Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8sgo
Q-score: 0.575
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ DOI: doi:10.1038/s41467-023-40800-1 Pubmed: 37607940 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Pregnenolone sulfate (396 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and pregnenolone sulfate (Complex from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8si9
Q-score: 0.524
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ DOI: doi:10.1038/s41467-023-40800-1 Pubmed: 37607940 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Allopregnanolone (318 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and allopregnanolone (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8sid
Q-score: 0.539
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ DOI: doi:10.1038/s41467-023-40800-1 Pubmed: 37607940 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- 17-oxoandrost-5-en-3beta-yl hydrogen sulfate (368 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and dehydroepiandrosterone sulfate (Complex from Homo sapiens)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)