Wildtype rabbit TRPV5 in nanodiscs in complex with oleoyl coenzyme A, Open stated
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8fhi
Q-score: 0.504
Lee BH, De Jesus Perez JJ, Moiseenkova-Bell V, Rohacs T
Nat Commun (2023) 14 pp. 5883-5883 [ Pubmed: 37735536 DOI: doi:10.1038/s41467-023-41577-z ]
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Tetramer of wildtype rabbit trpv5 in nanodiscs in complex with oleoyl coenzyme a (335 kDa, Complex from Oryctolagus cuniculus)
- Ergosterol (396 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
The structure of h12-LOX in tetrameric form bound to endogenous inhibitor oleoyl-CoA
Resolution: 2.05 Å
EM Method: Single-particle
Fitted PDBs: 8ghe
Q-score: 0.624
Mobbs JI, Black KA, Tran M, Burger WAC, Venugopal H, Holman TR, Holinstat M, Thal DM, Glukhova A
Blood (2023) 142 pp. 1233-1242 [ DOI: doi:10.1182/blood.2023020441 Pubmed: 37506345 ]
- Fe (ii) ion (55 Da, Ligand)
- Tetrameric human 12-lipoxygenase bound to endogenous inhibitor oleoyl-coa (300 kDa, Complex from Homo sapiens)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Water (18 Da, Ligand)
- Polyunsaturated fatty acid lipoxygenase alox12 (76 kDa, Protein from Homo sapiens)
Cryo-EM structure of oleoyl-CoA-bound human peroxisomal fatty acid transporter ABCD1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7shn
Q-score: 0.501
Cell Res (2022) 32 pp. 214-217 [ DOI: doi:10.1038/s41422-021-00585-8 Pubmed: 34754073 ]
- Atp-binding cassette sub-family d member 1 (79 kDa, Protein from Homo sapiens)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Oleoyl-coa-bound human abcd1 e630q (Complex from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6p2j
Q-score: 0.453
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature (2020) 581 pp. 333-338 [ DOI: doi:10.1038/s41586-020-2290-0 Pubmed: 32433614 ]
- Acat1 (Complex from Homo sapiens)
- Sterol o-acyltransferase 1 (69 kDa, Protein from Homo sapiens)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6p2p
Q-score: 0.462
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature (2020) 581 pp. 333-338 [ DOI: doi:10.1038/s41586-020-2290-0 Pubmed: 32433614 ]
- Acat1 (Complex from Homo sapiens)
- Sterol o-acyltransferase 1 (69 kDa, Protein from Homo sapiens)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6vp0
Q-score: 0.514
Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M
Nature (2020) 581 pp. 329-332 [ DOI: doi:10.1038/s41586-020-2280-2 Pubmed: 32433610 ]
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Diacylglycerol o-acyltransferase 1 (55 kDa, Protein from Homo sapiens)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Human diacylglycerol acyltransferase 1 in complex with oleoyl-coa (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of nevanimibe-bound human tetrameric ACAT1
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 6vum
Q-score: 0.45
Long T, Sun Y, Hassan A, Qi X, Li X
Nature (2020) 581 pp. 339-343 [ DOI: doi:10.1038/s41586-020-2295-8 Pubmed: 32433613 ]
- Acat1 (Cell from Homo sapiens)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Oleic acid (282 Da, Ligand)
- Sterol o-acyltransferase 1 (65 kDa, Protein from Homo sapiens)
- Coenzyme a (767 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Nevanimibe (421 Da, Ligand)
Cryo-EM structure of human diacylglycerol O-acyltransferase 1 complexed with acyl-CoA substrate
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6vz1
Q-score: 0.538
Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese Jr RV
Nature (2020) 581 pp. 323-328 [ DOI: doi:10.1038/s41586-020-2289-6 Pubmed: 32433611 ]
- Human diacylglycerol o-acyltransferase 1 (Complex from Homo sapiens)
- Diacylglycerol o-acyltransferase 1 (55 kDa, Protein from Homo sapiens)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)