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EMD-19576

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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN

Release date: May 15, 2024
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8rxh
Q-score: 0.603

Rajan KS, Aryal S, Hiregange DG, Bashan A, Madmoni H, Olami M, Doniger T, Cohen-Chalamish S, Pescher P, Taoka M, Nobe Y, Fedorenko A, Bose T, Zimermann E, Prina E, Aharon-Hefetz N, Pilpel Y, Isobe T, Unger R, Spath GF, Yonath A, Michaeli S

Cell Rep (2024) 43 pp. 114203-114203 [ Pubmed: 38722744 DOI: doi:10.1016/j.celrep.2024.114203 ]

Sample:

Ubiquitin-60s ribosomal protein l40 (17 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s25 (13 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l37a (10 kDa, Protein from Leishmania major strain Friedlin)
Sr4_chain_5 (43 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s15 (17 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s4 (30 kDa, Protein from Leishmania major strain Friedlin)
Ssu_rrna_chain_s1 (710 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein l14 (19 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l28 (16 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s19-like protein (18 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l21 (18 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s3a (30 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s27-1 (9 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l9 (21 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l44 (12 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l10 (24 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l32 (15 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l27 (15 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s9 (22 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l13 (24 kDa, Protein from Leishmania major strain Friedlin)
A-site_trna_chain_s2 (24 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l34 (19 kDa, Protein from Leishmania major strain Friedlin)
Sr2_chain_4 (59 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s23 (15 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l36 (11 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l23 (14 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s24 (15 kDa, Protein from Leishmania major strain Friedlin)
Lsub_rrna_chain_2 (492 kDa, RNA from Leishmania major strain Friedlin)
Sodium ion (22 Da, Ligand)
E-site_trna_chain_s4 (24 kDa, RNA from Leishmania major strain Friedlin)
Putative ribosomal protein l3 (47 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l19 (28 kDa, Protein from Leishmania major strain Friedlin)
Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l5 (34 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l2 (28 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l35 (15 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s14 (15 kDa, Protein from Leishmania major strain Friedlin)
Zinc ion (65 Da, Ligand)
Putative 40s ribosomal protein s10 (18 kDa, Protein from Leishmania major strain Friedlin)
5s_rrna_chain_8 (39 kDa, RNA from Leishmania major strain Friedlin)
Putative ribosomal protein l24 (14 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s6 (28 kDa, Protein from Leishmania major strain Friedlin)
(2s)-2-[2-[4-[[(2r,3s,4s)-3-acetyloxy-4-oxidanyl-pyrrolidin-2-yl]methyl]phenoxy]ethanoylamino]-6-azanyl-hexanoic acid (437 Da, Ligand)
40s ribosomal protein s30 (7 kDa, Protein from Leishmania major strain Friedlin)
Lsua_rrna_chain_1 (577 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s16 (16 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l7 (28 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s17 (16 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s26 (12 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein sa (27 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s13 (17 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l41 (4 kDa, Protein from Leishmania major strain Friedlin)
Water (18 Da, Ligand)
Putative 40s ribosomal protein s21 (17 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l39 (6 kDa, Protein from Leishmania major strain Friedlin)
Guanine nucleotide-binding protein subunit beta-like protein (34 kDa, Protein from Leishmania major strain Friedlin)
Ribosomal protein s17 family protein (20 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s5 (21 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s33 (9 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein s29 (6 kDa, Protein from Leishmania major strain Friedlin)
Ribosomal protein l37 (9 kDa, Protein from Leishmania major strain Friedlin)
Ribosomal protein l15 (24 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l18 (22 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l29 (8 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l13a (25 kDa, Protein from Leishmania major strain Friedlin)
Magnesium ion (24 Da, Ligand)
40s ribosomal protein s7 (23 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l23a (16 kDa, Protein from Leishmania major strain Friedlin)
Putative rna binding protein (25 kDa, Protein from Leishmania major strain Friedlin)
Sr6_chain_6 (23 kDa, RNA from Leishmania major strain Friedlin)
60s ribosomal protein l30 (11 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s2 (28 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s15a (14 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l35a (16 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal subunit protein l31 (21 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s8 (24 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l7a (29 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l17 (19 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein s20 (13 kDa, Protein from Leishmania major strain Friedlin)
Mrna_chain_s5 (4 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l26 (16 kDa, Protein from Leishmania major strain Friedlin)
Sr1_chain_3 (69 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s18 (17 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l6 (21 kDa, Protein from Leishmania major strain Friedlin)
5.8s_rrna_chain_7 (54 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l27a/l29 (16 kDa, Protein from Leishmania major strain Friedlin)
Cryo-em structure of leishmania major 80s ribosome with a/p/e-site trna and mrna (Complex from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l22 (15 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l18a (20 kDa, Protein from Leishmania major strain Friedlin)
P-site_trna_chain_s3 (24 kDa, RNA from Leishmania major strain Friedlin)
40s ribosomal protein s12 (15 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l1a (41 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l38 (9 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l11 (21 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s3 (24 kDa, Protein from Leishmania major strain Friedlin)
Potassium ion (39 Da, Ligand)

[Show more]

EMD-19582

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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN

Release date: May 15, 2024
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8rxx
Q-score: 0.601

Cell Rep (2024) 43 pp. 114203-114203 [ Pubmed: 38722744 DOI: doi:10.1016/j.celrep.2024.114203 ]

Sample:

Ubiquitin-60s ribosomal protein l40 (17 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s25 (13 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l37a (10 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s15 (17 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s4 (30 kDa, Protein from Leishmania major strain Friedlin)
Lsub_rrna_chain_2 (492 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein l14 (19 kDa, Protein from Leishmania major strain Friedlin)
5s_rrna_chain_8 (39 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l28 (16 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s19-like protein (18 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l21 (18 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s3a (30 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s27-1 (9 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l9 (21 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l44 (12 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l10 (24 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l32 (15 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l27 (15 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s9 (22 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l13 (24 kDa, Protein from Leishmania major strain Friedlin)
A-site_trna_chain_s2 (24 kDa, RNA from Leishmania major strain Friedlin)
Sr4_chain_5 (43 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l34 (19 kDa, Protein from Leishmania major strain Friedlin)
Sr2_chain_4 (59 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s23 (15 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l36 (11 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l23 (14 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s24 (15 kDa, Protein from Leishmania major strain Friedlin)
Sodium ion (22 Da, Ligand)
E-site_trna_chain_s4 (24 kDa, RNA from Leishmania major strain Friedlin)
Putative ribosomal protein l3 (47 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l19 (28 kDa, Protein from Leishmania major strain Friedlin)
Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Leishmania major strain Friedlin)
Lsua_rrna_chain_1 (577 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l5 (34 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l2 (28 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l35 (15 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s14 (15 kDa, Protein from Leishmania major strain Friedlin)
Zinc ion (65 Da, Ligand)
Putative 40s ribosomal protein s10 (18 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l24 (14 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s6 (28 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s30 (7 kDa, Protein from Leishmania major strain Friedlin)
Ssu_rrna_chain_s1 (710 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s16 (16 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l7 (28 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s17 (16 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s26 (12 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein sa (27 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s13 (17 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l41 (4 kDa, Protein from Leishmania major strain Friedlin)
Water (18 Da, Ligand)
Putative 40s ribosomal protein s21 (17 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l39 (6 kDa, Protein from Leishmania major strain Friedlin)
Guanine nucleotide-binding protein subunit beta-like protein (34 kDa, Protein from Leishmania major strain Friedlin)
Ribosomal protein s17 family protein (20 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s5 (21 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s33 (9 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein s29 (6 kDa, Protein from Leishmania major strain Friedlin)
Ribosomal protein l37 (9 kDa, Protein from Leishmania major strain Friedlin)
Ribosomal protein l15 (24 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l18 (22 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l29 (8 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l13a (25 kDa, Protein from Leishmania major strain Friedlin)
Magnesium ion (24 Da, Ligand)
40s ribosomal protein s7 (23 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l23a (16 kDa, Protein from Leishmania major strain Friedlin)
Putative rna binding protein (25 kDa, Protein from Leishmania major strain Friedlin)
Sr6_chain_6 (23 kDa, RNA from Leishmania major strain Friedlin)
60s ribosomal protein l30 (11 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s2 (28 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s15a (14 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l35a (16 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal subunit protein l31 (21 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s8 (24 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l7a (29 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l17 (19 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein s20 (13 kDa, Protein from Leishmania major strain Friedlin)
Mrna_chain_s5 (4 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l26 (16 kDa, Protein from Leishmania major strain Friedlin)
Sr1_chain_3 (69 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s18 (17 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l6 (21 kDa, Protein from Leishmania major strain Friedlin)
5.8s_rrna_chain_7 (54 kDa, RNA from Leishmania major strain Friedlin)
80s ribosome with a/p/e-site trna and mrna (Complex from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l27a/l29 (16 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l22 (15 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l18a (20 kDa, Protein from Leishmania major strain Friedlin)
P-site_trna_chain_s3 (24 kDa, RNA from Leishmania major strain Friedlin)
40s ribosomal protein s12 (15 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l1a (41 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l38 (9 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l11 (21 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s3 (24 kDa, Protein from Leishmania major strain Friedlin)
Potassium ion (39 Da, Ligand)

[Show more]

EMD-17216

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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN

Release date: May 8, 2024
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8ovj
Q-score: 0.63

Cell Rep (2024) 43 pp. 114203-114203 [ Pubmed: 38722744 DOI: doi:10.1016/j.celrep.2024.114203 ]

Sample:

Sr2_chain_4 (59 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s11 (20 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s25 (13 kDa, Protein from Leishmania major strain Friedlin)
Lsub_rrna_chain_2 (492 kDa, RNA from Leishmania major strain Friedlin)
60s ribosomal protein l37a (10 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s15 (17 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s4 (30 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein l14 (19 kDa, Protein from Leishmania major strain Friedlin)
5s_rrna_chain_8 (39 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l28 (16 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s19-like protein (18 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l21 (18 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s3a (30 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s27-1 (9 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l9 (21 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l44 (12 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l10 (24 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l32 (15 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l27 (15 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s9 (22 kDa, Protein from Leishmania major strain Friedlin)
Ssu_rrna_chain_s1 (710 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l13 (24 kDa, Protein from Leishmania major strain Friedlin)
Sr4_chain_5 (43 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l34 (19 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s23 (15 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l36 (11 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l23 (14 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s24 (15 kDa, Protein from Leishmania major strain Friedlin)
Sodium ion (22 Da, Ligand)
Putative ribosomal protein l3 (47 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l19 (28 kDa, Protein from Leishmania major strain Friedlin)
Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l5 (34 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l2 (28 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l35 (15 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s14 (15 kDa, Protein from Leishmania major strain Friedlin)
Zinc ion (65 Da, Ligand)
Putative 40s ribosomal protein s10 (18 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l24 (14 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s6 (28 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s30 (7 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s16 (16 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s17 (16 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l7 (28 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s26 (12 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein sa (27 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s13 (17 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l41 (4 kDa, Protein from Leishmania major strain Friedlin)
Water (18 Da, Ligand)
E-site_trna_chain_s4 (6 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s21 (17 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l39 (6 kDa, Protein from Leishmania major strain Friedlin)
Guanine nucleotide-binding protein subunit beta-like protein (34 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s5 (21 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s33 (9 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein s29 (6 kDa, Protein from Leishmania major strain Friedlin)
Ribosomal protein l37 (9 kDa, Protein from Leishmania major strain Friedlin)
Ribosomal protein l15 (24 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l18 (22 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l29 (8 kDa, Protein from Leishmania major strain Friedlin)
Lsua_rrna_chain_1 (577 kDa, RNA from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l13a (25 kDa, Protein from Leishmania major strain Friedlin)
Magnesium ion (24 Da, Ligand)
40s ribosomal protein s7 (23 kDa, Protein from Leishmania major strain Friedlin)
Putative rna binding protein (25 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l23a (16 kDa, Protein from Leishmania major strain Friedlin)
5.8s_rrna_chain_7 (54 kDa, RNA from Leishmania major strain Friedlin)
Sr6_chain_6 (23 kDa, RNA from Leishmania major strain Friedlin)
60s ribosomal protein l30 (11 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s2 (28 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s15a (14 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l35a (16 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal subunit protein l31 (21 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s8 (24 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l7a (29 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l17 (19 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein s20 (13 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l26 (16 kDa, Protein from Leishmania major strain Friedlin)
Sr1_chain_3 (69 kDa, RNA from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s18 (17 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l6 (21 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l27a/l29 (16 kDa, Protein from Leishmania major strain Friedlin)
Putative 60s ribosomal protein l22 (15 kDa, Protein from Leishmania major strain Friedlin)
80s ribosome from leishmania major (Complex from Leishmania major strain Friedlin)
60s ribosomal protein l18a (20 kDa, Protein from Leishmania major strain Friedlin)
40s ribosomal protein s12 (15 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l1a (41 kDa, Protein from Leishmania major strain Friedlin)
Putative ribosomal protein l38 (9 kDa, Protein from Leishmania major strain Friedlin)
60s ribosomal protein l11 (21 kDa, Protein from Leishmania major strain Friedlin)
Putative 40s ribosomal protein s3 (24 kDa, Protein from Leishmania major strain Friedlin)
Potassium ion (39 Da, Ligand)

[Show more]

EMD-17363

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Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane in post-translocational state

Release date: May 1, 2024
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 8p2f
Q-score: 0.597

Gonzalez-Lopez A, Larsson D, Nelson B, Hergenrother PJ, Selmer M

To Be Published

Sample:

Water (18 Da, Ligand)
Trna (24 kDa, RNA from Escherichia coli)
30s ribosomal protein s7 (17 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s6 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s12 (15 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l6 (19 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s18 (9 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
1,4-diaminobutane (88 Da, Ligand)
Potassium ion (39 Da, Ligand)
30s ribosomal protein s9 (14 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l21 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l17 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s5 (17 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Elongation factor g (76 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l16 (16 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Magnesium ion (24 Da, Ligand)
30s ribosomal protein s8 (14 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l31 type b (9 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l4 (22 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s2 (29 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s15 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l35 (7 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
5s ribosomal rna (36 kDa, RNA from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l19 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l5 (20 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s10 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s11 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l15 (15 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l20 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s17 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Spermidine (145 Da, Ligand)
50s ribosomal protein l32 (6 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Staphylococcus aureus 70s ribosome with elongation factor g and fusidic acid cyclopentane (2 MDa, Complex from Staphylococcus aureus subsp. aureus NCTC 8325)
2-[(3~{r},4~{s},5~{s},8~{s},9~{s},10~{s},11~{r},13~{s},14~{s},16~{s})-16-acetyloxy-4,8,10,14-tetramethyl-3,11-bis(oxidanyl)-1,2,3,4,5,6,7,9,11,12,13,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5-cyclopentyl-pentanoic acid (546 Da, Ligand)
50s ribosomal protein l3 (23 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l22 (12 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l36 (4 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
23s ribosomal rna (946 kDa, RNA from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s16 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s14 type z (7 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l2 (30 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s3 (24 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l23 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l28 (6 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s20 (9 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Zinc ion (65 Da, Ligand)
50s ribosomal protein l29 (8 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l14 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l25 (23 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s13 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l33 1 (5 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s4 (23 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Mrna (7 kDa, RNA from Escherichia coli)
50s ribosomal protein l34 (5 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l13 (16 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l30 (6 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l27 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s19 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
16s ribosomal rna (503 kDa, RNA from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l24 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Guanosine-5'-diphosphate (443 Da, Ligand)
50s ribosomal protein l18 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)

[Show more]

EMD-17364

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Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane with a tRNA in pe/E chimeric hybrid state

Release date: May 1, 2024
Resolution: 2.02 Å
EM Method: Single-particle
Fitted PDBs: 8p2g
Q-score: 0.68

Gonzalez-Lopez A, Larsson D, Nelson B, Hergenrother PJ, Selmer M

To Be Published

Sample:

Water (18 Da, Ligand)
Trna (24 kDa, RNA from Escherichia coli)
30s ribosomal protein s7 (17 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s6 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s12 (15 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l6 (19 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s18 (9 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
1,4-diaminobutane (88 Da, Ligand)
30s ribosomal protein s9 (14 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l21 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l17 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s5 (17 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Elongation factor g (76 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l16 (16 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Magnesium ion (24 Da, Ligand)
30s ribosomal protein s8 (14 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l31 type b (9 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l4 (22 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s2 (29 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s15 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l35 (7 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
5s ribosomal rna (36 kDa, RNA from Staphylococcus aureus subsp. aureus NCTC 8325)
Large ribosomal subunit protein bl33a (5 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l19 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l5 (20 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s11 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l15 (15 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l20 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s17 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Spermidine (145 Da, Ligand)
Large ribosomal subunit protein bl32 (6 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Staphylococcus aureus 70s ribosome with elongation factor g and fusidic acid cyclopentane (2 MDa, Complex from Staphylococcus aureus subsp. aureus NCTC 8325)
2-[(3~{r},4~{s},5~{s},8~{s},9~{s},10~{s},11~{r},13~{s},14~{s},16~{s})-16-acetyloxy-4,8,10,14-tetramethyl-3,11-bis(oxidanyl)-1,2,3,4,5,6,7,9,11,12,13,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5-cyclopentyl-pentanoic acid (546 Da, Ligand)
50s ribosomal protein l3 (23 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l22 (12 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l36 (4 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
23s ribosomal rna (946 kDa, RNA from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s16 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Small ribosomal subunit protein us10 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s14 type z (7 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l2 (30 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s3 (24 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l23 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l28 (6 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s20 (9 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Zinc ion (65 Da, Ligand)
50s ribosomal protein l29 (8 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l14 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l25 (23 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s13 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s4 (23 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Mrna (7 kDa, RNA from Escherichia coli)
50s ribosomal protein l34 (5 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l13 (16 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l30 (6 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l27 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s19 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
16s ribosomal rna (503 kDa, RNA from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l24 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Guanosine-5'-diphosphate (443 Da, Ligand)
50s ribosomal protein l18 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)

[Show more]

EMD-17365

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Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid with a tRNA in pe/E chimeric state

Release date: May 1, 2024
Resolution: 2.49 Å
EM Method: Single-particle
Fitted PDBs: 8p2h
Q-score: 0.6

Gonzalez-Lopez A, Larsson D, Nelson B, Hergenrother PJ, Selmer M

To Be Published

Sample:

Trna (24 kDa, RNA from Escherichia coli)
30s ribosomal protein s7 (17 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s6 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s12 (15 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l6 (19 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s18 (9 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
1,4-diaminobutane (88 Da, Ligand)
30s ribosomal protein s9 (14 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l21 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l17 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s5 (17 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Elongation factor g (76 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l16 (16 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Magnesium ion (24 Da, Ligand)
30s ribosomal protein s8 (14 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l31 type b (9 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l4 (22 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s2 (29 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s15 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l35 (7 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
5s ribosomal rna (36 kDa, RNA from Staphylococcus aureus subsp. aureus NCTC 8325)
Large ribosomal subunit protein bl33a (5 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l19 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l5 (20 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s11 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l15 (15 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l20 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s17 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Spermidine (145 Da, Ligand)
Large ribosomal subunit protein bl32 (6 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Staphylococcus aureus 70s ribosome with elongation factor g and fusidic acid (2 MDa, Complex from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l3 (23 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l22 (12 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l36 (4 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
23s ribosomal rna (946 kDa, RNA from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s16 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Small ribosomal subunit protein us10 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s14 type z (7 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l2 (30 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s3 (24 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l23 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l28 (6 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s20 (9 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Zinc ion (65 Da, Ligand)
50s ribosomal protein l29 (8 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l14 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l25 (23 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s13 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s4 (23 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Fusidic acid (516 Da, Ligand)
Mrna (7 kDa, RNA from Escherichia coli)
50s ribosomal protein l34 (5 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l13 (16 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l30 (6 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l27 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
30s ribosomal protein s19 (10 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
16s ribosomal rna (503 kDa, RNA from Staphylococcus aureus subsp. aureus NCTC 8325)
50s ribosomal protein l24 (11 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)
Guanosine-5'-diphosphate (443 Da, Ligand)
50s ribosomal protein l18 (13 kDa, Protein from Staphylococcus aureus subsp. aureus NCTC 8325)

[Show more]

EMD-34500

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Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.

Release date: May 1, 2024
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h6e
Q-score: 0.236

Zhang W, Zhang X, Zhan X, Bai R, Lei J, Yan C, Shi Y

Cell Res (2024) [ Pubmed: 38658629 DOI: doi:10.1038/s41422-024-00949-w ]

Sample:

U6 snrna-associated sm-like protein lsm3 (11 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
Isoform sm-b of small nuclear ribonucleoprotein-associated proteins b and b' (23 kDa, Protein from Homo sapiens)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
Thioredoxin-like protein 4a (16 kDa, Protein from Homo sapiens)
U4/u6.u5 tri-snrnp-associated protein 2 (65 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Pre-mrna (45 kDa, RNA from Homo sapiens)
Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
U2 snrna (60 kDa, RNA from Homo sapiens)
Guanosine-5'-triphosphate (523 Da, Ligand)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
Probable atp-dependent rna helicase ddx23 (95 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm4 (15 kDa, Protein from Homo sapiens)
Rna-binding protein 42 (50 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm5 (9 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm2 (10 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm8 (10 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm7 (11 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm6 (9 kDa, Protein from Homo sapiens)
Inositol hexakisphosphate (660 Da, Ligand)
U4/u6.u5 tri-snrnp-associated protein 1 (90 kDa, Protein from Homo sapiens)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
Serine/threonine-protein kinase prp4 homolog (117 kDa, Protein from Homo sapiens)
U6 snrna (34 kDa, RNA from Homo sapiens)
Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
Nhp2-like protein 1 (14 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
U4/u6 small nuclear ribonucleoprotein prp3 (77 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
Exon-defined post pre-b spliceosome (2 MDa, Complex from Homo sapiens)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
U5 snrna (37 kDa, RNA from Homo sapiens)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
U4/u6 small nuclear ribonucleoprotein prp31 (55 kDa, Protein from Homo sapiens)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
U4/u6.u5 small nuclear ribonucleoprotein 27 kda protein (18 kDa, Protein from Homo sapiens)
U4 snrna (46 kDa, RNA from Homo sapiens)
Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
U4/u6 small nuclear ribonucleoprotein prp4 (58 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)

[Show more]

EMD-34505

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Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.

Release date: May 1, 2024
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8h6j
Q-score: 0.224

Zhang W, Zhang X, Zhan X, Bai R, Lei J, Yan C, Shi Y

Cell Res (2024) [ Pubmed: 38658629 DOI: doi:10.1038/s41422-024-00949-w ]

Sample:

U6 snrna-associated sm-like protein lsm3 (11 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
Isoform sm-b of small nuclear ribonucleoprotein-associated proteins b and b' (23 kDa, Protein from Homo sapiens)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
Thioredoxin-like protein 4a (16 kDa, Protein from Homo sapiens)
U4/u6.u5 tri-snrnp-associated protein 2 (65 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Pre-mrna (45 kDa, RNA from Homo sapiens)
Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
U2 snrna (60 kDa, RNA from Homo sapiens)
Guanosine-5'-triphosphate (523 Da, Ligand)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
Probable atp-dependent rna helicase ddx23 (95 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm4 (15 kDa, Protein from Homo sapiens)
Rna-binding protein 42 (50 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm5 (9 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm2 (10 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm8 (10 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm7 (11 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm6 (9 kDa, Protein from Homo sapiens)
Inositol hexakisphosphate (660 Da, Ligand)
U4 snrna (46 kDa, RNA from Homo sapiens)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
U4/u6.u5 tri-snrnp-associated protein 1 (90 kDa, Protein from Homo sapiens)
Serine/threonine-protein kinase prp4 homolog (117 kDa, Protein from Homo sapiens)
U6 snrna (34 kDa, RNA from Homo sapiens)
Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
Nhp2-like protein 1 (14 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
U4/u6 small nuclear ribonucleoprotein prp3 (77 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
Exon-defined post pre-b spliceosome (2 MDa, Complex from Homo sapiens)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
U5 snrna (37 kDa, RNA from Homo sapiens)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
U4/u6 small nuclear ribonucleoprotein prp31 (55 kDa, Protein from Homo sapiens)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
U4/u6.u5 small nuclear ribonucleoprotein 27 kda protein (18 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
U4/u6 small nuclear ribonucleoprotein prp4 (58 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)

[Show more]

EMD-34507

Download Map 3D View

Cryo-EM structure of human exon-defined spliceosome in the mature B state.

Release date: May 1, 2024
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8h6k

Zhang W, Zhang X, Zhan X, Bai R, Lei J, Yan C, Shi Y

Cell Res (2024) [ Pubmed: 38658629 DOI: doi:10.1038/s41422-024-00949-w ]

Sample:

U6 snrna-associated sm-like protein lsm3 (11 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
Isoform sm-b of small nuclear ribonucleoprotein-associated proteins b and b' (23 kDa, Protein from Homo sapiens)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase h (19 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
Zinc finger matrin-type protein 2 (23 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor 38a (37 kDa, Protein from Homo sapiens)
Thioredoxin-like protein 4a (16 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Pre-mrna (45 kDa, RNA from Homo sapiens)
Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
U2 snrna (60 kDa, RNA from Homo sapiens)
Guanosine-5'-triphosphate (523 Da, Ligand)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
U4 snrna (46 kDa, RNA from Homo sapiens)
Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm4 (15 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm5 (9 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm2 (10 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm8 (10 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
Wd40 repeat-containing protein smu1 (57 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm7 (11 kDa, Protein from Homo sapiens)
Microfibrillar-associated protein 1 (52 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm6 (9 kDa, Protein from Homo sapiens)
Inositol hexakisphosphate (660 Da, Ligand)
U4/u6.u5 tri-snrnp-associated protein 1 (90 kDa, Protein from Homo sapiens)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
U6 snrna (34 kDa, RNA from Homo sapiens)
Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
Ubiquitin-like protein 5 (8 kDa, Protein from Homo sapiens)
Nhp2-like protein 1 (14 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
U4/u6 small nuclear ribonucleoprotein prp3 (77 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
Exon-defined post pre-b spliceosome (2 MDa, Complex from Homo sapiens)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
U5 snrna (37 kDa, RNA from Homo sapiens)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
U4/u6 small nuclear ribonucleoprotein prp31 (55 kDa, Protein from Homo sapiens)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
U4/u6 small nuclear ribonucleoprotein prp4 (58 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
Ww domain-binding protein 4 (42 kDa, Protein from Homo sapiens)
Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)

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EMD-34508

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Cryo-EM structure of human exon-defined spliceosome in the early B state.

Release date: May 1, 2024
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8h6l
Q-score: 0.283

Zhang W, Zhang X, Zhan X, Bai R, Lei J, Yan C, Shi Y

Cell Res (2024) [ Pubmed: 38658629 DOI: doi:10.1038/s41422-024-00949-w ]

Sample:

U6 snrna-associated sm-like protein lsm3 (11 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
Isoform sm-b of small nuclear ribonucleoprotein-associated proteins b and b' (23 kDa, Protein from Homo sapiens)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase h (19 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
Thioredoxin-like protein 4a (16 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Pre-mrna (45 kDa, RNA from Homo sapiens)
Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
U2 snrna (60 kDa, RNA from Homo sapiens)
Guanosine-5'-triphosphate (523 Da, Ligand)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
U4 snrna (46 kDa, RNA from Homo sapiens)
Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm4 (15 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm5 (9 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm2 (10 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm8 (10 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
Wd40 repeat-containing protein smu1 (57 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm7 (11 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
U6 snrna-associated sm-like protein lsm6 (9 kDa, Protein from Homo sapiens)
Inositol hexakisphosphate (660 Da, Ligand)
U4/u6.u5 tri-snrnp-associated protein 1 (90 kDa, Protein from Homo sapiens)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
U6 snrna (34 kDa, RNA from Homo sapiens)
Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
Nhp2-like protein 1 (14 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
U4/u6 small nuclear ribonucleoprotein prp3 (77 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
Exon-defined post pre-b spliceosome (2 MDa, Complex from Homo sapiens)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
U5 snrna (37 kDa, RNA from Homo sapiens)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
U4/u6 small nuclear ribonucleoprotein prp31 (55 kDa, Protein from Homo sapiens)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
U4/u6 small nuclear ribonucleoprotein prp4 (58 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
Ww domain-binding protein 4 (42 kDa, Protein from Homo sapiens)
Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)

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