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Cryo-EM structure of the human mitochondrial translocase TIM22 complex at 3.7 angstrom.
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7cgp
Q-score: 0.394
Qi L, Wang Q, Guan Z, Wu Y, Shen C, Hong S, Cao J, Zhang X, Yan C, Yin P
Cell Res (2020) [ DOI: doi:10.1038/s41422-020-00400-w Pubmed: 32901109 ]
- Mitochondrial import inner membrane translocase subunit tim10 (10 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (749 Da, Ligand)
- Mitochondrial import inner membrane translocase subunit tim22 (20 kDa, Protein from Homo sapiens)
- Mitochondrial import inner membrane translocase subunit tim10 b (11 kDa, Protein from Homo sapiens)
- Acylglycerol kinase, mitochondrial (47 kDa, Protein from Homo sapiens)
- Mitochondrial import inner membrane translocase subunit tim29 (29 kDa, Protein from Homo sapiens)
- Tim22 translocase (220 MDa, Complex from Homo sapiens)
- Mitochondrial import inner membrane translocase subunit tim9 (10 kDa, Protein from Homo sapiens)
cryoEM 3D reconstruction of IGF1R in complex with IGF1
Zhang X, Yu D, Sun J, Wu Y, Gong J, Li X, Liu L, Liu S, Liu J, Wu Y, Li D, Ma Y, Han X, Zhu Y, Wu Z, Wang Y, Ouyang Q, Wang T
Structure (2020) 28 pp. 555-561.e4 [ DOI: doi:10.1016/j.str.2020.03.007 Pubmed: 32275863 ]
- Igf1 receptor (Protein from Homo sapiens)
- Igf1r (300 MDa, Complex from Homo sapiens)
Structure of apo Lassa virus polymerase
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6klc
Q-score: 0.362
Peng R, Xu X, Jing J, Wang M, Peng Q, Liu S, Wu Y, Bao X, Wang P, Qi J, Gao GF, Shi Y
Nature (2020) 579 pp. 615-619 [ Pubmed: 32214249 DOI: doi:10.1038/s41586-020-2114-2 ]
- Manganese (ii) ion (54 Da, Ligand)
- Lassa virus polymerase (250 kDa, Complex from Lassa mammarenavirus)
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
Structure of apo Machupo virus polymerase
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 6kld
Q-score: 0.46
Peng R, Xu X, Jing J, Wang M, Peng Q, Liu S, Wu Y, Bao X, Wang P, Qi J, Gao GF, Shi Y
Nature (2020) 579 pp. 615-619 [ Pubmed: 32214249 DOI: doi:10.1038/s41586-020-2114-2 ]
- Rna-directed rna polymerase l (250 kDa, Protein from Machupo virus)
- Manganese (ii) ion (54 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Machupo virus polymerase (250 kDa, Complex from Machupo mammarenavirus)
Apo Machupo virus polymerase homodimer
Peng R, Xu X, Jing J, Wang M, Peng Q, Liu S, Wu Y, Bao X, Wang P, Qi J, Gao GF, Shi Y
Nature (2020) 579 pp. 615-619 [ Pubmed: 32214249 DOI: doi:10.1038/s41586-020-2114-2 ]
- Machupo virus polymerase (500 kDa, Complex from Machupo mammarenavirus)
- Machupo virus polymerase (Protein from Machupo mammarenavirus)
Monomeric structure of Machupo virus polymerase bound to vRNA promoter
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6kle
Q-score: 0.27
Peng R, Xu X, Jing J, Wang M, Peng Q, Liu S, Wu Y, Bao X, Wang P, Qi J, Gao GF, Shi Y
Nature (2020) 579 pp. 615-619 [ Pubmed: 32214249 DOI: doi:10.1038/s41586-020-2114-2 ]
- Rna (5'-r(*gp*cp*cp*up*ap*gp*gp*ap*up*cp*cp*ap*cp*up*gp*up*gp*cp*g)-3') (6 kDa, RNA from synthetic construct)
- Manganese (ii) ion (54 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (250 kDa, Protein from Machupo virus)
- Machupo virus polymerase bound to vrna promoter (270 kDa, Complex from Machupo mammarenavirus)
Dimeric structure of Machupo virus polymerase bound to vRNA promoter
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6klh
Q-score: 0.321
Peng R, Xu X, Jing J, Wang M, Peng Q, Liu S, Wu Y, Bao X, Wang P, Qi J, Gao GF, Shi Y
Nature (2020) 579 pp. 615-619 [ Pubmed: 32214249 DOI: doi:10.1038/s41586-020-2114-2 ]
- Rna (5'-r(*gp*cp*cp*up*ap*gp*gp*ap*up*cp*cp*ap*cp*up*gp*up*gp*cp*g)-3') (6 kDa, RNA from synthetic construct)
- Manganese (ii) ion (54 Da, Ligand)
- Machupo virus polymerase bound to vrna promoter (540 kDa, Complex from Machupo mammarenavirus)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (250 kDa, Protein from Machupo virus)
Cryo-EM structure of the full-length human IGF-1R in complex with insulin
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 6jk8
Q-score: 0.122
Zhang X, Yu D, Sun J, Wu Y, Gong J, Li X, Liu L, Liu S, Liu J, Wu Y, Li D, Ma Y, Han X, Zhu Y, Wu Z, Wang Y, Ouyang Q, Wang T
Structure (2020) 28 pp. 555-561.e4 [ DOI: doi:10.1016/j.str.2020.03.007 Pubmed: 32275863 ]
- Complex of full-length human type 1 insulin-like growth factor receptor with insulin (310 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor 1 receptor (154 kDa, Protein from Homo sapiens)
- Insulin (11 kDa, Protein from Homo sapiens)
cryo-EM structure of GPR52-miniGs-NB35
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 6li3
Q-score: 0.379
Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F
Nature (2020) 579 pp. 152-157 [ Pubmed: 32076264 DOI: doi:10.1038/s41586-020-2019-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpr52-gsbeta-gsgamma (Complex from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Gpr52-minigs-nb35 (Complex)
- Gsalpha-nb35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 52 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of a class A GPCR with G protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6kpf
Q-score: 0.556
Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Johnston CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ
Cell (2020) 180 pp. 655- [ DOI: doi:10.1016/j.cell.2020.01.008 Pubmed: 32004463 ]
- Cannabinoid receptor 2 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpcr-g protein complex (130 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 7-[(6ar,9r,10ar)-1-hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6h-benzo[c]chromen-3-yl]- 7-methyloctanenitrile (399 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)