EMD-73509

Single-particle
2.7 Å
EMD-73509
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Deposition: 23/10/2025
Map released: 15/04/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73509
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9yuy summary report (pdf.gz) Map and 9yuy FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of the Plasmodium falciparum 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor.

EMD-73509

Single-particle
2.7 Å
EMD-73509
3D View Gallery
Deposition: 23/10/2025
Map released: 15/04/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Plasmodium falciparum 3D7
Sample: Plasmodium falciparum 20S proteasome
Fitted models: 9yuy

Deposition Authors: Yan NL, Gu X , Fajtova P, Tse E, Melo A, Southworth DR , O'Donoghue A, Sello JK , Gestwicki JE
An Optimized Route to the Syringolin Natural Products Enables Combinatorial Synthesis of Selective, Bioactive Inhibitors of the Plasmodium falciparum 20S Proteasome.
Gu X , Fajtova P, Yan NL, Saxena A, Fei F , Zhu J , Tse E, Melo A, Yoo E , Buchwald NH, Southworth DR , Bogyo M , Derisi JL, Gestwicki JE , O'Donoghue AJ, Sello JK
(2026) J Med Chem , 69 , 8897 - 8914
PUBMED: 41921688
DOI: doi:10.1021/acs.jmedchem.5c03223
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: