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Structure of Apo CXCR4/Gi complex
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8u4n
Q-score: 0.56
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Apo cxcr4/gi complex (Complex from Homo sapiens)
Structure of CXCL12-bound CXCR4/Gi complex
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8u4o
Q-score: 0.489
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Cxcl12-bound cxcr4/gi complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Stromal cell-derived factor 1 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
Structure of AMD3100-bound CXCR4/Gi complex
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8u4p
Q-score: 0.532
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Amd3100-bound cxcr4/gi complex (Complex from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Plerixafor (502 Da, Ligand)
Structure of REGN7663 Fab-bound CXCR4/Gi complex
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8u4q
Q-score: 0.487
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Regn7663 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Regn7663 fab light chain (24 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Regn7663 fab-bound cxcr4/gi complex (Complex from Homo sapiens)
Structure of REGN7663-Fab bound CXCR4
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8u4r
Q-score: 0.554
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Regn7663 fab light chain (24 kDa, Protein from Homo sapiens)
- Regn7663 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Regn7663 fab-bound cxcr4 (Complex from Homo sapiens)
Structure of trimeric CXCR4 in complex with REGN7663 Fab
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8u4s
Q-score: 0.49
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- (2r)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9z)-octadec-9-enoate (674 Da, Ligand)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Regn7663 fab light chain (24 kDa, Protein from Homo sapiens)
- Regn7663 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Trimeric cxcr4 in complex with regn7663 fab (Complex from Homo sapiens)
Structure of tetrameric CXCR4 in complex with REGN7663 Fab
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8u4t
Q-score: 0.51
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- (2r)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9z)-octadec-9-enoate (674 Da, Ligand)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Tetrameric cxcr4 in complex with regn7663 fab (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Regn7663 fab light chain (24 kDa, Protein from Homo sapiens)
- Regn7663 fab heavy chain (25 kDa, Protein from Homo sapiens)
CryoEM structure of HLA-A2 MAGEA4 (230-239) in complex with REGN6972 Fab and 2M2 Fab
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8fja
Q-score: 0.531
To Be Published
- Mhc class i antigen, beta-2-microglobulin (Complex from Homo sapiens)
- Regn6972 fab light chain, regn6972 fab heavy chain (Complex from Homo sapiens)
- Melanoma-associated antigen 4 peptide (Complex)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
- Melanoma-associated antigen 4 peptide (1 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- Regn6972 fab light chain (23 kDa, Protein from Homo sapiens)
- Regn6972 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Hla-a2 magea4 (230-239) in complex with regn6972 fab and 2m2 fab (Complex)
CryoEM structure of HLA-A2 MAGEA4 (286-294) in complex with H2aM31345N Fab and 2M2 Fab
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8fjb
Q-score: 0.574
To Be Published
- Mhc class i antigen, beta-2-microglobulin (Complex from Homo sapiens)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
- Melanoma-associated antigen 4 peptide (Complex)
- Melanoma-associated antigen 4 peptide (1 kDa, Protein from Homo sapiens)
- H2am31345n fab heavy chain, h2am31345n fab light chain (Complex from Homo sapiens)
- H2am31345n fab heavy chain (23 kDa, Protein from Homo sapiens)
- Hla-a2 magea4 (286-294) complex with h2am31345n fab and 2m2 fab (Complex)
- H2am31345n fab light chain (23 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
CryoEM structure of PN45545 TCR-CD3 complex
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8es7
Q-score: 0.531
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ DOI: doi:10.1038/s41467-023-37532-7 Pubmed: 37100770 ]
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- Pn45545 tcr alpha chain (30 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45545 tcr-cd3 complex (Complex from Homo sapiens)
- Pn45545 tcr beta chain (35 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)