EMD-73645

Single-particle
2.8 Å
EMD-73645
3D View Gallery
Deposition: 29/10/2025
Map released: 15/07/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73645
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9yyh summary report (pdf.gz) Map and 9yyh FULL report (pdf.gz)
EMICSS annotations (xml)

AI-generated RNA-guided nuclease R-loop formed state

EMD-73645

Single-particle
2.8 Å
EMD-73645
3D View Gallery
Deposition: 29/10/2025
Map released: 15/07/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: synthetic construct, Deinococcus radiodurans
Sample: AI-designed RNA-guided nuclease R-loop formed state
Fitted models: 9yyh

Deposition Authors: Skopintsev P, Esain-Garcia I, Doudna J
Structure and evolution-guided design of minimal RNA-guided nucleases
Skopintsev P, Esain-Garcia I, DeTurk EC, Yoon PH, Zhou Z, Weiss T, Kamalu M, Chamraj A, Loi KJ, Langeberg CJ, Boger RS, Nisonoff H, Karp HM, Chen LX, Shi H, Vohra K, Banfield JF, Cate JHD, Jacobsen SE, Doudna JA
(2026) Science , 393 , 313 - 318
DOI: doi:10.1126/science.aed6123
ISSN: 1095-9203
ASTM: SCIEAS