EMD-72762

Single-particle
4.02 Å
EMD-72762
3D View Gallery
Deposition: 18/09/2025
Map released: 19/08/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72762

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9yc8 summary report (pdf.gz) Map-9yc8 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Leucine Rich Repeat Kinase 2 activate state (Apo ROC state 1)

EMD-72762

Single-particle
4.02 Å
EMD-72762
3D View Gallery
Deposition: 18/09/2025
Map released: 19/08/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Leucine Rich Repeat Kinase 2 asymmetric dimer
Fitted models: 9yc8

Deposition Authors: Villagran Suarez A, Bodrug T, Leschziner A
The structural basis for LRRK2's activation and autoinhibition.
Villagran Suarez A, Hatch KS, Bodrug T, Gai W, Surridge KJ, Moussikhina E, Nguyen KHV, Sanz-Murillo M, Callahan R, Xiong E, Ramos D, Zhu L, Dederer V, Mathea S, Iwasa J, Knapp S, Shokat KM, Reck-Peterson SL, Leschziner AE
(2026) Cell
PUBMED: 42575089
DOI: doi:10.1016/j.cell.2026.07.027
ISSN: 1097-4172
Grant Support: