EMD-73787
SARS-CoV-2 S2 trimer stabilized in the early fusion intermediate conformation by circular permutation and clamping by gp41 (E-FICs-v1)
EMD-73787
Single-particle3.3 Å
Deposition: 07/11/2025Map released: 13/05/2026
Last modified: 03/06/2026
Sample Organism:
Homo sapiens,
Severe acute respiratory syndrome coronavirus 2
Sample: SARS-CoV-2 S2 trimer stabilized in the early fusion intermediate conformation by circular permutation and clamping by gp41 (E-FICs-v1)
Fitted models: 9z3k
Deposition Authors: McCallum M
,
Seattle Structural Genomics Center for Infectious Disease (SSGCID),
Veesler D
Sample: SARS-CoV-2 S2 trimer stabilized in the early fusion intermediate conformation by circular permutation and clamping by gp41 (E-FICs-v1)
Fitted models: 9z3k
Deposition Authors: McCallum M
,
Seattle Structural Genomics Center for Infectious Disease (SSGCID),
Veesler D
TMPRSS2-mediated coronavirus spike activation and inhibition.
McCallum M ,
Case JB ,
Brown JT,
Park YJ ,
Lee J,
Sutherland E ,
Aggarwal A,
Gibson C,
Lempp FA ,
Stewart C ,
Tortorici MA ,
Sanapala S,
Low JS,
Asarnow D ,
Bohan D ,
Dellota Jr E,
Merz B,
Chawla B,
Kar S,
Lanzavecchia A ,
Sallusto F,
Riley NM ,
Turville S,
Purcell L,
Diamond MS ,
Veesler D
(2026) Nat Struct Mol Biol , 33 , 810 - 823
,
Case JB ,
Brown JT,
Park YJ ,
Lee J,
Sutherland E ,
Aggarwal A,
Gibson C,
Lempp FA ,
Stewart C ,
Tortorici MA ,
Sanapala S,
Low JS,
Asarnow D ,
Bohan D ,
Dellota Jr E,
Merz B,
Chawla B,
Kar S,
Lanzavecchia A ,
Sallusto F,
Riley NM ,
Turville S,
Purcell L,
Diamond MS ,
Veesler D
(2026) Nat Struct Mol Biol , 33 , 810 - 823
Grant Support:
- Howard Hughes Medical Institute (HHMI): (United States)