Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research. We appreciate your responses prior to closing of the survey on Monday 17th June.
DNA initiation complex (configuration 1) of Xenopus laevis DNA polymerase alpha-primase
Resolution: 11.16 Å
EM Method: Single-particle
Fitted PDBs: 8v6g
Q-score: 0.051
Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF
Nat Struct Mol Biol (2024) 31 pp. 777-790 [ Pubmed: 38491139 DOI: doi:10.1038/s41594-024-01227-4 ]
- Polymerase alpha-primase with a dna initiation substrate (110 kDa, Complex)
- Zinc ion (65 Da, Ligand)
- Dna primase (49 kDa, Protein from Xenopus laevis)
- Iron/sulfur cluster (351 Da, Ligand)
- Rna primer (2 kDa, RNA from synthetic construct)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Polymerase alpha (Complex from Xenopus laevis)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Xenopus laevis)
- Dna polymerase alpha subunit b (67 kDa, Protein from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Dna template (15 kDa, DNA from synthetic construct)
- Dna initiation substrate (20 kDa, Complex from synthetic construct)
- Primase (Complex from Xenopus laevis)
- Dna primase large subunit (59 kDa, Protein from Xenopus laevis)
DNA initiation complex (configuration 2) of Xenopus laevis DNA polymerase alpha-primase
Resolution: 11.11 Å
EM Method: Single-particle
Fitted PDBs: 8v6h
Q-score: 0.018
Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF
Nat Struct Mol Biol (2024) 31 pp. 777-790 [ Pubmed: 38491139 DOI: doi:10.1038/s41594-024-01227-4 ]
- Polymerase alpha-primase with a dna initiation substrate (110 kDa, Complex)
- Zinc ion (65 Da, Ligand)
- Dna primase (49 kDa, Protein from Xenopus laevis)
- Iron/sulfur cluster (351 Da, Ligand)
- Rna primer (2 kDa, RNA from synthetic construct)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Polymerase alpha (Complex from Xenopus laevis)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Xenopus laevis)
- Dna polymerase alpha subunit b (67 kDa, Protein from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Dna template (15 kDa, DNA from synthetic construct)
- Dna initiation substrate (20 kDa, Complex from synthetic construct)
- Primase (Complex from Xenopus laevis)
- Dna primase large subunit (59 kDa, Protein from Xenopus laevis)
DNA elongation complex (configuration 1) of Xenopus laevis DNA polymerase alpha-primase
Resolution: 14.06 Å
EM Method: Single-particle
Fitted PDBs: 8v6i
Q-score: 0.027
Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF
Nat Struct Mol Biol (2024) 31 pp. 777-790 [ Pubmed: 38491139 DOI: doi:10.1038/s41594-024-01227-4 ]
- Zinc ion (65 Da, Ligand)
- Dna primase (49 kDa, Protein from Xenopus laevis)
- Iron/sulfur cluster (351 Da, Ligand)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Dna elongation substrate (20 kDa, Complex from synthetic construct)
- Polymerase alpha (Complex from Xenopus laevis)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Xenopus laevis)
- Dna polymerase alpha subunit b (67 kDa, Protein from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Dna template (15 kDa, DNA from synthetic construct)
- Rna-dna primer (6 kDa, Macromolecule from synthetic construct)
- Primase (Complex from Xenopus laevis)
- Dna primase large subunit (59 kDa, Protein from Xenopus laevis)
- Polymerase alpha-primase with a dna elongation substrate (110 kDa, Complex)
DNA elongation complex (configuration 2) of Xenopus laevis DNA polymerase alpha-primase
Resolution: 11.11 Å
EM Method: Single-particle
Fitted PDBs: 8v6j
Q-score: 0.029
Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF
Nat Struct Mol Biol (2024) 31 pp. 777-790 [ Pubmed: 38491139 DOI: doi:10.1038/s41594-024-01227-4 ]
- Zinc ion (65 Da, Ligand)
- Dna primase (49 kDa, Protein from Xenopus laevis)
- Iron/sulfur cluster (351 Da, Ligand)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Dna elongation substrate (20 kDa, Complex from synthetic construct)
- Polymerase alpha (Complex from Xenopus laevis)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Xenopus laevis)
- Dna polymerase alpha subunit b (67 kDa, Protein from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Dna template (15 kDa, DNA from synthetic construct)
- Rna-dna primer (6 kDa, Macromolecule from synthetic construct)
- Primase (Complex from Xenopus laevis)
- Dna primase large subunit (59 kDa, Protein from Xenopus laevis)
- Polymerase alpha-primase with a dna elongation substrate (110 kDa, Complex)
RNA priming complex of Human polymerase alpha-primase (Conformation 2)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ DOI: doi:10.1016/j.jmb.2023.168330 Pubmed: 37884206 ]
- Rna priming substrate - template (DNA from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Dna primase large subunit (Protein from Homo sapiens)
- Ternary complex of polymerase alpha-primase bound to an rna primed-template substrate. (200 kDa, Complex from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
- Rna priming substrate - primer (RNA from Homo sapiens)
Human Polymerase alpha-Primase, polymerase alpha catalytic domain deletion mutant (Conformation 1)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ DOI: doi:10.1016/j.jmb.2023.168330 Pubmed: 37884206 ]
- Polymerase alpha-primase, pol alpha catalytic domain deletion mutant (180 kDa, Complex from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Dna primase large subunit (Protein from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
Human Polymerase alpha-Primase, polymerase alpha catalytic domain deletion mutant (Conformation 2)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ DOI: doi:10.1016/j.jmb.2023.168330 Pubmed: 37884206 ]
- Polymerase alpha-primase, pol alpha catalytic domain deletion mutant (180 kDa, Complex from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Dna primase large subunit (Protein from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
RNA priming complex of Human Polymerase-Alpha-Primase (Conformation 1)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ DOI: doi:10.1016/j.jmb.2023.168330 Pubmed: 37884206 ]
- Rna priming substrate - template (DNA from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Dna primase large subunit (Protein from Homo sapiens)
- Ternary complex of polymerase alpha-primase bound to an rna primed-template substrate. (200 kDa, Complex from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
- Rna priming substrate - primer (RNA from Homo sapiens)
RNA priming complex of Human Polymerase alpha-primase (Conformation 3)
Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
J Mol Biol (2023) 435 pp. 168330-168330 [ DOI: doi:10.1016/j.jmb.2023.168330 Pubmed: 37884206 ]
- Rna priming substrate - template (DNA from Homo sapiens)
- Dna polymerase alpha catalytic subunit (Protein from Homo sapiens)
- Dna polymerase alpha subunit b (Protein from Homo sapiens)
- Dna primase large subunit (Protein from Homo sapiens)
- Ternary complex of polymerase alpha-primase bound to an rna primed-template substrate. (200 kDa, Complex from Homo sapiens)
- Dna primase small subunit (Protein from Homo sapiens)
- Rna priming substrate - primer (RNA from Homo sapiens)
Complete DNA termination subcomplex 1 of Xenopus laevis DNA polymerase alpha-primase
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8ucv
Q-score: 0.337
Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF
Nat Struct Mol Biol (2024) 31 pp. 777-790 [ Pubmed: 38491139 DOI: doi:10.1038/s41594-024-01227-4 ]
- Polymerase alpha (200 kDa, Complex from Xenopus laevis)
- Dna termination substrate (30 kDa, Complex from synthetic construct)
- Iron/sulfur cluster (351 Da, Ligand)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Xenopus laevis)
- Polymerase alpha-primase with a dna termination substrate (330 kDa, Complex)
- Magnesium ion (24 Da, Ligand)
- Dna template (18 kDa, DNA from synthetic construct)
- Primase (110 kDa, Complex from Xenopus laevis)
- Dna primase large subunit (59 kDa, Protein from Xenopus laevis)
- Rna-dna/dna primer (9 kDa, Macromolecule from synthetic construct)