EMD-73374

Single-particle
3.2 Å
EMD-73374
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Deposition: 17/10/2025
Map released: 24/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73374
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9yrq summary report (pdf.gz) Map and 9yrq FULL report (pdf.gz)
EMICSS annotations (xml)

Factor XIa in complex with Fab fragment of REGN9933-A2

EMD-73374

Single-particle
3.2 Å
EMD-73374
3D View Gallery
Deposition: 17/10/2025
Map released: 24/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Factor XIa in complex with REGN9933-A2 Fab
Fitted models: 9yrq

Deposition Authors: Saotome K, Franklin MC
Anticoagulation with mechanistically distinct FXI/FXIa antibodies amrecibart (REGN9933A2) and cenvacibart (REGN7508Cat).
Chalothorn D, Kithcart AP, Marin E, Somersan-Karakaya S, Lai K, Cauwberghs F, Ackroyd JPR, Mohammadi K, Shrestha A, Ehrlich GK, Rafique A, Chatterjee I, Saotome K, Franklin MC, Murphy AJ, Olson WC, Olenchock BA, Herman GA, Gutstein DE, Sirulnik A, Yancopoulos GD, Morton LG
(2026) Blood
PUBMED: 42275249
DOI: doi:10.1182/blood.2025032276
ISSN: 1528-0020
Grant Support: