Structure of alpha1B and betaI/IVb microtubule bound to GMPCPP
bioRxiv (2023) [ DOI: doi:10.1101/2023.12.01.569594 ]
- Tubulin alpha-1b chain (50 kDa, Protein from Homo sapiens)
- Alpha1b and betai/ivb microtubule (300 kDa, Complex from Homo sapiens)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
Structure of the SARS-CoV-2 EG.5.1 spike RBD in complex with ACE2
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8xln
Q-score: 0.447
Nomai T, Anraku Y, Kita S, Hashiguchi T, Maenaka K
bioRxiv (2024) [ DOI: doi:10.1101/2023.10.19.563209 ]
- Sars-cov-2 eg.5.1 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 eg.5.1 spike glycoprotein in complex with ace2 (90 kDa, Complex)
- Angiotensin-converting enzyme 2 (Complex from Homo sapiens)
- Processed angiotensin-converting enzyme 2 (70 kDa, Protein from Homo sapiens)
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Structure of Apo CXCR4/Gi complex
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8u4n
Q-score: 0.56
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Apo cxcr4/gi complex (Complex from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Structure of CXCL12-bound CXCR4/Gi complex
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8u4o
Q-score: 0.489
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Cxcl12-bound cxcr4/gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Stromal cell-derived factor 1 (7 kDa, Protein from Homo sapiens)
Structure of AMD3100-bound CXCR4/Gi complex
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8u4p
Q-score: 0.532
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Plerixafor (502 Da, Ligand)
- Amd3100-bound cxcr4/gi complex (Complex from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Structure of REGN7663 Fab-bound CXCR4/Gi complex
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8u4q
Q-score: 0.487
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Regn7663 fab light chain (24 kDa, Protein from Homo sapiens)
- Regn7663 fab-bound cxcr4/gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Regn7663 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Structure of REGN7663-Fab bound CXCR4
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8u4r
Q-score: 0.554
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Regn7663 fab light chain (24 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Regn7663 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Regn7663 fab-bound cxcr4 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Structure of HamAB apo complex from the Escherichia coli Hachiman defense system
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8vx9
Q-score: 0.418
Tuck OT, Adler BA, Armbruster EG, Lahiri A, Hu JJ, Zhou J, Pogliano J, Doudna JA
bioRxiv (2024) [ Pubmed: 38464307 DOI: doi:10.1101/2024.02.29.582594 ]
- Hamb (130 kDa, Protein from Escherichia coli)
- Apo hamab complex (160 kDa, Complex from Escherichia coli)
- Hama (28 kDa, Protein from Escherichia coli)
Structure of HamB-DNA complex, conformation 1, from the Escherichia coli Hachiman defense system
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8vxa
Q-score: 0.462
Tuck OT, Adler BA, Armbruster EG, Lahiri A, Hu JJ, Zhou J, Pogliano J, Doudna JA
bioRxiv (2024) [ Pubmed: 38464307 DOI: doi:10.1101/2024.02.29.582594 ]
- Hamb (130 kDa, Protein from Escherichia coli)
- Hamb-dna complex (155 kDa, Complex from Escherichia coli)
- Dna (40-mer) (12 kDa, DNA from synthetic construct)
Structure of HamB-DNA complex, conformation 2, from the Escherichia coli Hachiman defense system
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8vxc
Q-score: 0.408
Tuck OT, Adler BA, Armbruster EG, Lahiri A, Hu JJ, Zhou J, Pogliano J, Doudna JA
bioRxiv (2024) [ Pubmed: 38464307 DOI: doi:10.1101/2024.02.29.582594 ]
- Hamb (130 kDa, Protein from Escherichia coli)
- Hamb-dna complex (155 kDa, Complex from Escherichia coli)
- Dna (40-mer) (12 kDa, DNA from synthetic construct)