EMD-75835

Single-particle
3.0 Å
EMD-75835
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Deposition: 04/03/2026
Map released: 17/06/2026
Last modified: 17/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75835
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 11mh summary report (pdf.gz) Map and 11mh FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM Structure of Human C3 Pro-Convertase bound to the Compstatin Analog Cp60, TED Conformation 2

EMD-75835

Single-particle
3.0 Å
EMD-75835
3D View Gallery
Deposition: 04/03/2026
Map released: 17/06/2026
Last modified: 17/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Cryo-EM Structure of Human C3 Pro-Convertase bound to the Compstatin Analog Cp60, TED Conformation 2
Fitted models: 11mh

Deposition Authors: Herbine K, Lambris J
New Analogs of the Compstatin Family of Clinical Complement Inhibitors with Low Picomolar Target Affinity.
Vogt SA, Lander AJ, Herbine K, Umnyakova E, Felsch J, Aschwanden R, Hughes SE, Schwardt O, Lill MA, Smiesko M, Lambris JD, Lamers C, Ricklin D
(2026) J Med Chem , 69 , 11592 - 11609
PUBMED: 42063338
DOI: doi:10.1021/acs.jmedchem.6c00832
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: