EMD-73364

Single-particle
3.06 Å
EMD-73364
3D View Gallery
Deposition: 16/10/2025
Map released: 24/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73364

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9yrb summary report (pdf.gz) Map-9yrb FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Factor XIa in complex with Fab fragment of REGN7508-Cat

EMD-73364

Single-particle
3.06 Å
EMD-73364
3D View Gallery
Deposition: 16/10/2025
Map released: 24/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Factor XIa in complex with REGN7508 Fab
Fitted models: 9yrb

Deposition Authors: Saotome K, Franklin MC
Anticoagulation with mechanistically distinct FXI/FXIa antibodies amrecibart (REGN9933A2) and cenvacibart (REGN7508Cat).
Chalothorn D, Kithcart AP, Marin E, Somersan-Karakaya S, Lai K, Cauwberghs F, Ackroyd JPR, Mohammadi K, Shrestha A, Ehrlich GK, Rafique A, Chatterjee I, Saotome K, Franklin MC, Murphy AJ, Olson WC, Olenchock BA, Herman GA, Gutstein DE, Sirulnik A, Yancopoulos GD, Morton LG
(2026) Blood
PUBMED: 42275249
DOI: doi:10.1182/blood.2025032276
ISSN: 1528-0020
Grant Support: