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S. cerevisiae Chs1 in complex with polyoxin B
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8k3p
Q-score: 0.437
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ Pubmed: 37553334 DOI: doi:10.1038/s41467-023-40479-4 ]
- (2s)-2-[[(2s,3s,4s)-5-aminocarbonyloxy-2-azanyl-3,4-bis(oxidanyl)pentanoyl]amino]-2-[(2r,3s,4r,5r)-5-[5-(hydroxymethyl)-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]ethanoic acid (507 Da, Ligand)
- S. cerevisiae chs1 in complex with polyoxin b (Complex from Saccharomyces cerevisiae)
- Chitin synthase 1 (133 kDa, Protein from Saccharomyces cerevisiae S288C)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
S. cerevisiae Chs1 in apo state
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8k3q
Q-score: 0.59
S. cerevisiae Chs1 in complex with UDP
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8k3t
Q-score: 0.42
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ Pubmed: 37553334 DOI: doi:10.1038/s41467-023-40479-4 ]
- Uridine-5'-diphosphate (404 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- S. cerevisiae chs1 in complex with udp (Complex from Saccharomyces cerevisiae)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
S. cerevisiae Chs1 in complex with UDP-GlcNAc
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8k3v
Q-score: 0.53
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ Pubmed: 37553334 DOI: doi:10.1038/s41467-023-40479-4 ]
- S. cerevisiae chs1 in complex with udp-glcnac (Complex from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Uridine-diphosphate-n-acetylglucosamine (607 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
S. cerevisiae Chs1 in complex with UDP-GlcNAc and GlcNAc
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8k3w
Q-score: 0.496
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ Pubmed: 37553334 DOI: doi:10.1038/s41467-023-40479-4 ]
- S. cerevisiae chs1 in complex with udp-glcnac and glcnac (Complex from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Uridine-diphosphate-n-acetylglucosamine (607 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
S. cerevisiae Chs1 in complex with Nikkomycin Z
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8k3x
Q-score: 0.524
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ Pubmed: 37553334 DOI: doi:10.1038/s41467-023-40479-4 ]
- S. cerevisiae chs1 in complex with nikkomycin z (Complex from Saccharomyces cerevisiae)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
- (2s)-{[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name) (495 Da, Ligand)
S. cerevisiae Chs1 in complex with UDP and GlcNAc
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8k3u
Q-score: 0.445
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
Nat Commun (2023) 14 pp. 4776-4776 [ Pubmed: 37553334 DOI: doi:10.1038/s41467-023-40479-4 ]
- Uridine-5'-diphosphate (404 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- S. cerevisiae chs1 in complex with udp and glcnac (Complex from Saccharomyces cerevisiae)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
S. cerevisiae Chs1 in apo state incubated with GlcNAc
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8k3r
Q-score: 0.412
structure of a membrane-integrated glycosyltransferase with inhibitor
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7xs6
Q-score: 0.572
Wu YN, Zhang M, Yang YZ, Ding XY, Liu XT, Zhang MJ, Yu HJ
To Be Published
- Dodecane (170 Da, Ligand)
- Heptane (100 Da, Ligand)
- (2s)-{[(2s,3s,4s)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name) (495 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
- Membrane-integrated glycosyltransferase (Complex from Saccharomyces cerevisiae)
- (19r,22s)-25-amino-22-hydroxy-22-oxido-16-oxo-17,21,23-trioxa-22lambda~5~-phosphapentacosan-19-yl (9z)-hexadec-9-enoate (689 Da, Ligand)
structure of a membrane-integrated glycosyltransferase
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7xs7
Q-score: 0.547
Wu YN, Zhang M, Yang YZ, Ding XY, Liu XT, Zhang MJ, Yu HJ
To Be Published
- Dodecane (170 Da, Ligand)
- Heptane (100 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Chitin synthase 1 (130 kDa, Protein from Saccharomyces cerevisiae)
- Membrane-integrated glycosyltransferase (Complex from Saccharomyces cerevisiae)
- (19r,22s)-25-amino-22-hydroxy-22-oxido-16-oxo-17,21,23-trioxa-22lambda~5~-phosphapentacosan-19-yl (9z)-hexadec-9-enoate (689 Da, Ligand)