EMD-72964

Single-particle
2.69 Å
EMD-72964
3D View Gallery
Deposition: 30/09/2025
Map released: 04/02/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72964

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9yha summary report (pdf.gz) Map-9yha FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of IDH1 R132H

EMD-72964

Single-particle
2.69 Å
EMD-72964
3D View Gallery
Deposition: 30/09/2025
Map released: 04/02/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human isocitrate dehydrogenase 1 R132H mutant
Fitted models: 9yha

Deposition Authors: Hu L , Seo H-S, Dhe-Paganon S , Berezuk AM, Tuttle KS, Zhu X, Subramaniam S, Wu X
Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells.
Hu L , Lin J, Sun L , Berezuk AM, Tuttle KS, Zhu X, Seo HS , Dhe-Paganon S , Li P, Sun Y, Ni L, Zhang J, Tan D, Wakimoto H , Cahill DP, Bai X , Luo X , Asara JM , Subramaniam S, Shan Y , Wu X
(2026) Nat Chem Biol , 22 , 1087 - 1098
PUBMED: 41530531
DOI: doi:10.1038/s41589-025-02131-8
ISSN: 1552-4469
Grant Support: