EMD-75302
Cryo-EM structure of human IL-10RA and IL-10RB in complex with tandem VHHs E07-A05
EMD-75302
Single-particle3.14 Å
Deposition: 28/01/2026Map released: 21/10/2026
Last modified: 28/10/2026
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Complex of human IL-10RA, IL-10RB with tandem VHHs E07-A05 and anti-VHH Fab
Fitted models: 10ne
Deposition Authors: Xu H
Sample: Complex of human IL-10RA, IL-10RB with tandem VHHs E07-A05 and anti-VHH Fab
Fitted models: 10ne
Deposition Authors: Xu H
Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism.
Canaria DA ,
Nguyen TTT ,
Huang H ,
Xu H ,
Yue L ,
Fu Y,
Truong H,
Patel K ,
Xing W,
Ravichandar JD,
Xing C ,
Martin AL,
Delidakis G ,
Wong S,
Pae A ,
Yu Y,
Macdonald R ,
Huang Z,
Main MC,
Rodriguez A,
Lin X,
Mouchess ML ,
Hung M,
McGlinchey EM ,
Chen L,
Schirle Oakdale N,
Carr B,
Koleske ML,
Lee CV ,
Chen C ,
Yi T
(2026) Nature
,
Nguyen TTT ,
Huang H ,
Xu H ,
Yue L ,
Fu Y,
Truong H,
Patel K ,
Xing W,
Ravichandar JD,
Xing C ,
Martin AL,
Delidakis G ,
Wong S,
Pae A ,
Yu Y,
Macdonald R ,
Huang Z,
Main MC,
Rodriguez A,
Lin X,
Mouchess ML ,
Hung M,
McGlinchey EM ,
Chen L,
Schirle Oakdale N,
Carr B,
Koleske ML,
Lee CV ,
Chen C ,
Yi T
(2026) Nature
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