EMD-73873
Cryo-EM structure of Secreted extracellular protein A (SepA) from Shigella flexneri complexed with the fragment antigen binding domain of monoclonal antibody 40
EMD-73873
Single-particle1.99 Å
Deposition: 16/11/2025Map released: 03/06/2026
Last modified: 01/07/2026
Sample Organism:
Shigella flexneri 2a str. 2457T,
Homo sapiens
Sample: Binary complex of the recombinant SepA passenger domain with Fab 40
Fitted models: 9z7a
Deposition Authors: Buckley DP
,
Berndsen ZT
Sample: Binary complex of the recombinant SepA passenger domain with Fab 40
Fitted models: 9z7a
Deposition Authors: Buckley DP
,
Berndsen ZT
Human enterotoxigenic Escherichia coli (ETEC) infections elicit antibodies that broadly neutralize mucinases of pathogenic Escherichia coli and Shigella.
Buckley DP ,
Akhtar M,
Thapa M ,
Schmitz A,
Turner J,
Vickers TJ,
Khatoon N,
Kaisar MH ,
Coggin JA ,
Ganguli D,
Sheikh A ,
Laird RM,
Poly F,
Porter CK,
Ruiz-Perez F,
Miller MJ,
Chowdhury F,
Bhuiyan TR ,
Qadri F,
Trillo-Muyo S ,
Dolan B ,
van der Post S ,
Ellebedy A,
Berndsen ZT,
Fleckenstein JM
(2026) PNAS , 123 , e2614012123 - e2614012123
,
Akhtar M,
Thapa M ,
Schmitz A,
Turner J,
Vickers TJ,
Khatoon N,
Kaisar MH ,
Coggin JA ,
Ganguli D,
Sheikh A ,
Laird RM,
Poly F,
Porter CK,
Ruiz-Perez F,
Miller MJ,
Chowdhury F,
Bhuiyan TR ,
Qadri F,
Trillo-Muyo S ,
Dolan B ,
van der Post S ,
Ellebedy A,
Berndsen ZT,
Fleckenstein JM
(2026) PNAS , 123 , e2614012123 - e2614012123
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI089894 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI126887 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): T32AI007172 (United States)
- Department of Veterans Affairs (VA, United States): 5I01BX001469-05 (United States)