Electron Microscopy Data Bank

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PfRH5-PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003

Release date: Oct. 25, 2023
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8cdd
Q-score: 0.425

Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK

Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]

Sample:

Cy.003 light chain (22 kDa, Protein from Gallus gallus)
Cysteine-rich protective antigen (40 kDa, Protein from Plasmodium falciparum 3D7)
Cy.003 heavy chain (23 kDa, Protein from Gallus gallus)
Rh5-interacting protein (124 kDa, Protein from Plasmodium falciparum 3D7)
Reticulocyte-binding protein homolog 5 (60 kDa, Protein from Plasmodium falciparum 3D7)
Pfrh5-pfcyrpa-pfripr complex bound to fab fragment from antibody cy.003 (Complex from Plasmodium falciparum 3D7)

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EMD-16570

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PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003

Release date: Oct. 25, 2023
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8cde
Q-score: 0.409

Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK

Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]

Sample:

Cy.003 light chain (22 kDa, Protein from Gallus gallus)
Cy.003 (23 kDa, Protein from Gallus gallus)
Rh5-interacting protein (124 kDa, Protein from Plasmodium falciparum 3D7)
Pfcyrpa-pfripr complex bound to fab fragment from antibody cy.003 (Complex from Plasmodium falciparum 3D7)
Cysteine-rich protective antigen (40 kDa, Protein from Plasmodium falciparum 3D7)

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EMD-16635

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PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003 - maps for local refinement on PfRIPR

Release date: Oct. 25, 2023
Resolution: 3.33 Å
EM Method: Single-particle

Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK

Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]

Sample:

Pfcyrpa-pfripr complex bound to fab fragment from antibody cy.003 (Complex from Plasmodium falciparum 3D7)

EMD-16636

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PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003 consensus maps

Release date: Oct. 25, 2023
Resolution: 3.02 Å
EM Method: Single-particle

Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK

Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]

Sample:

Pfcyrpa-pfripr complex bound to fab fragment from antibody cy.003 (Complex from Plasmodium falciparum 3D7)

EMD-16639

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PfRH5-PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003 - local refinement on PfRIPR

Release date: Oct. 25, 2023
Resolution: 3.31 Å
EM Method: Single-particle

Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK

Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]

Sample:

Pfrh5-pfcyrpa-pfripr complex from plasmodium falciparum bound to antibody cy.003 (Complex from Plasmodium falciparum 3D7)

EMD-16640

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PfRH5-PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003 - map with additional PfRIPR tail density

Release date: Oct. 25, 2023
Resolution: 3.95 Å
EM Method: Single-particle

Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK

Nature (2024) 625 pp. 578-584 [ DOI: doi:10.1038/s41586-023-06856-1 Pubmed: 38123677 ]

Sample:

Pfrh5-pfcyrpa-pfripr complex from plasmodium falciparum bound to antibody cy.003 (Complex from Plasmodium falciparum 3D7)

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