein complex subunit 5 (11 kDa, Protein from Homo sapiens)
- Transcription initiation factor iia subunit 1 (41 kDa, Protein from Homo sapiens)
- General transcription factor iif subunit 1 (58 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit e (24 kDa, Protein from pig)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from pig)
- Tata-box-binding protein and transcription factors (Complex from Homo sapiens)
- Dna-directed rna polymerase subunit (217 kDa, Protein from pig)
- Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from pig)
- Promoter (Complex from Sus scrofa)
- Rna polymerase ii subunit d (16 kDa, Protein from pig)
- Snrna-activating protein complex subunit 4 (159 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from pig)
- Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
- General transcription factor iif subunit 2 (28 kDa, Protein from Homo sapiens)
- Pre-initiation complex of rna polymerase ii with general transcription factors and snapc bound to u1 promoter (Complex)
- Magnesium ion (24 Da, Ligand)
The cryo-EM structure of human mini-SNAPc in complex with hU6-1 PSE
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 7xur
Q-score: 0.474
Sun J, Li X, Hou X, Cao S, Cao W, Zhang Y, Song J, Wang M, Wang H, Yan X, Li Z, Roeder RG, Wang W
Nat Commun (2022) 13 pp. 6871-6871 [ Pubmed: 36369505 DOI: doi:10.1038/s41467-022-34639-1 ]
- The complex of human mini-snapc with hu6-1 pse (Complex)
- Dna (35-mer) (10 kDa, DNA from synthetic construct)
- Snrna-activating protein complex subunit 1 (33 kDa, Protein from Homo sapiens)
- Dna (35-mer) (10 kDa, DNA from synthetic construct)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Human mini-snapc (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Snrna-activating protein complex subunit 4 (60 kDa, Protein from Homo sapiens)
- Dna (Complex)
Structure of SNAPc:TBP-TFIIA-TFIIB sub-complex bound to U5 snRNA promoter
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7zwc
Q-score: 0.452
Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P
Nat Struct Mol Biol (2022) 29 pp. 1159-1169 [ DOI: doi:10.1038/s41594-022-00857-w Pubmed: 36424526 ]
- Transcription initiation factor iib (34 kDa, Protein from Homo sapiens)
- Transcription initiation factor iia subunit 1 (41 kDa, Protein from Homo sapiens)
- Snapc (Complex from Homo sapiens)
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Transcription initiation factor iia subunit 2 (12 kDa, Protein from Homo sapiens)
- General transcription factors and snapc bound to u5 promoter (Complex)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Non-template strand (29 kDa, DNA from Homo sapiens)
- Template strand (29 kDa, DNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Tata-box-binding protein and transcription factors (Complex from Homo sapiens)
- Promoter (Complex from Homo sapiens)
- Snrna-activating protein complex subunit 4 (159 kDa, Protein from Homo sapiens)
- Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 5 (11 kDa, Protein from Homo sapiens)
Structure of SNAPc containing Pol II pre-initiation complex bound to U5 snRNA promoter (CC)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7zwd
Q-score: 0.342
Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P
Nat Struct Mol Biol (2022) 29 pp. 1159-1169 [ DOI: doi:10.1038/s41594-022-00857-w Pubmed: 36424526 ]
- Rna polymerase ii subunit j (13 kDa, Protein from pig)
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Snapc (Complex from Homo sapiens)
- Rna polymerase ii subunit k (7 kDa, Protein from pig)
- Dna-directed rna polymerase ii subunit rpb7 (19 kDa, Protein from pig)
- Transcription initiation factor iia subunit 2 (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Transcription initiation factor iib (34 kDa, Protein from Homo sapiens)
- Rna polymerase ii (Complex from Homo sapiens)
- Dna-directed rna polymerase ii subunit f (14 kDa, Protein from pig)
- Non-template strand (29 kDa, DNA from Homo sapiens)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase subunit beta (134 kDa, Protein from pig)
- Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from pig)
- Snrna-activating protein complex subunit 5 (11 kDa, Protein from Homo sapiens)
- Transcription initiation factor iia subunit 1 (41 kDa, Protein from Homo sapiens)
- General transcription factor iif subunit 1 (58 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit e (24 kDa, Protein from pig)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from pig)
- Tata-box-binding protein and transcription factors (Complex from Homo sapiens)
- Dna-directed rna polymerase subunit (217 kDa, Protein from pig)
- Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from pig)
- Promoter (Complex from Sus scrofa)
- Rna polymerase ii subunit d (16 kDa, Protein from pig)
- Snrna-activating protein complex subunit 4 (159 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from pig)
- Pre-initiation complex of rna polymerase ii with general transcription factors and snapc bound to u5 promoter (Complex)
- Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
- General transcription factor iif subunit 2 (28 kDa, Protein from Homo sapiens)
- Template strand (29 kDa, DNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (CC)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7zx7
Q-score: 0.267
Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P
Nat Struct Mol Biol (2022) 29 pp. 1159-1169 [ DOI: doi:10.1038/s41594-022-00857-w Pubmed: 36424526 ]
- Rna polymerase ii subunit j (13 kDa, Protein from pig)
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Snapc (Complex from Homo sapiens)
- Rna polymerase ii subunit k (7 kDa, Protein from pig)
- Dna-directed rna polymerase ii subunit rpb7 (19 kDa, Protein from pig)
- Non-template strand (29 kDa, DNA from Homo sapiens)
- Transcription initiation factor iia subunit 2 (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Transcription initiation factor iib (34 kDa, Protein from Homo sapiens)
- Template strand (29 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerase ii subunit f (14 kDa, Protein from pig)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase subunit beta (134 kDa, Protein from pig)
- Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from pig)
- Snrna-activating protein complex subunit 5 (11 kDa, Protein from Homo sapiens)
- Transcription initiation factor iia subunit 1 (41 kDa, Protein from Homo sapiens)
- General transcription factor iif subunit 1 (58 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit e (24 kDa, Protein from pig)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from pig)
- Tata-box-binding protein and transcription factors (Complex from Homo sapiens)
- Promoter (Complex from Homo sapiens)
- Dna-directed rna polymerase subunit (217 kDa, Protein from pig)
- Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from pig)
- Rna polymerase ii subunit d (16 kDa, Protein from pig)
- Snrna-activating protein complex subunit 4 (159 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from pig)
- Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
- General transcription factor iif subunit 2 (28 kDa, Protein from Homo sapiens)
- Pre-initiation complex of rna polymerase ii with general transcription factors and snapc bound to u1 promoter (Complex)
- Rna polymerase ii (Complex from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7zxe
Q-score: 0.333
Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P
Nat Struct Mol Biol (2022) 29 pp. 1159-1169 [ DOI: doi:10.1038/s41594-022-00857-w Pubmed: 36424526 ]
- Transcription initiation factor iib (34 kDa, Protein from Homo sapiens)
- Template strand (29 kDa, DNA from Homo sapiens)
- Snapc (Complex from Homo sapiens)
- Transcription initiation factor iia subunit 1 (41 kDa, Protein from Homo sapiens)
- Non-template strand (29 kDa, DNA from Homo sapiens)
- Snrna-activating protein complex subunit 1 (43 kDa, Protein from Homo sapiens)
- Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
- Transcription initiation factor iia subunit 2 (12 kDa, Protein from Homo sapiens)
- Snrna-activating protein complex subunit 3 (46 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Tata-box-binding protein and transcription factors (Complex from Homo sapiens)
- Promoter (Complex from Homo sapiens)
- Snrna-activating protein complex subunit 4 (159 kDa, Protein from Homo sapiens)
- General transcription factors and snapc bound to u1 promoter (Complex)
- Snrna-activating protein complex subunit 5 (11 kDa, Protein from Homo sapiens)