Structure of the human neutral amino acid transporter ASCT2 in complex with nanobody 469
Resolution: 2.31 Å
EM Method: Single-particle
Fitted PDBs: 8oud
Q-score: 0.666
Khare S, Villalba MI, Canul-Tec JC, Cajiao AB, Kumar A, Backovic M, Rey FA, Pardon E, Steyaert J, Perez C, Reyes N
Nat Struct Mol Biol (2024) [ Pubmed: 38671230 DOI: doi:10.1038/s41594-024-01295-6 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Alanine serine cysteine transporter 2 (Complex from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Neutral amino acid transporter b(0) (56 kDa, Protein from Homo sapiens)
- Complex of human asct2 with nanobody 69 (200 kDa, Complex)
- Water (18 Da, Ligand)
- Alanine (89 Da, Ligand)
- Nanobody 469 (13 kDa, Protein from Lama glama)
- Nanobody 69 (Complex from Lama glama)
Complex of human ASCT2 with Syncytin-1
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8ouh
Q-score: 0.553
Khare S, Villalba MI, Canul-Tec JC, Cajiao AB, Kumar A, Backovic M, Rey FA, Pardon E, Steyaert J, Perez C, Reyes N
Nat Struct Mol Biol (2024) [ Pubmed: 38671230 DOI: doi:10.1038/s41594-024-01295-6 ]
- Complex of asct2 with synctin-1 (180 MDa, Complex)
- Alanine serine cysteine transporter 2 (Complex from Homo sapiens)
- Syncytin-1 (Complex from Homo sapiens)
- Neutral amino acid transporter b(0) (58 kDa, Protein from Homo sapiens)
- Alanine (89 Da, Ligand)
- Syncytin-1 (49 kDa, Protein from Homo sapiens)
Complex of ASCT2 with Suppressyn
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8oui
Q-score: 0.435
Khare S, Villalba MI, Canul-Tec JC, Cajiao AB, Kumar A, Backovic M, Rey FA, Pardon E, Steyaert J, Perez C, Reyes N
Nat Struct Mol Biol (2024) [ Pubmed: 38671230 DOI: doi:10.1038/s41594-024-01295-6 ]
- Suppressyn (18 kDa, Protein from Homo sapiens)
- Alanine (89 Da, Ligand)
- Complex of alanine serine cysteine transporter 2 with suppressyn (Complex from Homo sapiens)
- Neutral amino acid transporter b(0) (57 kDa, Protein from Homo sapiens)
Heterotrimeric Complex of Human ASCT2 with Syncytin-1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ouj
Q-score: 0.339
Khare S, Villalba MI, Canul-Tec JC, Cajiao AB, Kumar A, Backovic M, Rey FA, Pardon E, Steyaert J, Perez C, Reyes N
Nat Struct Mol Biol (2024) [ Pubmed: 38671230 DOI: doi:10.1038/s41594-024-01295-6 ]
- Alanine serine cysteine transporter 2 (Complex from Homo sapiens)
- Syncytin-1 (Complex from Homo sapiens)
- Neutral amino acid transporter b(0) (58 kDa, Protein from Homo sapiens)
- Alanine (89 Da, Ligand)
- Complex asct2 with syncytin-1 (180 MDa, Complex)
- Syncytin-1 (49 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike in complex with the neutralizing antibody Cv2.1169
Planchais C, Fernandez I, Bruel T, de Melo GD, Prot M, Beretta M, Guardado-Calvo P, Dufloo J, Molinos-Albert LM, Backovic M, Chiaravalli J, Giraud E, Vesin B, Conquet L, Grzelak L, Planas D, Staropoli I, Guivel-Benhassine F, Hieu T, Boulle M, Cervantes-Gonzalez M, Ungeheuer MN, Charneau P, van der Werf S, Agou F, Dimitrov JD, Simon-Loriere E, Bourhy H, Montagutelli X, Rey FA, Schwartz O, Mouquet H
J Exp Med (2022) 219 [ DOI: doi:10.1084/jem.20220638 Pubmed: 35704748 ]
Pre-fusion conformation of glycoprotein B of Herpes simplex virus 1
Resolution: 9.1 Å
EM Method: Subtomogram averaging
Fitted PDBs: 6z9m
Q-score: 0.155
Vollmer B, Prazak V, Vasishtan D, Jefferys EE, Hernandez-Duran A, Vallbracht M, Klupp BG, Mettenleiter TC, Backovic M, Rey FA, Topf M, Grunewald K
Sci Adv (2020) 6 [ Pubmed: 32978151 DOI: doi:10.1126/sciadv.abc1726 ]
- Human alphaherpesvirus 1 (300 kDa, Virus from Human alphaherpesvirus 1)
- Envelope glycoprotein b (100 kDa, Protein from Human herpesvirus 1)
Resolution: 35.0 Å
EM Method: Single-particle
Fitted PDBs: 6avq
Q-score: 0.045
Borst AJ, James ZM, Zagotta WN, Ginsberg M, Rey FA, DiMaio F, Backovic M, Veesler D
Structure (2017) 25 pp. 1732-1739.e5 [ Pubmed: 29033288 DOI: doi:10.1016/j.str.2017.09.007 ]
- Lm609 fab light chain (23 kDa, Protein from Mus musculus)
- Integrin alpha-v (105 kDa, Protein from Homo sapiens)
- Lm609 fab heavy chain (27 kDa, Protein from Mus musculus)
- Integrin beta-3 (76 kDa, Protein from Homo sapiens)
- Quaternary complex of human alpha-v beta-3 integrin with the fab lm609 (230 kDa, Complex from Homo sapiens)
Resolution: 35.0 Å
EM Method: Single-particle
Fitted PDBs: 6avr
Q-score: 0.046
Borst AJ, James ZM, Zagotta WN, Ginsberg M, Rey FA, DiMaio F, Backovic M, Veesler D
Structure (2017) 25 pp. 1732-1739.e5 [ Pubmed: 29033288 DOI: doi:10.1016/j.str.2017.09.007 ]
- Fab lm609 light chain (23 kDa, Protein from Mus musculus)
- Fab lm609 heavy chain (27 kDa, Protein from Mus musculus)
- Integrin alpha-v (105 kDa, Protein from Homo sapiens)
- Integrin beta-3 (76 kDa, Protein from Homo sapiens)
- Quaternary complex of human alpha-v beta-3 integrin with the fab lm609 (230 kDa, Complex from Homo sapiens)
Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609
Resolution: 35.0 Å
EM Method: Single-particle
Fitted PDBs: 6avu
Q-score: 0.051
Borst AJ, James ZM, Zagotta WN, Ginsberg M, Rey FA, DiMaio F, Backovic M, Veesler D
Structure (2017) 25 pp. 1732-1739.e5 [ Pubmed: 29033288 DOI: doi:10.1016/j.str.2017.09.007 ]
- Fab lm609 light chain (23 kDa, Protein from Mus musculus)
- Fab lm609 heavy chain (27 kDa, Protein from Mus musculus)
- Integrin alpha-v (105 kDa, Protein from Homo sapiens)
- Integrin beta-3 (76 kDa, Protein from Homo sapiens)
- Quaternary complex of human alpha-v beta-3 integrin with the fab lm609 (230 kDa, Complex from Homo sapiens)