EMD-75038

Single-particle
2.9 Å
EMD-75038
3D View Gallery
Deposition: 09/01/2026
Map released: 22/04/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75038

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-10ay summary report (pdf.gz) Map-10ay FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of CRBN-DDB1 in complex with HBS1L and TNG961

EMD-75038

Single-particle
2.9 Å
EMD-75038
3D View Gallery
Deposition: 09/01/2026
Map released: 22/04/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of HBS1L, cereblon, and DDB1 with TNG961
Fitted models: 10ay

Deposition Authors: Whittington DA
TNG961 is a selective oral HBS1L molecular glue degrader for the treatment of FOCAD-deleted cancers.
Nicholson HE, Whittington DA, Bruzzese FJ, Lazarides K, Martires LCM, Tonini MR, Jenkins HN, Zhang M, Shahagadkar P, Pratt CB, Briggs KJ, McCarren P, Tsai A, Bandi M, Min C, Huang A, Zhang H, Meier SR, Shen B, Yu Y, Liang C, Liu Y, Teng T, Zhang J, Crystal A, Mallender WD, Wu XE, Maxwell JP, Andersen JN
(2026) Cancer Discov
PUBMED: 42001523
DOI: doi:10.1158/2159-8290.CD-26-0040
ISSN: 2159-8290
Grant Support: