Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7qhb
Q-score: 0.453
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ DOI: doi:10.1038/s41467-022-28404-7 Pubmed: 35136046 ]
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Palmitoleic acid (254 Da, Ligand)
- Cyclothiazide (389 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- (2s)-2,3-dihydroxypropyl (7z)-hexadec-7-enoate (328 Da, Ligand)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
Active state of GluA1/A2 AMPA receptor in complex with TARP gamma-8 (TMD)
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ DOI: doi:10.1038/s41467-022-28404-7 Pubmed: 35136046 ]
- Ampa glutamate receptor 2, isoform flip, q/r edited (Protein from Rattus norvegicus)
- Tarp gamma 8 (Protein from Rattus norvegicus)
- Ampa glutamate receptor 1, isoform flip (Protein from Rattus norvegicus)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
Active state of GluA1/A2 AMPA receptor in complex with TARP gamma-8 (LBD)
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ DOI: doi:10.1038/s41467-022-28404-7 Pubmed: 35136046 ]
- Tarp gamma 8 (Protein from Rattus norvegicus)
- Ampa glutamate receptor 2, isoform flip, q/r edited (Protein from Rattus norvegicus)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- Ampa glutamate receptor 1, isoform flip (Protein from Rattus norvegicus)
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7qhh
Q-score: 0.359
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ DOI: doi:10.1038/s41467-022-28404-7 Pubmed: 35136046 ]
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Palmitoleic acid (254 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- (2s)-2,3-dihydroxypropyl (7z)-hexadec-7-enoate (328 Da, Ligand)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD)
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ DOI: doi:10.1038/s41467-022-28404-7 Pubmed: 35136046 ]
- Tarp gamma 8 (Protein from Rattus norvegicus)
- Ampa glutamate receptor 2, flip isoform, q/r edited (Protein from Rattus norvegicus)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- Ampa glutamate receptor 1, flip isoform (Protein from Rattus norvegicus)
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (LBD)
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ DOI: doi:10.1038/s41467-022-28404-7 Pubmed: 35136046 ]
- Ampa glutamate receptor 2, flip isoform, q/r edited (Protein from Rattus norvegicus)
- Glua1 ampa glutamate receptor 1, flip isoform (Protein from Rattus norvegicus)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- Tarp-gamma 8 (Protein from Rattus norvegicus)
Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I)
Resolution: 8.25 Å
EM Method: Single-particle
Fitted PDBs: 5ide
Q-score: 0.187
Herguedas B, Garcia-Nafria J, Cais O, Fernandez-Leiro R, Krieger J, Ho H, Greger IH
Science (2016) 352 pp. aad3873-aad3873 [ DOI: doi:10.1126/science.aad3873 Pubmed: 26966189 ]
- Glutamate receptor 3 (99 kDa, Protein from Rattus norvegicus)
- Ampa glua2/3 heterotetramer (400 kDa, Complex from Rattus norvegicus)
- Glutamate receptor 2 (97 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model II)
Resolution: 10.31 Å
EM Method: Single-particle
Fitted PDBs: 5idf
Q-score: 0.114
Herguedas B, Garcia-Nafria J, Cais O, Fernandez-Leiro R, Krieger J, Ho H, Greger IH
Science (2016) 352 pp. aad3873-aad3873 [ DOI: doi:10.1126/science.aad3873 Pubmed: 26966189 ]
- Glutamate receptor 3 (99 kDa, Protein from Rattus norvegicus)
- Ampa glua2/3 heterotetramer (400 kDa, Complex from Rattus norvegicus)
- Glutamate receptor 2 (97 kDa, Protein from Rattus norvegicus)