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1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease and priming loop ordered (Class2a)
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 7nha
Q-score: 0.475
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- 1918 influenza virus polymerase (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from synthetic construct)
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Vrna promoters (Complex from synthetic construct)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters (Complex)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from synthetic construct)
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease ordered (Class2b)
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7nhc
Q-score: 0.553
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- 1918 influenza virus polymerase (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from synthetic construct)
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Vrna promoters (Complex from synthetic construct)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters (Complex)
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from synthetic construct)
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
1918 H1N1 Viral influenza polymerase heterotrimer - full transcriptase (Class1)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 7nhx
Q-score: 0.406
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Influenza virus polymerase heterotrimer (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- 1918 influenza virus polymerase heterotrimer in complex with vrna promoters (Complex)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Vrna promoters (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
1918 H1N1 Viral influenza polymerase heterotrimer - Replicase (class 3)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7ni0
Q-score: 0.385
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Polymerase basic protein 2 (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Polymerase acidic protein (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters (Complex)
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8189 core
Resolution: 6.2 Å
EM Method: Single-particle
Fitted PDBs: 7nik
Q-score: 0.103
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase heterotrimer (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Nanobody8189 core (14 kDa, Protein from Camelidae mixed library)
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotrimer in complex with vrna promoters and nb8189 (Complex)
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Nb8189 (Complex from Camelidae mixed library)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8190 core
Resolution: 5.01 Å
EM Method: Single-particle
Fitted PDBs: 7nil
Q-score: 0.137
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase heterotrimer (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8190 (Complex)
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Nanobody8190 core (14 kDa, Protein from Camelidae mixed library)
- Nanobody8190 (Complex from Camelidae mixed library)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8191 core
Resolution: 6.7 Å
EM Method: Single-particle
Fitted PDBs: 7nir
Q-score: 0.086
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nanobody8191 core (14 kDa, Protein from Camelidae mixed library)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nanobody8191 core (Complex from Camelidae mixed library)
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Polymerase acidic protein, rna-directed rna polymerase catalytic subunit, polymerase basic protein 2 (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8191 (Complex)
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8192 core
Resolution: 5.96 Å
EM Method: Single-particle
Fitted PDBs: 7nis
Q-score: 0.057
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Nanobody8192 core (Complex from Camelidae mixed library)
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8192 (Complex)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Nanobody8192 core (14 kDa, Protein from Camelidae mixed library)
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Polymerase acidic protein, rna-directed rna polymerase catalytic subunit, polymerase basic protein 2 (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8196 core
Resolution: 4.48 Å
EM Method: Single-particle
Fitted PDBs: 7nj3
Q-score: 0.151
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
- Nanobody8196 core (Complex from Camelidae mixed library)
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8196 (Complex)
- Nanobody8196 core (14 kDa, Protein from Camelidae mixed library)
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Polymerase acidic protein, rna-directed rna polymerase catalytic subunit, polymerase basic protein 2 (Complex from Influenza A virus (strain A/Brevig Mission/1/1918 H1N1))
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8198 core
Resolution: 5.84 Å
EM Method: Single-particle
Fitted PDBs: 7nj4
Q-score: 0.079
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Serna Martin I, Pardon E, Steyaert J, Fodor E, Grimes JM
Nat Commun (2022) 13 pp. 251-251 [ Pubmed: 35017564 DOI: doi:10.1038/s41467-021-27950-w ]
- Rna-directed rna polymerase catalytic subunit (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*ap*gp*up*ap*gp*ap*ap*ap*cp*ap*ap*gp*gp*cp*c)-3') (4 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8198 core (Complex from Camelidae mixed library)
- 1918 influenza virus polymerase heterotirmer in complex with vrna promoters and nb8196 (Complex)
- Polymerase basic protein 2,immunoglobulin g-binding protein a (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (5'-r(p*gp*gp*cp*cp*up*gp*cp*u)-3') (5 kDa, RNA from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase acidic protein (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Polymerase basic protein 2,immunoglobulin g-binding protein a (102 kDa, Protein from Staphylococcus aureus)
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Rna (Complex from Influenza A virus (A/Brevig Mission/1/1918(H1N1)))
- Nb8198 core (15 kDa, Protein from Camelidae mixed library)