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F8-A22-E4 complex of MPXV in complex with DNA and Ara-CTP
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8k8s
Q-score: 0.402
Structure (2024) [ DOI: doi:10.1016/j.str.2024.03.004 Pubmed: 38579705 ]
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(*ap*tp*cp*cp*tp*cp*cp*cp*cp*tp*ap*c)-3') (3 kDa, DNA from DNA molecule)
- F8-a22-e4 complex of mpxv in complex with dna and ara-ctp (Complex from Monkeypox virus)
- Uracil-dna glycosylase e4 (25 kDa, Protein from Monkeypox virus)
- Water (18 Da, Ligand)
- Dna polymerase f8 (117 kDa, Protein from Monkeypox virus)
- Dna polymerase processivity factor component a20 (49 kDa, Protein from Monkeypox virus)
- Dna (5'-d(p*tp*ap*gp*gp*tp*ap*gp*gp*gp*gp*ap*gp*gp*ap*t)-3') (5 kDa, DNA from DNA molecule)
- 4-amino-1-{5-o-[(s)-hydroxy{[(r)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-d-arabinofuranosyl}pyrimidin-2(1h)-one (483 Da, Ligand)
F8-A22-E4 complex of MPXV in complex with DNA and dCTP
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8k8u
Q-score: 0.347
Structure (2024) [ DOI: doi:10.1016/j.str.2024.03.004 Pubmed: 38579705 ]
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(*ap*tp*cp*cp*tp*cp*cp*cp*cp*tp*ap*c)-3') (3 kDa, DNA from DNA molecule)
- Cytidine-5'-triphosphate (483 Da, Ligand)
- F8-a22-e4 complex of mpxv in complex with dna and ara-ctp (Complex from Monkeypox virus)
- Uracil-dna glycosylase e4 (25 kDa, Protein from Monkeypox virus)
- Water (18 Da, Ligand)
- Dna polymerase f8 (117 kDa, Protein from Monkeypox virus)
- Dna polymerase processivity factor component a20 (49 kDa, Protein from Monkeypox virus)
- Dna (5'-d(p*ap*ap*gp*gp*tp*ap*gp*gp*gp*gp*ap*gp*gp*ap*t)-3') (5 kDa, DNA from DNA molecule)
the local map of DNA and Ara-CTP binding site
Structure (2024) [ DOI: doi:10.1016/j.str.2024.03.004 Pubmed: 38579705 ]
the local map of DNA and dCTP binding site
Structure (2024) [ DOI: doi:10.1016/j.str.2024.03.004 Pubmed: 38579705 ]
Cryo EM map of SLC7A10 in the apo state
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 8wns
Q-score: 0.406
Li Y, Guo Y, Broer A, Dai L, Yan R
Nat Commun (2024) 15 pp. 3036-3036 [ DOI: doi:10.1038/s41467-024-47468-1 Pubmed: 38589439 ]
- 4f2hc-asc-1 complex (Complex from Homo sapiens)
- Asc-type amino acid transporter 1 (56 kDa, Protein from Homo sapiens)
- Amino acid transporter heavy chain slc3a2 (68 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo EM map of SLC7A10 with L-Alanine substrate
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 8wnt
Q-score: 0.425
Li Y, Guo Y, Broer A, Dai L, Yan R
Nat Commun (2024) 15 pp. 3036-3036 [ DOI: doi:10.1038/s41467-024-47468-1 Pubmed: 38589439 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4f2hc-asc-1 complex (Complex from Homo sapiens)
- Alanine (89 Da, Ligand)
- Asc-type amino acid transporter 1 (56 kDa, Protein from Homo sapiens)
- Amino acid transporter heavy chain slc3a2 (68 kDa, Protein from Homo sapiens)
Cryo EM map of SLC7A10-SLC3A2 complex in the D-serine bound state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8wny
Q-score: 0.456
Li Y, Guo Y, Broer A, Dai L, Yan R
Nat Commun (2024) 15 pp. 3036-3036 [ DOI: doi:10.1038/s41467-024-47468-1 Pubmed: 38589439 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4f2hc-asc-1 complex (Complex from Homo sapiens)
- Asc-type amino acid transporter 1 (56 kDa, Protein from Homo sapiens)
- Amino acid transporter heavy chain slc3a2 (68 kDa, Protein from Homo sapiens)
- D-serine (105 Da, Ligand)
CryoEM structure of NaDC1 with Citrate
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w6c
Q-score: 0.631
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Structure of nadc1 in complex with citrate (Complex from Homo sapiens)
- Citric acid (192 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
CryoEM structure of NaDC1 in apo state
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8w6d
Q-score: 0.662
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Structure of nadc1 in apo state (Complex from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w6g
Q-score: 0.552
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- 2-[[(~{e})-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid (337 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- Nadc1 in complex with inhibitor n-(p-amylcinnamoyl)anthranilic acid (aca) (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)