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Langya henipavirus fusion protein in postfusion state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8tve
Q-score: 0.46
Langya henipavirus fusion protein in prefusion state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8tvf
Q-score: 0.59
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- Water (18 Da, Ligand)
- Langya henipavirus fusion protein in prefusion state (Complex from Langya virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Langya henipavirus fusion protein in prefusion state (58 kDa, Protein from Langya virus)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8tvg
Q-score: 0.509
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8tvh
Q-score: 0.498
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- Fusion glycoprotein (58 kDa, Protein from Langya virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4g5 light chain (11 kDa, Protein from Mus musculus)
- 4g5 heavy chain (13 kDa, Protein from Mus musculus)
- Langya henipavirus postfusion fusion protein in complex with 4g5 fab (Complex from Langya virus)
Langya henipavirus postfusion fusion protein in complex with 4G5 Fab (global refinement)
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- 4g5 fab light chain variable domain (Protein from Mus sp.)
- Langya henipavirus fusion protein in postfusion state (Protein from Langya virus)
- Langya henipavirus postfusion fusion protein in complex with 4g5 fab (Complex from Langya virus)
- 4g5 fab heavy chain variable domain (Protein from Mus sp.)
Ghanaian virus fusion glycoprotein (GhV F)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8tvb
Q-score: 0.56
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- Prefusion ghanian henipavirus f fused to the i53-50a trimer via an intervening 16 gs linker (Complex from Henipavirus ghanaense)
- Fusion glycoprotein f0,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (96 kDa, Protein from Thermotoga maritima MSB8)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Langya Virus G glycoprotein (LayV G) with stabilizing mutations
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tvi
Q-score: 0.552
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Langya virus attachment glycoprotein g (68 kDa, Protein from Langya virus)
- Zinc ion (65 Da, Ligand)
- Stabilized langya virus attachment glycoprotein layvg (Complex from Langya virus)
Langya Virus attachment (G) glycoprotein with K85L/L86K mutation
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8vwp
Q-score: 0.543
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- Langya virus attachment (g) protein (59 kDa, Protein from Langya virus)
- Langya virus attachment (g) protein (Complex from Langya virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8w20
Q-score: 0.295
Zhao Q, Bertolli S, Park YJ, Tan Y, Cutler KJ, Srinivas P, Asfahl KL, Fonesca-Garcia C, Gallagher LA, Li Y, Wang Y, Coleman-Derr D, DiMaio F, Zhang D, Peterson SB, Veesler D, Mougous JD
Nature (2024) 629 pp. 165-173 [ Pubmed: 38632398 DOI: doi:10.1038/s41586-024-07298-z ]
- Umb1 umbrella toxin particle (Complex from Streptomyces coelicolor A3(2))
- Secreted esterase (54 kDa, Protein from Streptomyces coelicolor A3(2))
- Intein c-terminal splicing domain-containing protein (142 kDa, Protein from Streptomyces coelicolor A3(2))
- Secreted protein (17 kDa, Protein from Streptomyces coelicolor A3(2))
Umb1 umbrella toxin particle (local refinement of UmbB1 bound ALF of UmbC1 and UmbA1)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8w22
Q-score: 0.386
Zhao Q, Bertolli S, Park YJ, Tan Y, Cutler KJ, Srinivas P, Asfahl KL, Fonesca-Garcia C, Gallagher LA, Li Y, Wang Y, Coleman-Derr D, DiMaio F, Zhang D, Peterson SB, Veesler D, Mougous JD
Nature (2024) 629 pp. 165-173 [ Pubmed: 38632398 DOI: doi:10.1038/s41586-024-07298-z ]
- Umb1 umbrella toxin particle (local refinement of umbb1 bound alf of umbc1 and umba1) (Complex from Streptomyces coelicolor A3(2))
- Secreted esterase (54 kDa, Protein from Streptomyces coelicolor A3(2))
- Intein c-terminal splicing domain-containing protein (142 kDa, Protein from Streptomyces coelicolor A3(2))
- Secreted protein (17 kDa, Protein from Streptomyces coelicolor A3(2))