EMD-75301

Single-particle
2.4 Å
EMD-75301 Deposition: 28/01/2026
Map released: 21/10/2026
Last modified: 28/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75301

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-10nd summary report (pdf.gz) Map-10nd FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human IL-10RA in complex with VHH E07

EMD-75301

Single-particle
2.4 Å
EMD-75301 Deposition: 28/01/2026
Map released: 21/10/2026
Last modified: 28/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: Complex of human IL-10RA with VHH E07 and anti-VHH Fab
Fitted models: 10nd

Deposition Authors: Xu H
Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism.
PUBMED: 42875499
DOI: doi:10.1038/s41586-026-11176-1
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: