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Cryo-EM structure of FFAR3 bound with valeric acid and AR420626
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8j20
Q-score: 0.393
Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J
Cell Res (2024) 34 pp. 323-326 [ DOI: doi:10.1038/s41422-023-00914-z Pubmed: 38191689 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 3 (35 kDa, Protein from Homo sapiens)
- Pentanoic acid (102 Da, Ligand)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (4r)-n-[2,5-bis(chloranyl)phenyl]-4-(furan-2-yl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1h-quinoline-3-carboxamide (417 Da, Ligand)
- The ffar3 complex bound with valeric acid (Complex from Homo sapiens)
Cryo-EM structure of FFAR3 complex bound with butyrate acid
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8j21
Q-score: 0.389
Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J
Cell Res (2024) 34 pp. 323-326 [ DOI: doi:10.1038/s41422-023-00914-z Pubmed: 38191689 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 3 (35 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Butanoic acid (88 Da, Ligand)
- The ffar3 complex bound with butyrate acid (Complex from Homo sapiens)
Cryo-EM structure of FFAR2 complex bound with TUG-1375
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8j22
Q-score: 0.463
Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J
Cell Res (2024) 34 pp. 323-326 [ DOI: doi:10.1038/s41422-023-00914-z Pubmed: 38191689 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 2 (35 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Ffar2 complex bound with tug-1375 (Complex from Homo sapiens)
- (2r,4r)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid (442 Da, Ligand)
Cryo-EM structure of FFAR2 complex bound with acetic acid
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8j24
Q-score: 0.545
Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J
Cell Res (2024) 34 pp. 323-326 [ DOI: doi:10.1038/s41422-023-00914-z Pubmed: 38191689 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 2 (35 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 2 complex (Complex from Homo sapiens)
- Acetate ion (59 Da, Ligand)
- Scgv16 (31 kDa, Protein from Homo sapiens)
H2HA A/Japan/305/1957 complexed with mouse polyclonal Fab - wk 12, reoriented immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
H2HA A/Japan/305/1957 complexed with mouse polyclonal Fab - wk 12, control immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
- Polyclonal fab (Complex from Mus musculus)
- Influenza a virus (a/japan/305/1957(h2n2)) (Complex from Influenza A virus (A/Japan/305/1957(H2N2)))
- H2ha a/japan/305/1957 (Protein)
- H2ha a/japan/305/1957 immune complex with mouse polyclonal fab - week 12, control immunogen group (Complex)
H7N9 A/Shanghai/2/2013 complexed with mouse polyclonal Fab - wk 12, control immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
H3N2 A/Victoria/3/1975 complexed with mouse polyclonal Fab - wk 7, control immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
- H3n2 a/victoria/3/1975 immune complex with mouse polyclonal fab - week 7, control immunogen group (Complex)
- Polyclonal fab (Complex from Mus musculus)
- H3n2 a/victoria/3/1975 (Protein from Influenza A virus (A/Victoria/3/1975(H3N2)))
- H3n2 a/victoria/3/1975 (Complex from Influenza A virus (A/Victoria/3/1975(H3N2)))
H3N2 A/Victoria/3/1975 complexed with mouse polyclonal Fab - wk 7, reoH2HA immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
H7N9 A/Shanghai/2/2013 complexed with mouse polyclonal Fab - wk 7, reoriented immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]