Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8ss2
Q-score: 0.438
Gangwar SP, Yen LY, Yelshanskaya MV, Korman A, Jones DR, Sobolevsky AI
Nat Struct Mol Biol (2023) 30 pp. 1481-1494 [ Pubmed: 37653241 DOI: doi:10.1038/s41594-023-01080-x ]
- Spermidine (145 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Glutamate receptor 2, voltage-dependent calcium channel gamma-5 subunit chimera (114 kDa, Protein from Rattus norvegicus)
- Protein cornichon homolog 2 (18 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Digitonin (1 kDa, Ligand)
- Glua2-tarp gamma5-cornichon-2 (Complex from Rattus norvegicus)
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8ss3
Q-score: 0.507
Gangwar SP, Yen LY, Yelshanskaya MV, Korman A, Jones DR, Sobolevsky AI
Nat Struct Mol Biol (2023) 30 pp. 1481-1494 [ Pubmed: 37653241 DOI: doi:10.1038/s41594-023-01080-x ]
- Spermidine (145 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Glutamate receptor 2, voltage-dependent calcium channel gamma-5 subunit chimera (114 kDa, Protein from Rattus norvegicus)
- Protein cornichon homolog 2 (18 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Digitonin (1 kDa, Ligand)
- Glua2-tarp gamma5-cornichon-2 (Complex from Rattus norvegicus)
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8ss6
Q-score: 0.475
Gangwar SP, Yen LY, Yelshanskaya MV, Korman A, Jones DR, Sobolevsky AI
Nat Struct Mol Biol (2023) 30 pp. 1481-1494 [ Pubmed: 37653241 DOI: doi:10.1038/s41594-023-01080-x ]
- 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile (349 Da, Ligand)
- Spermidine (145 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Glutamate receptor 2, voltage-dependent calcium channel gamma-5 subunit chimera (114 kDa, Protein from Rattus norvegicus)
- Protein cornichon homolog 2 (18 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Glua2-tarp gamma5-cornichon-2 (Complex from Rattus norvegicus)
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8ss7
Q-score: 0.544
Gangwar SP, Yen LY, Yelshanskaya MV, Korman A, Jones DR, Sobolevsky AI
Nat Struct Mol Biol (2023) 30 pp. 1481-1494 [ Pubmed: 37653241 DOI: doi:10.1038/s41594-023-01080-x ]
- 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile (349 Da, Ligand)
- Spermidine (145 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Glutamate receptor 2, voltage-dependent calcium channel gamma-5 subunit chimera (114 kDa, Protein from Rattus norvegicus)
- Protein cornichon homolog 2 (18 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Glua2-tarp gamma5-cornichon-2 (Complex from Rattus norvegicus)
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8ss8
Q-score: 0.53
Gangwar SP, Yen LY, Yelshanskaya MV, Korman A, Jones DR, Sobolevsky AI
Nat Struct Mol Biol (2023) 30 pp. 1481-1494 [ Pubmed: 37653241 DOI: doi:10.1038/s41594-023-01080-x ]
- 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile (349 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Glutamate receptor 2, voltage-dependent calcium channel gamma-5 subunit chimera (114 kDa, Protein from Rattus norvegicus)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Glua2-tarp gamma5 (Complex from Rattus norvegicus)
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8ss9
Q-score: 0.519
Gangwar SP, Yen LY, Yelshanskaya MV, Korman A, Jones DR, Sobolevsky AI
Nat Struct Mol Biol (2023) 30 pp. 1481-1494 [ Pubmed: 37653241 DOI: doi:10.1038/s41594-023-01080-x ]
- 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile (349 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Glutamate receptor 2, voltage-dependent calcium channel gamma-5 subunit chimera (114 kDa, Protein from Rattus norvegicus)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Glua2-tarp gamma5 (Complex from Rattus norvegicus)
Resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8c1q
Q-score: 0.54
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Water (18 Da, Ligand)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8c1r
Q-score: 0.55
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Homomeric glua2 f231a mutant ampa receptor in complex with tarp gamma 2 (Complex from Rattus)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- Water (18 Da, Ligand)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ayl
Q-score: 0.511
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ DOI: doi:10.1038/s41467-023-37259-5 Pubmed: 36966141 ]
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Resting state glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand jnj-61432059 (Complex from Rattus)
- Palmitic acid (256 Da, Ligand)
- 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one (443 Da, Ligand)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8aym
Q-score: 0.472
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ DOI: doi:10.1038/s41467-023-37259-5 Pubmed: 36966141 ]
- Glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand jnj-55511118 (Complex from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1h-benzimidazol-2-ol (328 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)