Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7d7m
Q-score: 0.47
Nojima S, Fujita Y, Kimura KT, Nomura N, Suno R, Morimoto K, Yamamoto M, Noda T, Iwata S, Shigematsu H, Kobayashi T
Structure (2021) 29 pp. 252-260.e6 [ Pubmed: 33264604 DOI: doi:10.1016/j.str.2020.11.007 ]
- Prostaglandin e2 receptor ep4 subtype,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
- Pge2-ep4-gs-gbeta1-ggamma2-nb35 complex (120 kDa, Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Nanobody nb35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype,prostaglandin e2 receptor ep4 subtype (36 kDa, Protein from Homo sapiens)
- Nanobody nb35 (14 kDa, Protein from Lama glama)
Cryo-EM reconstruction of TLR7/Cpd-3 (SM-394830) complex in closed form
Tojo S, Zhang Z, Matsui H, Tahara M, Ikeguchi M, Kochi M, Kamada M, Shigematsu H, Tsutsumi A, Adachi N, Shibata T, Yamamoto M, Kikkawa M, Senda T, Isobe Y, Ohto U, Shimizu T
Nat Commun (2020) 11 pp. 5204-5204 [ DOI: doi:10.1038/s41467-020-19025-z Pubmed: 33060576 ]
- Tlr7/cpd-3 (sm-394830) complex (200 kDa, Complex from Macaca mulatta)
Cryo-EM reconstruction of TLR7/Cpd-6 (DSR-139293) complex in closed form
Tojo S, Zhang Z, Matsui H, Tahara M, Ikeguchi M, Kochi M, Kamada M, Shigematsu H, Tsutsumi A, Adachi N, Shibata T, Yamamoto M, Kikkawa M, Senda T, Isobe Y, Ohto U, Shimizu T
Nat Commun (2020) 11 pp. 5204-5204 [ DOI: doi:10.1038/s41467-020-19025-z Pubmed: 33060576 ]
- Tlr7/cpd-6 (dsr-139293) complex (200 kDa, Complex from Macaca mulatta)
Cryo-EM reconstruction of TLR7/Cpd-6 (DSR-139293) complex in open form
Tojo S, Zhang Z, Matsui H, Tahara M, Ikeguchi M, Kochi M, Kamada M, Shigematsu H, Tsutsumi A, Adachi N, Shibata T, Yamamoto M, Kikkawa M, Senda T, Isobe Y, Ohto U, Shimizu T
Nat Commun (2020) 11 pp. 5204-5204 [ DOI: doi:10.1038/s41467-020-19025-z Pubmed: 33060576 ]
- Tlr7/cpd-6 (dsr-139293) complex (200 kDa, Complex from Macaca mulatta)
Cryo-EM reconstruction of TLR7/Cpd-7 (DSR-139970) complex in open form
Tojo S, Zhang Z, Matsui H, Tahara M, Ikeguchi M, Kochi M, Kamada M, Shigematsu H, Tsutsumi A, Adachi N, Shibata T, Yamamoto M, Kikkawa M, Senda T, Isobe Y, Ohto U, Shimizu T
Nat Commun (2020) 11 pp. 5204-5204 [ DOI: doi:10.1038/s41467-020-19025-z Pubmed: 33060576 ]
- Tlr7/cpd-7 (dsr-139970) complex (200 kDa, Complex from Macaca mulatta)
Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6lw1
Q-score: 0.54
Tojo S, Zhang Z, Matsui H, Tahara M, Ikeguchi M, Kochi M, Kamada M, Shigematsu H, Tsutsumi A, Adachi N, Shibata T, Yamamoto M, Kikkawa M, Senda T, Isobe Y, Ohto U, Shimizu T
Nat Commun (2020) 11 pp. 5204-5204 [ DOI: doi:10.1038/s41467-020-19025-z Pubmed: 33060576 ]