Cryo-EM structure of POLRMT mutant.
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7zc4
Q-score: 0.328
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hallberg BM, Falkenberg M
Cell (2022) 185 pp. 2309-2323.e24 [ Pubmed: 35662414 DOI: doi:10.1016/j.cell.2022.05.006 ]
- Dna-directed rna polymerase, mitochondrial (134 kDa, Protein from Homo sapiens)
- Polrmt (137 kDa, Cellular component from Homo sapiens)
Cryo-EM structure of POLRMT in free form.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7pzr
Q-score: 0.385
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hallberg BM, Falkenberg M
Cell (2022) 185 pp. 2309-2323.e24 [ Pubmed: 35662414 DOI: doi:10.1016/j.cell.2022.05.006 ]
- Dna-directed rna polymerase, mitochondrial (137 kDa, Protein from Homo sapiens)
- Polrmt (137 kDa, Complex from Homo sapiens)
Mitochondrial DNA dependent RNA polymerase homodimer.
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7pzp
Q-score: 0.323
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hallberg BM, Falkenberg M
Cell (2022) 185 pp. 2309- [ Pubmed: 35662414 DOI: doi:10.1016/j.cell.2022.05.006 ]
- Polrmt (137 kDa, Complex)
- Dna-directed rna polymerase, mitochondrial (137 kDa, Protein from Homo sapiens)
- Mitochondrial dna-directed rna polymerase dimer. (Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7ctt
Q-score: 0.478
Peng Q, Peng R, Yuan B, Wang M, Zhao J, Fu L, Qi J, Shi Y
Innovation (NY) (2021) 2 pp. 100080-100080 [ Pubmed: 33521757 DOI: doi:10.1016/j.xinn.2021.100080 ]
- Non-structural protein 8 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- [[(2~{r},3~{s},4~{r},5~{r})-5-(3-aminocarbonyl-5-fluoranyl-2-oxidanylidene-pyrazin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (529 Da, Ligand)
- Rna-directed rna polymerase (106 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The complex of favipiravir bound to core polymerase from sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Primer-rna (5'-r(p*up*up*cp*up*cp*cp*up*ap*ap*gp*ap*ap*gp*cp*up*a)-3') (6 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Template-rna (5'-r(p*ap*cp*up*ap*gp*cp*up*up*cp*up*up*ap*gp*gp*ap*gp*ap*a)-3') (12 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
Structure of the RNA-dependent RNA polymerase from SARS-CoV-2
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7bw4
Q-score: 0.417
Peng Q, Peng R, Yuan B, Zhao J, Wang M, Wang X, Wang Q, Sun Y, Fan Z, Qi J, Gao GF, Shi Y
Cell Rep (2020) 31 pp. 107774-107774 [ DOI: doi:10.1016/j.celrep.2020.107774 Pubmed: 32531208 ]
- Rna-directed rna polymerase (105 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 8 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The complex of nsp12 bound to nsp7 and nsp8 (Complex from SARS coronavirus)
- Zinc ion (65 Da, Ligand)