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I53_dn5 nanoparticle displaying the trimeric HA heads with heptad domain, TH-1heptad-I53_dn5
Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP
Cell Rep (2023) 42 pp. 113552-113552 [ DOI: doi:10.1016/j.celrep.2023.113552 Pubmed: 38096058 ]
- Trimer head ha (Protein from synthetic construct)
- Trimer head ha (Complex from synthetic construct)
- Pentamer (Protein from synthetic construct)
- I53_dn5 nanoparticle displaying the trimeric ha heads with heptad domain, th-1heptad-i53_dn5 (Complex)
- Pentamer (Complex from synthetic construct)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8ur5
Q-score: 0.429
Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP
Cell Rep (2023) 42 pp. 113552-113552 [ DOI: doi:10.1016/j.celrep.2023.113552 Pubmed: 38096058 ]
- I53_dn5 nanoparticle displaying the trimeric ha heads with heptad domain, th-1heptad-i53_dn5 (local refinement of th-1heptad) (Complex)
- Trimer head ha,hemagglutinin ha1 chain (44 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Trimer head ha (Complex from synthetic construct)
I53_dn5 nanoparticle displaying the trimeric HA heads with heptad domain, TH-2heptad-I53_dn5
Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP
Cell Rep (2023) 42 pp. 113552-113552 [ DOI: doi:10.1016/j.celrep.2023.113552 Pubmed: 38096058 ]
- Trimer head ha (Protein from synthetic construct)
- I53_dn5 nanoparticle displaying the trimeric ha heads with heptad domain, th-2heptad-i53_dn5 (Complex)
- Trimer head ha (Complex from synthetic construct)
- Pentamer (Protein from synthetic construct)
- Pentamer (Complex from synthetic construct)
I53_dn5 nanoparticle displaying the trimeric HA heads with heptad domain, TH-6heptad-I53_dn5
Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP
Cell Rep (2023) 42 pp. 113552-113552 [ DOI: doi:10.1016/j.celrep.2023.113552 Pubmed: 38096058 ]
- Trimer head ha (Protein from synthetic construct)
- I53_dn5 nanoparticle displaying the trimeric ha heads with heptad domain, th-6heptad-i53_dn5 (Complex)
- Trimer head ha (Complex from synthetic construct)
- Pentamer (Protein from synthetic construct)
- Pentamer (Complex from synthetic construct)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8ur7
Q-score: 0.403
Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP
Cell Rep (2023) 42 pp. 113552-113552 [ DOI: doi:10.1016/j.celrep.2023.113552 Pubmed: 38096058 ]
- Trimer head ha,hemagglutinin ha1 chain (48 kDa, Protein from synthetic construct)
- I53_dn5 nanoparticle displaying the trimeric ha heads with heptad domain, th-6heptad-i53_dn5 (Complex)
- Trimer head ha (Complex from synthetic construct)
- Pentamer (Complex from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Influenza Neuraminidase N1-CA09-sNAp-155
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7u2q
Q-score: 0.514
Ellis D, Lederhofer J, Acton OJ, Tsybovsky Y, Kephart S, Yap C, Gillespie RA, Creanga A, Olshefsky A, Stephens T, Pettie D, Murphy M, Sydeman C, Ahlrichs M, Chan S, Borst AJ, Park YJ, Lee KK, Graham BS, Veesler D, King NP, Kanekiyo M
Nat Commun (2022) 13 pp. 1825-1825 [ DOI: doi:10.1038/s41467-022-29416-z Pubmed: 35383176 ]
- Influenza n1-ca09-snap-155 (42 kDa, Protein from Influenza A virus)
- Structure-based design of an engineered influenza neuraminidase tetramer (210 MDa, Complex from Influenza A virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Influenza Neuraminidase N1-MI15-sNAp-174
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7u2t
Q-score: 0.505
Ellis D, Lederhofer J, Acton OJ, Tsybovsky Y, Kephart S, Yap C, Gillespie RA, Creanga A, Olshefsky A, Stephens T, Pettie D, Murphy M, Sydeman C, Ahlrichs M, Chan S, Borst AJ, Park YJ, Lee KK, Graham BS, Veesler D, King NP, Kanekiyo M
Nat Commun (2022) 13 pp. 1825-1825 [ DOI: doi:10.1038/s41467-022-29416-z Pubmed: 35383176 ]
- Structure-based design of an engineered influenza neuraminidase tetramer (210 MDa, Complex from Influenza A virus)
- Influenza n1-mi15-snap-174 (42 kDa, Protein from Influenza A virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinson GB, Park YJ, Moin SM, Acton OJ, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L, Creanga A, Watson MJ, Kephart S, Ataca S, Vaile JR, Ueda G, Crank MC, Stewart L, Lee KK, Guttman M, Baker D, Mascola JR, Veesler D, Graham BS, King NP, Kanekiyo M
Nature (2021) 592 pp. 623-628 [ Pubmed: 33762730 DOI: doi:10.1038/s41586-021-03365-x ]
Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinson GB, Park YJ, Moin SM, Acton OJ, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L, Creanga A, Watson MJ, Kephart S, Ataca S, Vaile JR, Ueda G, Crank MC, Stewart L, Lee KK, Guttman M, Baker D, Mascola JR, Veesler D, Graham BS, King NP, Kanekiyo M
Nature (2021) 592 pp. 623-628 [ Pubmed: 33762730 DOI: doi:10.1038/s41586-021-03365-x ]
Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinson GB, Park YJ, Moin SM, Acton OJ, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L, Creanga A, Watson MJ, Kephart S, Ataca S, Vaile JR, Ueda G, Crank MC, Stewart L, Lee KK, Guttman M, Baker D, Mascola JR, Veesler D, Graham BS, King NP, Kanekiyo M
Nature (2021) 592 pp. 623-628 [ Pubmed: 33762730 DOI: doi:10.1038/s41586-021-03365-x ]