EMD-78337
Cryo-EM structure of human beta-cardiac myosin carrying the E525K mutation in the Interacting-Heads Motif state
EMD-78337
Single-particle3.0 Å
Deposition: 29/07/2026Map released: 04/11/2026
Last modified: 04/11/2026
Sample Organism:
Mus musculus,
Homo sapiens,
Aequorea victoria
Sample: Human beta-cardiac myosin carrying the E525K mutation in the interacting-heads motif state
Fitted models: 37oa
Deposition Authors: Somavarapu AK
,
Gautam R ,
Craig R ,
Padron R ,
Craig R ,
Padron R
Sample: Human beta-cardiac myosin carrying the E525K mutation in the interacting-heads motif state
Fitted models: 37oa
Deposition Authors: Somavarapu AK
,
Gautam R ,
Craig R ,
Padron R ,
Craig R ,
Padron R
The dilated cardiomyopathy E525K mutation stabilizes the cardiac myosin interacting-heads motif while activating the isolated motor domain.
Gautam R ,
Somavarapu AK ,
Robeson KZ ,
Childers MC ,
Regnier M ,
Ge J ,
Yengo CM ,
Craig R ,
Padron R
(2026) bioRxiv
,
Somavarapu AK ,
Robeson KZ ,
Childers MC ,
Regnier M ,
Ge J ,
Yengo CM ,
Craig R ,
Padron R
(2026) bioRxiv
Grant Support:
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL164560 (United States)
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS): AR081941 (United States)
- American Heart Association: 26CDA1600784 (United States)