EMD-73041

Single-particle
2.36 Å
EMD-73041
3D View Gallery
Deposition: 06/10/2025
Map released: 18/03/2026
Last modified: 18/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73041

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9yk0 summary report (pdf.gz) Map-9yk0 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

cryoEM structure of Aspergillus fumigatus acetolactate synthase (ALS) in complex with a novel inhibitor

EMD-73041

Single-particle
2.36 Å
EMD-73041
3D View Gallery
Deposition: 06/10/2025
Map released: 18/03/2026
Last modified: 18/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Aspergillus fumigatus
Sample: Aspergillus fumigatus Acetolactate synthase
Fitted models: 9yk0

Deposition Authors: Hu Y
An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining.
Perlatti B , Vellanki S, Zhang Y, Chiang YM , Hu Y, Yuan M, Dunbar K, Fine A, Grau MF, Li S, O'Donnell T, Shenoy R, Li H, Shi H, Xu X, Chen Z, Arvedson T, Tang Y, Cramer RA, Cee V, Harvey CJB
(2026) ACS Cent Sci , 12 , 197 - 207
PUBMED: 41768770
DOI: doi:10.1021/acscentsci.5c02019
ISSN: 2374-7951
Grant Support: