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48-nm doublet microtubule from Tetrahymena thermophila strain MEC17
Yang SK, Kubo S, Black CS, Peri K, Dai D, Legal T, Valente-Paterno M, Gaertig J, Bui KH, Ori-McKenney KM, Cui Q
eLife (2024) 12 [ DOI: doi:10.7554/eLife.92219 ]
- Cfam166a (25 kDa, Protein from Tetrahymena thermophila)
- Oj2 (19 kDa, Protein from Tetrahymena thermophila)
- Cilia- and flagella-associated protein 52 (73 kDa, Protein from Tetrahymena thermophila)
- Tubulin beta chain (49 kDa, Protein from Tetrahymena thermophila)
- Sb1 (17 kDa, Protein from Tetrahymena thermophila)
- Rib27a (27 kDa, Protein from Tetrahymena thermophila)
- Cfap112b (32 kDa, Protein from Tetrahymena thermophila)
- Cilia- and flagella-associated protein 45 (59 kDa, Protein from Tetrahymena thermophila)
- Cfap161a (57 kDa, Protein from Tetrahymena thermophila)
- Ij34 (34 kDa, Protein from Tetrahymena thermophila)
- Rib26 (26 kDa, Protein from Tetrahymena thermophila)
- Parkin co-regulated protein pacrgb (28 kDa, Protein from Tetrahymena thermophila)
- Cfap210 (61 kDa, Protein from Tetrahymena thermophila)
- Cfap129 (31 kDa, Protein from Tetrahymena thermophila)
- Cfap115 (110 kDa, Protein from Tetrahymena thermophila)
- Flagellar flij protein (12 kDa, Protein from Tetrahymena thermophila)
- Cfap77a (28 kDa, Protein from Tetrahymena thermophila)
- Rib27b (26 kDa, Protein from Tetrahymena thermophila)
- Dna polymerase delta c4-type zinc-finger protein (31 kDa, Protein from Tetrahymena thermophila)
- Parkin co-regulated protein pacrga (36 kDa, Protein from Tetrahymena thermophila)
- Cfap112a (30 kDa, Protein from Tetrahymena thermophila)
- Cfap182a (20 kDa, Protein from Tetrahymena thermophila)
- Stpg1a (42 kDa, Protein from Tetrahymena thermophila)
- Cfam166c (25 kDa, Protein from Tetrahymena thermophila)
- Nucleoside diphosphate kinase (42 kDa, Protein from Tetrahymena thermophila)
- Rib43a protein (17 kDa, Protein from Tetrahymena thermophila)
- Flagellar microtugule protofilament ribbon protein (72 kDa, Protein from Tetrahymena thermophila)
- 48-nm repeat unit of microtubule doublet from tetrahymena thermophila strain mec17 (7 MDa, Cellular component from Tetrahymena thermophila)
- Rib22 (22 kDa, Protein from Tetrahymena thermophila)
- Nebulin (61 kDa, Protein from Tetrahymena thermophila)
- Cfap20 (22 kDa, Protein from Tetrahymena thermophila)
- Cfap143 (30 kDa, Protein from Tetrahymena thermophila)
- Protofilament ribbon protein (34 kDa, Protein from Tetrahymena thermophila)
- Rib35 (34 kDa, Protein from Tetrahymena thermophila)
- Magnesium ion (24 Da, Ligand)
- Cfap21a (48 kDa, Protein from Tetrahymena thermophila)
- Rib57 (57 kDa, Protein from Tetrahymena thermophila)
- Rib38 (38 kDa, Protein from Tetrahymena thermophila)
- Cfam166b (17 kDa, Protein from Tetrahymena thermophila)
- Tubulin alpha chain (49 kDa, Protein from Tetrahymena thermophila)
- Rib72b (60 kDa, Protein from Tetrahymena thermophila)
- Cilia- and flagella-associated protein 53 (60 kDa, Protein from Tetrahymena thermophila)
- Oj3 (19 kDa, Protein from Tetrahymena thermophila)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Stpg2 (33 kDa, Protein from Tetrahymena thermophila)
- Cfap107 (21 kDa, Protein from Tetrahymena thermophila)
- Cfap127 (55 kDa, Protein from Tetrahymena thermophila)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Cfap182b (11 kDa, Protein from Tetrahymena thermophila)
Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8qxj
Q-score: 0.574
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxy-5'-o-[(r)-hydroxy{[(r)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine (490 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Water (18 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of tetrameric human SAMHD1 State I - Tense
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8qxk
Q-score: 0.62
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8qxl
Q-score: 0.541
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- Triphosphate (257 Da, Ligand)
- 2'-deoxycytidine (227 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of tetrameric human SAMHD1 State III - Relaxed
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8qxm
Q-score: 0.573
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of tetrameric human SAMHD1 State IV - Depleted relaxed
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8qxn
Q-score: 0.459
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of tetrameric human SAMHD1 State V - Depleted relaxed
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8qxo
Q-score: 0.417
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
Mahalingan KK, Grotjahn DA, Li Y, Lander GC, Zehr EA, Roll-Mecak A
Nat Chem Biol (2024) [ Pubmed: 38658656 DOI: doi:10.1038/s41589-024-01599-0 ]
- Tubulin polyglutamylase ttll6 (Complex from Mus musculus)
- Tubulin alpha-1b chain (50 kDa, Protein from Homo sapiens)
- Tubulin polyglutamylase ttll6 (59 kDa, Protein from Mus musculus)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Ttll6 bound to unmodified human microtubules (300 kDa, Complex)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Tubulin alpha-1b chain, tubulin betai chain (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h6e
Q-score: 0.236
Zhang W, Zhang X, Zhan X, Bai R, Lei J, Yan C, Shi Y
Cell Res (2024) [ Pubmed: 38658629 DOI: doi:10.1038/s41422-024-00949-w ]
- U6 snrna-associated sm-like protein lsm3 (11 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- Isoform sm-b of small nuclear ribonucleoprotein-associated proteins b and b' (23 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- Thioredoxin-like protein 4a (16 kDa, Protein from Homo sapiens)
- U4/u6.u5 tri-snrnp-associated protein 2 (65 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna (45 kDa, RNA from Homo sapiens)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Probable atp-dependent rna helicase ddx23 (95 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm4 (15 kDa, Protein from Homo sapiens)
- Rna-binding protein 42 (50 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm5 (9 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm2 (10 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm8 (10 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm7 (11 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm6 (9 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- U4/u6.u5 tri-snrnp-associated protein 1 (90 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase prp4 homolog (117 kDa, Protein from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Nhp2-like protein 1 (14 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- U4/u6 small nuclear ribonucleoprotein prp3 (77 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- Exon-defined post pre-b spliceosome (2 MDa, Complex from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- U4/u6 small nuclear ribonucleoprotein prp31 (55 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- U4/u6.u5 small nuclear ribonucleoprotein 27 kda protein (18 kDa, Protein from Homo sapiens)
- U4 snrna (46 kDa, RNA from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- U4/u6 small nuclear ribonucleoprotein prp4 (58 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)
Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8h6j
Q-score: 0.224
Zhang W, Zhang X, Zhan X, Bai R, Lei J, Yan C, Shi Y
Cell Res (2024) [ Pubmed: 38658629 DOI: doi:10.1038/s41422-024-00949-w ]
- U6 snrna-associated sm-like protein lsm3 (11 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- Isoform sm-b of small nuclear ribonucleoprotein-associated proteins b and b' (23 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- Thioredoxin-like protein 4a (16 kDa, Protein from Homo sapiens)
- U4/u6.u5 tri-snrnp-associated protein 2 (65 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna (45 kDa, RNA from Homo sapiens)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Probable atp-dependent rna helicase ddx23 (95 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm4 (15 kDa, Protein from Homo sapiens)
- Rna-binding protein 42 (50 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm5 (9 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm2 (10 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm8 (10 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm7 (11 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm6 (9 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- U4 snrna (46 kDa, RNA from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- U4/u6.u5 tri-snrnp-associated protein 1 (90 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase prp4 homolog (117 kDa, Protein from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Nhp2-like protein 1 (14 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- U4/u6 small nuclear ribonucleoprotein prp3 (77 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- Exon-defined post pre-b spliceosome (2 MDa, Complex from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- U4/u6 small nuclear ribonucleoprotein prp31 (55 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- U4/u6.u5 small nuclear ribonucleoprotein 27 kda protein (18 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- U4/u6 small nuclear ribonucleoprotein prp4 (58 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)