Cryo-EM structure of MLE in complex with SL7UUC RNA and ADP
Resolution: 4.24 Å
EM Method: Single-particle
Fitted PDBs: 8pjj
Q-score: 0.218
Jagtap PKA, Muller M, Kiss AE, Thomae AW, Lapouge K, Beck M, Becker PB, Hennig J
Mol Cell (2023) 83 pp. 4318-4333.e10 [ DOI: doi:10.1016/j.molcel.2023.10.026 Pubmed: 37989319 ]
- Dosage compensation regulator (130 kDa, Protein from Drosophila melanogaster)
- Dosage compensation regulator (Complex from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Sl7uuc rna (19 kDa, RNA from Drosophila melanogaster)
- Sl7uuc rna (Complex from Drosophila melanogaster)
- Complex of mle, sl7uuc and adp (150 kDa, Complex)
Cryo-EM structure of MLE in complex with UUC RNA and ADP
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8pjb
Q-score: 0.415
Jagtap PKA, Muller M, Kiss AE, Thomae AW, Lapouge K, Beck M, Becker PB, Hennig J
Mol Cell (2023) 83 pp. 4318-4333.e10 [ DOI: doi:10.1016/j.molcel.2023.10.026 Pubmed: 37989319 ]
- Rna (5'-r(p*cp*up*cp*up*up*up*cp*up*u)-3') (Complex from Drosophila melanogaster)
- Dosage compensation regulator (130 kDa, Protein from Drosophila melanogaster)
- Dosage compensation regulator (Complex from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Complex of mle, uuc and adp (134 kDa, Complex)
- Rna (5'-r(p*cp*up*cp*up*up*up*cp*up*u)-3') (3 kDa, RNA from Drosophila melanogaster)
Cryo-EM structure of MLE in complex with ADP:AlF4 and U10 RNA
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8b9g
Q-score: 0.513
Jagtap PKA, Muller M, Kiss AE, Thomae AW, Lapouge K, Beck M, Becker PB, Hennig J
Mol Cell (2023) 83 pp. 4318-4333.e10 [ DOI: doi:10.1016/j.molcel.2023.10.026 Pubmed: 37989319 ]
- Rna (5'-r(p*up*up*up*up*up*up*up*up*up*up*u)-3') (3 kDa, RNA from Drosophila melanogaster)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Mle in complex with adp:alf4 and u10 rna (133 kDa, Complex from Drosophila melanogaster)
- Water (18 Da, Ligand)
- Dosage compensation regulator (130 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Cryo-EM structure of MLE in complex with ADP:AlF4 and UUC RNA
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8b9i
Q-score: 0.469
Jagtap PKA, Muller M, Kiss AE, Thomae AW, Lapouge K, Beck M, Becker PB, Hennig J
Mol Cell (2023) 83 pp. 4318-4333.e10 [ DOI: doi:10.1016/j.molcel.2023.10.026 Pubmed: 37989319 ]
- Mle in complex with adp:alf4 and uuc rna (133 kDa, Complex from Drosophila melanogaster)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Water (18 Da, Ligand)
- Dosage compensation regulator (130 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Rna (5'-r(p*cp*cp*up*cp*up*up*up*cp*up*up*u)-3') (3 kDa, RNA from Drosophila melanogaster)
Cryo-EM structure of MLE in complex with ADP:AlF4
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8b9j
Q-score: 0.416
Jagtap PKA, Muller M, Kiss AE, Thomae AW, Lapouge K, Beck M, Becker PB, Hennig J
Mol Cell (2023) 83 pp. 4318-4333.e10 [ DOI: doi:10.1016/j.molcel.2023.10.026 Pubmed: 37989319 ]
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Mle in complex with adp:alf4 (130 kDa, Cellular component from Drosophila melanogaster)
- Dosage compensation regulator (130 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of MLE in complex with ADP:AlF4 and SL7modUUC RNA
Resolution: 4.04 Å
EM Method: Single-particle
Fitted PDBs: 8b9k
Q-score: 0.239
Jagtap PKA, Muller M, Kiss AE, Thomae AW, Lapouge K, Beck M, Becker PB, Hennig J
Mol Cell (2023) 83 pp. 4318-4333.e10 [ DOI: doi:10.1016/j.molcel.2023.10.026 Pubmed: 37989319 ]
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Sl7moduuc (19 kDa, RNA from Drosophila melanogaster)
- Dosage compensation regulator (130 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Mle in complex with adp:alf4 and sl7moduuc rna (149 kDa, Complex from Drosophila melanogaster)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8b9l
Q-score: 0.345
Jagtap PKA, Muller M, Kiss AE, Thomae AW, Lapouge K, Beck M, Becker PB, Hennig J
Mol Cell (2023) 83 pp. 4318-4333.e10 [ DOI: doi:10.1016/j.molcel.2023.10.026 Pubmed: 37989319 ]
- Dosage compensation regulator (130 kDa, Protein from Drosophila melanogaster)
- Mle (130 kDa, Cellular component from Drosophila melanogaster)
SARS-CoV-2 RdRp in complex with 4 Remdesivir monophosphate
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 7l1f
Q-score: 0.327
Bravo JPK, Dangerfield TL, Taylor DW, Johnson KA
Mol Cell (2021) 81 pp. 1548-1552.e4 [ DOI: doi:10.1016/j.molcel.2021.01.035 Pubmed: 33631104 ]
- Rna (5'-r(p*ap*up*up*up*up*ap*ap*up*ap*gp*cp*up*up*cp*up*up*ap*g)-3') (5 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
- Rna-directed rna polymerase, non-structural protein 8, non-structural protein 7 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (7 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (Complex)
- Non-structural protein 8 (12 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 rdrp complex with template:primer and four rmp (Complex)
- Rna-directed rna polymerase (103 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (5'-r(p*cp*up*ap*ap*gp*ap*ap*gp*cp*up*ap*up*u*(f86)*(f86)*(f86)*(f86))-3') (5 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of yeast mitochondrial RNA polymerase transcription initiation complex
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 6ymw
Q-score: 0.41
De Wijngaert B, Sultana S, Singh A, Dharia C, Vanbuel H, Shen J, Vasilchuk D, Martinez SE, Kandiah E, Patel SS, Das K
Mol Cell (2021) 81 pp. 268- [ DOI: doi:10.1016/j.molcel.2020.11.016 Pubmed: 33278362 ]
- Mitochondria dna-dependent rna polymerase pre-initiation complex (Complex from Saccharomyces cerevisiae)
- Rna (pppgpg) (805 Da, RNA from synthetic construct)
- Dna (Complex from Saccharomyces cerevisiae)
- Chains: n (10 kDa, DNA from Saccharomyces cerevisiae S288C)
- Mitochondrial transcription factor 1 (41 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase, mitochondrial (143 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chains: t (10 kDa, DNA from Saccharomyces cerevisiae S288C)
- Mitochondria dna-dependent rna polymerase pre-initiation complex (202 kDa, Complex)
- [[(2~{r},3~{s},4~{r},5~{r})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl] phosphono hydrogen phosphate (500 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Rna (pppgpg) (Complex from synthetic construct)
Cryo-EM structure of yeast mitochondrial RNA polymerase transcription pre-initiation complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6ymv
Q-score: 0.536
De Wijngaert B, Sultana S, Singh A, Dharia C, Vanbuel H, Shen J, Vasilchuk D, Martinez SE, Kandiah E, Patel SS, Das K
Mol Cell (2021) 81 pp. 268- [ DOI: doi:10.1016/j.molcel.2020.11.016 Pubmed: 33278362 ]
- Dna (33-mer) template (10 kDa, DNA from Saccharomyces cerevisiae)
- Dna (Complex from Saccharomyces cerevisiae)
- Dna-directed rna polymerase, mitochondrial (143 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mitochondrial transcription factor 1 (41 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mitochondria dna-dependent rna polymerase pre-initiation complex (202 kDa, Complex)
- Mitochondria dna-dependent rna polymerase pre-initiation complex (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna (33-mer) non-template (10 kDa, DNA from Saccharomyces cerevisiae)