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Cryo-EM structure of Gq-coupled MRGPRX1 bound with Compound-16
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hj5
Q-score: 0.534
Gan B, Yu L, Yang H, Jiao H, Pang B, Chen Y, Wang C, Lv R, Hu H, Cao Z, Ren R
PLoS Biol (2023) 21 pp. e3001975-e3001975 [ Pubmed: 37347749 DOI: doi:10.1371/journal.pbio.3001975 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gq coupled mrgprx1 bound with compound 16 (Complex from Homo sapiens)
- N-{2-[(1-aminoisoquinolin-6-yl)oxy]-4-methylphenyl}-2-methoxybenzene-1-sulfonamide (435 Da, Ligand)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Nb35 (17 kDa, Protein from Vicugna pacos)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member x1,lgbit (71 kDa, Protein from Homo sapiens)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 7vie
Q-score: 0.537
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ Pubmed: 35412894 DOI: doi:10.1073/pnas.2117716119 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- S1pr1/gi (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- S1pr1/gi complex with s1p (Complex from Homo sapiens)
- (2s,3r,4e)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (379 Da, Ligand)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7vif
Q-score: 0.553
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ Pubmed: 35412894 DOI: doi:10.1073/pnas.2117716119 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- S1pr1/gi (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- S1pr1/gi complex with fty720p (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (2~{s})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol (387 Da, Ligand)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7vig
Q-score: 0.563
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ Pubmed: 35412894 DOI: doi:10.1073/pnas.2117716119 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- S1pr1/gi (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid (409 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- S1pr1/gi complex with cbp-307 (Complex from Homo sapiens)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7vih
Q-score: 0.521
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ Pubmed: 35412894 DOI: doi:10.1073/pnas.2117716119 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- S1pr1/gi (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid (409 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- S1pr1/gi complex with cbp-307 (Complex from Homo sapiens)