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Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7wuj
Q-score: 0.474
Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X
Nature (2022) 604 pp. 771-778 [ DOI: doi:10.1038/s41586-022-04590-8 Pubmed: 35418677 ]
- Nanobody-35 (13 kDa, Protein from Lama glama)
- Adhesion g-protein coupled receptor g4,uncharacterized protein (71 kDa, Protein from Psychromonas sp. B3M02)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Nanobody-35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Gs (Complex from Homo sapiens)
- Cryo-em structure of the adgr4-beta-gs complex (Complex)
cryo EM map of the S protein of SARS-CoV-2 in complex bound with P2B-1A10
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7czq
Q-score: 0.385
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ig c642_heavy_ighv3-53_ighd1-26_ighj6,chain h of p2b-1a10,immunoglobulin gamma-1 heavy chain (49 kDa, Protein from Homo sapiens)
- S protein of sars-cov-2 in complex bound with p2b-1a10 (Complex from Homo sapiens)
- Immunoglobulin kappa variable 1-33,uncharacterized protein (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
S protein of SARS-CoV-2 in complex bound with P5A-1B8_2B
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7czr
Q-score: 0.303
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- Ig c542_heavy_ighv3-53_ighd3-10_ighj6,igh@ protein (48 kDa, Protein from Homo sapiens)
- S protein of sars-cov-2 in complex bound with p5a-1b8_2b (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igl c4203_light_igkv1-9_igkj4,igl c4203_light_igkv1-9_igkj4,uncharacterized protein (23 kDa, Protein from Homo sapiens)
S protein of SARS-CoV-2 in complex bound with P5A-1B8_3B
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7czs
Q-score: 0.261
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- Ig c542_heavy_ighv3-53_ighd3-10_ighj6,igh@ protein (48 kDa, Protein from Homo sapiens)
- S protein of sars-cov-2 in complex bound with p5a-1b8_3b (Complex from Homo sapiens)
- Igl c4203_light_igkv1-9_igkj4,uncharacterized protein (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
S protein of SARS-CoV-2 in complex bound with P5A-1B6_2B
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7czu
Q-score: 0.324
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- Immunoglobulin kappa variable 1-33,immunoglobulin kappa variable 1-33,uncharacterized protein (23 kDa, Protein from Homo sapiens)
- S protein of sars-cov-2 in complex bound with p5a-1b6_2b (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Immunoglobulin heavy variable 3-30-3,immunoglobulin heavy variable 3-30-3,chain h of p5a-1b6_2b,immunoglobulin gamma-1 heavy chain,immunoglobulin gamma-1 heavy chain (49 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
S protein of SARS-CoV-2 in complex bound with P5A-1B6_3B
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7czv
Q-score: 0.26
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- Immunoglobulin kappa variable 1-33,uncharacterized protein (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S protein of sars-cov-2 in complex bound with p5a-1b6_3b (Complex from Homo sapiens)
- Immunoglobulin heavy variable 3-30-3,chain h of p5a-1b6_3b,immunoglobulin gamma-1 heavy chain (49 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
S protein of SARS-CoV-2 in complex bound with P5A-1B9
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7czx
Q-score: 0.333
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- S protein of sars-cov-2 in complex bound with p5a-1b9 (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ig c168_light_igkv4-1_igkj4,uncharacterized protein (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Immunoglobulin heavy variable 4-59,chain h of p5a-1b9,igh@ protein (50 kDa, Protein from Homo sapiens)
S protein of SARS-CoV-2 in complex bound with FabP5A-1B8
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7d00
Q-score: 0.36
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- Igl c4203_light_igkv1-9_igkj4,uncharacterized protein (23 kDa, Protein from Homo sapiens)
- Ig c642_heavy_ighv3-53_ighd1-26_ighj6,chain h of fabp5a-1b8,igh@ protein (48 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S protein of sars-cov-2 in complex bound with fabp5a-1b8 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)