Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research. We appreciate your responses prior to closing of the survey on Monday 17th June.
Structure of HIV-1 reverse transcriptase initiation complex core
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7kjv
Q-score: 0.564
Ha B, Larsen KP, Zhang J, Fu Z, Montabana E, Jackson LN, Chen DH, Puglisi EV
Nat Commun (2021) 12 pp. 2500-2500 [ Pubmed: 33947853 DOI: doi:10.1038/s41467-021-22628-9 ]
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 group M subtype B (isolate BH10))
- Octyl beta-d-glucopyranoside (292 Da, Ligand)
- Reverse transcriptase p51 subunit (51 kDa, Protein from Human immunodeficiency virus 1)
- Trna lysine 3 fragment with gnra tetraloop (12 kDa, Macromolecule from Homo sapiens)
- Hiv-1 reverse transcriptase initiation complex core (138 kDa, Complex from Human immunodeficiency virus 1)
- Magnesium ion (24 Da, Ligand)
- Hiv-1 viral rna fragment (8 kDa, RNA from Human immunodeficiency virus 1)
Structure of HIV-1 reverse transcriptase initiation complex core with efavirenz
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7kjw
Q-score: 0.55
Ha B, Larsen KP, Zhang J, Fu Z, Montabana E, Jackson LN, Chen DH, Puglisi EV
Nat Commun (2021) 12 pp. 2500-2500 [ Pubmed: 33947853 DOI: doi:10.1038/s41467-021-22628-9 ]
- Hiv-1 reverse transcriptase initiation complex core with efavirenz (138 kDa, Complex from Human immunodeficiency virus 1)
- Reverse transcriptase p51 subunit (51 kDa, Protein from Human immunodeficiency virus 1)
- (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2h-3,1-benzoxazin-2-one (315 Da, Ligand)
- Trna lysine 3 fragment with gnra tetraloop (12 kDa, Macromolecule from Homo sapiens)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 group M subtype B (isolate BH10))
- Magnesium ion (24 Da, Ligand)
- Hiv-1 viral rna fragment (8 kDa, RNA from Human immunodeficiency virus 1)
Structure of HIV-1 reverse transcriptase initiation complex core with nevirapine
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7kjx
Q-score: 0.515
Ha B, Larsen KP, Zhang J, Fu Z, Montabana E, Jackson LN, Chen DH, Puglisi EV
Nat Commun (2021) 12 pp. 2500-2500 [ Pubmed: 33947853 DOI: doi:10.1038/s41467-021-22628-9 ]
- Trna lysine 3 fragment with gnra tetraloop (7 kDa, Macromolecule from Homo sapiens)
- 11-cyclopropyl-5,11-dihydro-4-methyl-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (266 Da, Ligand)
- Reverse transcriptase p51 subunit (51 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 reverse transcriptase initiation complex core with nevirapine (138 kDa, Complex from Human immunodeficiency virus 1)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 group M subtype B (isolate BH10))
- Magnesium ion (24 Da, Ligand)
- Hiv-1 viral rna fragment (8 kDa, RNA from Human immunodeficiency virus 1)
+1 extended HIV-1 reverse transcriptase initiation complex core (pre-translocation state)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6waz
Q-score: 0.387
Larsen KP, Choi J, Jackson LN, Kappel K, Zhang J, Ha B, Chen DH, Puglisi EV
J Mol Biol (2020) 432 pp. 4499-4522 [ DOI: doi:10.1016/j.jmb.2020.06.003 Pubmed: 32512005 ]
- Reverse transcriptase p51 subunit (51 kDa, Protein from Human immunodeficiency virus 1)
- Trna lysine 3 (24 kDa, Macromolecule from Homo sapiens)
- Hiv-1 viral rna genome fragment (32 kDa, RNA from Human immunodeficiency virus 1)
- Trna lysine 3 (Complex from Homo sapiens)
- Hiv-1 reverse transcriptase (Complex from Human immunodeficiency virus 1)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus 1)
- +1 extended hiv-1 reverse transcriptase initiation complex core (25 kDa, Complex from Human immunodeficiency virus 1)
- Hiv-1 rna genome fragment (Complex from Human immunodeficiency virus 1)
+3 extended HIV-1 reverse transcriptase initiation complex core (intermediate state)
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 6wb1
Q-score: 0.304
Larsen KP, Choi J, Jackson LN, Kappel K, Zhang J, Ha B, Chen DH, Puglisi EV
J Mol Biol (2020) 432 pp. 4499-4522 [ DOI: doi:10.1016/j.jmb.2020.06.003 Pubmed: 32512005 ]
- +3 extended hiv-1 reverse transcriptase initiation complex core (intermediate state) (25 kDa, Complex from Human immunodeficiency virus 1)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 group M subtype B (isolate BH10))
- Hiv-1 viral rna genome fragment (32 kDa, RNA from Human immunodeficiency virus 1)
- Trna lysine 3 (Complex from Homo sapiens)
- Hiv-1 reverse transcriptase (Complex from Human immunodeficiency virus 1)
- Reverse transcriptase p51 subunit (51 kDa, Protein from Human immunodeficiency virus 1)
- Trna lysine 3 (25 kDa, Macromolecule from Homo sapiens)
- Hiv-1 rna genome fragment (Complex from Human immunodeficiency virus 1)
Architecture of HIV-1 reverse transcriptase initiation complex core
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6b19
Q-score: 0.301
Larsen KP, Mathiharan YK, Kappel K, Coey AT, Chen DH, Barrero D, Madigan L, Puglisi JD, Skiniotis G, Puglisi EV
Nature (2018) 557 pp. 118-122 [ DOI: doi:10.1038/s41586-018-0055-9 Pubmed: 29695867 ]
- Trna lysine3 primer (25 kDa, Complex from Homo sapiens)
- Rna genome fragment (32 kDa, RNA from Human immunodeficiency virus 1)
- Hiv-1 reverse transcription initiation complex core (175 kDa, Complex)
- Trna lysine3 (24 kDa, Macromolecule from Homo sapiens)
- Hiv-1 reverse transcriptase (117 kDa, Complex from Human immunodeficiency virus 1)
- Reverse transcriptase p66 subunit (65 kDa, Protein from Human immunodeficiency virus 1)
- Reverse transcriptase p51 subunit (51 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 rna genome fragment (33 kDa, Complex from Human immunodeficiency virus 1)