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Structure of GABAAR determined by cryoEM at 100 keV
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8pvb
Q-score: 0.486
McMullan G, Naydenova K, Mihaylov D, Yamashita K, Peet MJ, Wilson H, Dickerson JL, Chen S, Cannone G, Lee Y, Hutchings KA, Gittins O, Sobhy MA, Wells T, El-Gomati MM, Dalby J, Meffert M, Schulze-Briese C, Henderson R, Russo CJ
PNAS (2023) 120 pp. e2312905120-e2312905120 [ DOI: doi:10.1073/pnas.2312905120 Pubmed: 38011573 ]
- Etomidate (244 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (45 kDa, Protein from Homo sapiens)
- Human gaba(a)r-beta3 homopentamer in complex with megabody-25 in lipid nanodisc (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Histamine (111 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Megabody mb25 (56 kDa, Protein from Lama glama)
- Decane (142 Da, Ligand)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8f6y
Q-score: 0.54
Goswami U, Rahman MM, Teng J, Hibbs RE
Nat Commun (2023) 14 pp. 3169-3169 [ Pubmed: 37264005 DOI: doi:10.1038/s41467-023-38827-5 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Etomidate (244 Da, Ligand)
- Acetylcholine receptor subunit alpha (49 kDa, Protein from Tetronarce californica)
- Cholesterol (386 Da, Ligand)
- Choline ion (104 Da, Ligand)
- Cryo-em structure of torpedo nicotinic acetylcholine receptor in complex with etomidate, desensitized-like state (Complex from Tetronarce californica)
- Acetylcholine receptor subunit delta (57 kDa, Protein from Tetronarce californica)
- Acetylcholine receptor subunit beta (53 kDa, Protein from Tetronarce californica)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Acetylcholine receptor subunit gamma (56 kDa, Protein from Tetronarce californica)
- Nonane (128 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6x3v
Q-score: 0.527
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Etomidate (244 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and etomidate (Complex from Homo sapiens)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)