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catalytic core of human telomerase holoenzyme
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7v99
Q-score: 0.247
Wan F, Ding Y, Zhang Y, Wu Z, Li S, Yang L, Yan X, Lan P, Li G, Wu J, Lei M
Cell Res (2021) 31 pp. 1275-1290 [ Pubmed: 34782750 DOI: doi:10.1038/s41422-021-00586-7 ]
- Telomerase rna component (145 kDa, RNA from Human)
- Histone h2b type 1-k (13 kDa, Protein from Human)
- Telomerase reverse transcriptase (127 kDa, Protein from Human)
- Histone h2a type 1-b/e (14 kDa, Protein from Human)
- Catalytic core (Complex from Homo sapiens)
- Primer dna (7 kDa, DNA from Homo sapiens)
SARS-CoV-2 RdRP catalytic complex with T33-1 RNA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7dte
Q-score: 0.528
Wu J, Wang H, Liu Q, Li R, Gao Y, Fang X, Zhong Y, Wang M, Wang Q, Rao Z, Gong P
Cell Rep (2021) 37 pp. 109882-109882 [ Pubmed: 34653416 DOI: doi:10.1016/j.celrep.2021.109882 ]
- Sars-cov-2 rna-dependent rna polymerase (Complex)
- Rna (Complex)
- Zinc ion (65 Da, Ligand)
- Rna (33-mer) (10 kDa, RNA from Foot-and-mouth disease virus)
- Rna-directed rna polymerase (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 rna-dependent rna polymerase catalytic complex (Complex from Severe acute respiratory syndrome coronavirus 2)
- Rna (57-mer) (18 kDa, RNA from Foot-and-mouth disease virus)
- Non-structural protein 8 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
cryo-EM structure of human RNA polymerase III in elongating state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7d58
Q-score: 0.014
Wang Q, Li S, Wan F, Xu Y, Wu Z, Cao M, Lan P, Lei M, Wu J
Nat Struct Mol Biol (2021) 28 pp. 220-227 [ DOI: doi:10.1038/s41594-021-00557-x Pubmed: 33558766 ]
- Dna-directed rna polymerases i and iii subunit rpac2 (15 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc5 (80 kDa, Protein from Homo sapiens)
- Template dna (12 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Homo sapiens)
- Human pol3 ec (Complex from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc2 (127 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc4 (44 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (24 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i and iii subunit rpac1 (39 kDa, Protein from Homo sapiens)
- Non-template dna (12 kDa, DNA from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna-directed rna polymerase iii subunit rpc7 (25 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc8 (22 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc9 (16 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc1 (155 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc6 (35 kDa, Protein from Homo sapiens)
- Rna (6 kDa, RNA from Homo sapiens)
- Dna-directed rna polymerase iii subunit rpc3 (60 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Homo sapiens)
COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7bzf
Q-score: 0.47
Wang Q, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P, Rao Z
Cell (2020) 182 pp. 417-428.e13 [ Pubmed: 32526208 DOI: doi:10.1016/j.cell.2020.05.034 ]
- Rna (5'-r(*up*gp*up*up*cp*gp*ap*cp*gp*ap*cp*ap*cp*a)-3') (4 kDa, RNA from Foot-and-mouth disease virus)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Structure of covid-19 rna-dependent rna polymerase in complex with rna (155 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 8 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna-directed rna polymerase (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Rna (31-mer) (10 kDa, RNA from Foot-and-mouth disease virus)
COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7c2k
Q-score: 0.581
Wang Q, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P, Rao Z
Cell (2020) 182 pp. 417-428.e13 [ Pubmed: 32526208 DOI: doi:10.1016/j.cell.2020.05.034 ]
- Rna (29-mer) (9 kDa, RNA from Foot-and-mouth disease virus)
- Rna-directed rna polymerase (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Covid-19 rna-dependent rna polymerase pre-translocated catalytic complex (Complex from Severe acute respiratory syndrome coronavirus 2)
- Rna (5'-r(*up*gp*up*up*cp*gp*ap*cp*gp*ap*cp*ap*cp*ap*gp*g*(f86)p*g)-3') (5 kDa, RNA from Foot-and-mouth disease virus)
- Non-structural protein 8 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)