Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"Etomidate" AND author_orcid:"0000-0001-5449-8850"

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EMD-17960

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Structure of GABAAR determined by cryoEM at 100 keV

Release date: Nov. 29, 2023
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8pvb
Q-score: 0.486

McMullan G, Naydenova K, Mihaylov D, Yamashita K, Peet MJ, Wilson H, Dickerson JL, Chen S, Cannone G, Lee Y, Hutchings KA, Gittins O, Sobhy MA, Wells T, El-Gomati MM, Dalby J, Meffert M, Schulze-Briese C, Henderson R, Russo CJ

PNAS (2023) 120 pp. e2312905120-e2312905120 [ Pubmed: 38011573 DOI: doi:10.1073/pnas.2312905120 ]

Sample:

Chloride ion (35 Da, Ligand)
Human gaba(a)r-beta3 homopentamer in complex with megabody-25 in lipid nanodisc (Complex from Homo sapiens)
Etomidate (244 Da, Ligand)
Histamine (111 Da, Ligand)
Gamma-aminobutyric acid receptor subunit beta-3 (45 kDa, Protein from Homo sapiens)
Hexadecane (226 Da, Ligand)
Megabody mb25 (56 kDa, Protein from Lama glama)
Decane (142 Da, Ligand)

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