Tetrahymena telomerase at 2.9 Angstrom resolution
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7uy6
Q-score: 0.506
He Y, Song H, Chan H, Liu B, Wang Y, Susac L, Zhou ZH, Feigon J
Nature (2022) 608 pp. 813-818 [ Pubmed: 35831498 DOI: doi:10.1038/s41586-022-04931-7 ]
- Tetrahymena telomerase holoenzyme (Complex from Tetrahymena thermophila)
- Telomerase holoenzyme teb3 subunit (14 kDa, Protein from Tetrahymena thermophila)
- Telomere dna (19 kDa, DNA from Tetrahymena thermophila)
- Telomerase rna (50 kDa, RNA from Tetrahymena thermophila)
- Telomerase associated protein p50 (50 kDa, Protein from Tetrahymena thermophila)
- Telomerase holoenzyme teb2 subunit (30 kDa, Protein from Tetrahymena thermophila)
- Telomerase reverse transcriptase (133 kDa, Protein from Tetrahymena thermophila)
- Telomerase la-related protein p65 (64 kDa, Protein from Tetrahymena thermophila)
- Zinc ion (65 Da, Ligand)
- Telomerase holoenzyme teb1 subunit (82 kDa, Protein from Tetrahymena thermophila)
Tetrahymena CST with Polymerase alpha-Primase
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7uy7
Q-score: 0.293
He Y, Song H, Chan H, Liu B, Wang Y, Susac L, Zhou ZH, Feigon J
Nature (2022) 608 pp. 813-818 [ Pubmed: 35831498 DOI: doi:10.1038/s41586-022-04931-7 ]
- Telomere dna (19 kDa, DNA from Tetrahymena thermophila)
- Telomerase-associated protein of 19 kda (19 kDa, Protein from Tetrahymena thermophila)
- Telomerase-associated protein of 75 kda (73 kDa, Protein from Tetrahymena thermophila)
- Dna polymerase (161 kDa, Protein from Tetrahymena thermophila)
- Telomerase associated protein p50 (50 kDa, Protein from Tetrahymena thermophila)
- Tetrahymena cst (Complex from Tetrahymena thermophila)
- Tetrahymena cst-polaprim (Complex)
- Zinc ion (65 Da, Ligand)
- Tetrahymena dna polymerase alpha-primase (Complex from Tetrahymena thermophila)
- Telomerase-associated protein of 45 kda (43 kDa, Protein from Tetrahymena thermophila)
Tetrahymena Polymerase alpha-Primase
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7uy8
Q-score: 0.229
He Y, Song H, Chan H, Liu B, Wang Y, Susac L, Zhou ZH, Feigon J
Nature (2022) 608 pp. 813-818 [ Pubmed: 35831498 DOI: doi:10.1038/s41586-022-04931-7 ]
- Dna polymerase alpha subunit b (68 kDa, Protein from Tetrahymena thermophila)
- Dna polymerase (161 kDa, Protein from Tetrahymena thermophila)
- Dna primase (47 kDa, Protein from Tetrahymena thermophila)
- Tetrahymena polaprim (Complex from Tetrahymena thermophila)
- Eukaryotic-type dna primase, large subunit (64 kDa, Protein from Tetrahymena thermophila)
- Zinc ion (65 Da, Ligand)
Human telomerase H/ACA RNP at 3.3 Angstrom
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7trc
Q-score: 0.498
Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J
Nature (2022) 604 pp. 578-583 [ Pubmed: 35418675 DOI: doi:10.1038/s41586-022-04582-8 ]
- H/aca ribonucleoprotein complex subunit 2 (17 kDa, Protein from Homo sapiens)
- Human telomerase h/aca rnp (Complex from Homo sapiens)
- Telomerase cajal body protein 1 (59 kDa, Protein from Homo sapiens)
- H/aca ribonucleoprotein complex subunit dkc1 (57 kDa, Protein from Homo sapiens)
- Telomerase rna, partial sequence (145 kDa, RNA from Homo sapiens)
- H/aca ribonucleoprotein complex subunit 1 (22 kDa, Protein from Homo sapiens)
- H/aca ribonucleoprotein complex subunit 3 (7 kDa, Protein from Homo sapiens)
Human telomerase catalytic core structure at 3.3 Angstrom
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7trd
Q-score: 0.447
Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J
Nature (2022) 604 pp. 578-583 [ Pubmed: 35418675 DOI: doi:10.1038/s41586-022-04582-8 ]
- Telomeric repeat substrate (5 kDa, DNA from Homo sapiens)
- Telomerase rna, partial sequence (145 kDa, RNA from Homo sapiens)
- Telomerase reverse transcriptase (130 kDa, Protein from Homo sapiens)
- Human telomerase catalytic core with dna-substrate (Complex from Homo sapiens)
Human telomerase catalytic core with shelterin protein TPP1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7tre
Q-score: 0.392
Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J
Nature (2022) 604 pp. 578-583 [ Pubmed: 35418675 DOI: doi:10.1038/s41586-022-04582-8 ]
- Adrenocortical dysplasia protein homolog (17 kDa, Protein from Homo sapiens)
- Telomerase reverse transcriptase (130 kDa, Protein from Homo sapiens)
- Telomerase rna, partial sequence (145 kDa, RNA from Homo sapiens)
- Telomeric repeat substrate (5 kDa, DNA from Homo sapiens)
- Active human telomerase rnp with shelterin protein tpp1 (Complex from Homo sapiens)
Human telomerase catalytic core RNP with H2A/H2B
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7trf
Q-score: 0.369
Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J
Nature (2022) 604 pp. 578-583 [ Pubmed: 35418675 DOI: doi:10.1038/s41586-022-04582-8 ]
- Telomerase reverse transcriptase (130 kDa, Protein from Homo sapiens)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Telomerase rna, partial sequence (145 kDa, RNA from Homo sapiens)
- Telomeric repeat substrate (5 kDa, DNA from Homo sapiens)
- Histone h2a (14 kDa, Protein from Homo sapiens)
- Active human telomerase catalytic core with shelterin protein tpp1 (Complex from Homo sapiens)
Tetrahymena telomerase T3D2 structure at 3.3 Angstrom
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7lma
Q-score: 0.473
He Y, Wang Y, Liu B, Helmling C, Susac L, Cheng R, Zhou ZH, Feigon J
Nature (2021) 593 pp. 454-459 [ Pubmed: 33981033 DOI: doi:10.1038/s41586-021-03529-9 ]
- Telomerase holoenzyme teb3 subunit (14 kDa, Protein from Tetrahymena thermophila)
- Tetrahymena telomerase t3d2 structure at 3.3 angstrom (Complex from Tetrahymena thermophila)
- Telomere dna (9 kDa, DNA from Tetrahymena thermophila)
- Telomerase rna (50 kDa, RNA from Tetrahymena thermophila)
- Telomerase associated protein p50 (50 kDa, Protein from Tetrahymena thermophila)
- Telomerase holoenzyme teb2 subunit (30 kDa, Protein from Tetrahymena thermophila)
- Telomerase reverse transcriptase (133 kDa, Protein from Tetrahymena thermophila)
- Telomerase la-related protein p65 (64 kDa, Protein from Tetrahymena thermophila)
- Zinc ion (65 Da, Ligand)
- Telomerase holoenzyme teb1 subunit (82 kDa, Protein from Tetrahymena thermophila)
Tetrahymena telomerase T5D5 structure at 3.8 Angstrom
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7lmb
Q-score: 0.403
He Y, Wang Y, Liu B, Helmling C, Susac L, Cheng R, Zhou ZH, Feigon J
Nature (2021) 593 pp. 454-459 [ Pubmed: 33981033 DOI: doi:10.1038/s41586-021-03529-9 ]
- Telomerase holoenzyme teb3 subunit (14 kDa, Protein from Tetrahymena thermophila)
- Tetrahymena telomerase t5d5 structure (Complex from Tetrahymena thermophila)
- Telomerase associated protein p50 (50 kDa, Protein from Tetrahymena thermophila)
- Telomerase holoenzyme teb2 subunit (30 kDa, Protein from Tetrahymena thermophila)
- Telomerase reverse transcriptase (133 kDa, Protein from Tetrahymena thermophila)
- Telomere dna (6 kDa, DNA from Tetrahymena thermophila)
- Telomerase la-related protein p65 (64 kDa, Protein from Tetrahymena thermophila)
- Zinc ion (65 Da, Ligand)
- Telomerase holoenzyme teb1 subunit (82 kDa, Protein from Tetrahymena thermophila)
- Telomerase rna (50 kDa, RNA from Tetrahymena thermophila)