Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 7mjg
Q-score: 0.421
Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S
PLoS Biol (2021) 19 pp. e3001237-e3001237 [ Pubmed: 33914735 DOI: doi:10.1371/journal.pbio.3001237 ]
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 7mjh
Q-score: 0.394
Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S
PLoS Biol (2021) 19 pp. e3001237-e3001237 [ Pubmed: 33914735 DOI: doi:10.1371/journal.pbio.3001237 ]
- Vh ab8 (15 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 n501y mutant spike protein ectodomain bound to vh ab8 (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 7mji
Q-score: 0.516
Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S
PLoS Biol (2021) 19 pp. e3001237-e3001237 [ Pubmed: 33914735 DOI: doi:10.1371/journal.pbio.3001237 ]
- Vh ab8 (15 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 n501y mutant spike protein ectodomain bound to vh ab8 (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (class 1)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7mjj
Q-score: 0.316
Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S
PLoS Biol (2021) 19 pp. e3001237-e3001237 [ Pubmed: 33914735 DOI: doi:10.1371/journal.pbio.3001237 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab ab1 light chain (23 kDa, Protein from synthetic construct)
- Sars-cov-2 n501y mutant spike protein ectodomain bound to fab ab1 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab ab1 heavy chain (26 kDa, Protein from synthetic construct)
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (class 2)
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 7mjk
Q-score: 0.358
Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S
PLoS Biol (2021) 19 pp. e3001237-e3001237 [ Pubmed: 33914735 DOI: doi:10.1371/journal.pbio.3001237 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab ab1 light chain (23 kDa, Protein from synthetic construct)
- Sars-cov-2 n501y mutant spike protein ectodomain bound to fab ab1 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab ab1 heavy chain (26 kDa, Protein from synthetic construct)
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 7mjl
Q-score: 0.522
Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S
PLoS Biol (2021) 19 pp. e3001237-e3001237 [ Pubmed: 33914735 DOI: doi:10.1371/journal.pbio.3001237 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab ab1 light chain (23 kDa, Protein from synthetic construct)
- Sars-cov-2 n501y mutant spike protein ectodomain bound to fab ab1 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab ab1 heavy chain (26 kDa, Protein from synthetic construct)
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7mjm
Q-score: 0.299
Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S
PLoS Biol (2021) 19 pp. e3001237-e3001237 [ Pubmed: 33914735 DOI: doi:10.1371/journal.pbio.3001237 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (70 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 n501y mutant spike protein ectodomain bound to human ace2 ectodomain (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7mjn
Q-score: 0.443
Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S
PLoS Biol (2021) 19 pp. e3001237-e3001237 [ Pubmed: 33914735 DOI: doi:10.1371/journal.pbio.3001237 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (70 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 n501y mutant spike protein ectodomain bound to human ace2 ectodomain (Complex from Severe acute respiratory syndrome coronavirus 2)