Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"Imetit bound histamine h4 receptor in complex with Gq"

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EMD-33786

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Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex

Release date: Oct. 25, 2023
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7yfd
Q-score: 0.552

Im D, Kishikawa JI, Shiimura Y, Hisano H, Ito A, Fujita-Fujiharu Y, Sugita Y, Noda T, Kato T, Asada H, Iwata S

Nat Commun (2023) 14 pp. 6538-6538 [ Pubmed: 37863901 DOI: doi:10.1038/s41467-023-42260-z ]

Sample:

Imetit bound histamine h4 receptor in complex with gq (190 kDa, Complex from Homo sapiens)
Nb35 (14 kDa, Protein from Lama glama)
Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Lama glama)
Nb35 (Complex)
Scfv16 (27 kDa, Protein from Mus musculus)
Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Mus musculus)
Histamine h4 receptor (Complex from Homo sapiens)
Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
Engineered g-alpha-q (Complex from Homo sapiens)
Histamine h4 receptor (62 kDa, Protein from Homo sapiens)
2-(1~{h}-imidazol-5-yl)ethyl carbamimidothioate (170 Da, Ligand)
Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Engineered g-alpha-q (41 kDa, Protein from Homo sapiens)
Cholesterol (386 Da, Ligand)
Scfv16 (Complex from Homo sapiens)

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